Erin Zwak/Brodsky Lab & Penn Vet Imaging Core - Murine macrophages infected with Yersinia pseudo tuberculosis. Blue indicates the cell, red is a mitochondrial stain, green is a stain for Yersinia secreted effector proteins.
Claudio Giraudo - Polarization of lytic granules to the immunological synapse during the cytolytic process of human CD8 lymphocytes against cancer cells.
Gretchen Harms, Hunter lab - Stylized images of CD8+ T cells looking at differential localization of the transcription factor T-bet in mouse cells after infection with the parasite Toxoplasma gondii, using the Amnis ImageStream. In the cell in the first and third box, T-bet (red) does not co-localize with DAPI (blue), indicating that it is cytoplasmic, whereas in the cell in the second and fourth box, T-bet does co-localize with DAPI, indicating that it is nuclear. David Christian assisted in obtaining these images.
The Infectious Diseases Program of the IFI focuses on defining the nature and underlying mechanisms of protective and non-protective immune responses to microorganisms including bacteria, viruses, and parasites. The program supports both basic immunopathogenesis research in model systems as well as translational research in humans. Focus areas include, but are not limited to mechanisms of immunopathogenesis of: lentiviruses, acute and chronic viral, bacterial and parasitic infections in model systems and humans. We seek to encourage collaborations specifically between basic and translational infectious disease researchers in order to gain insight from model systems towards a greater understanding of human immune responses to infectious diseases.