Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.
3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.
Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.
The Infectious Diseases Program of the IFI focuses on defining the nature and underlying mechanisms of protective and non-protective immune responses to microorganisms including bacteria, viruses, and parasites. The program supports both basic immunopathogenesis research in model systems as well as translational research in humans. Focus areas include, but are not limited to mechanisms of immunopathogenesis of: lentiviruses, acute and chronic viral, bacterial and parasitic infections in model systems and humans. We seek to encourage collaborations specifically between basic and translational infectious disease researchers in order to gain insight from model systems towards a greater understanding of human immune responses to infectious diseases.