Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.
3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.
Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.
While inflammation is an essential and important part of the physiological and immunological response to infection and tissue injury, prolonged or inappropriate inflammation can result in pathological situations including allergy and asthma, sepsis, respiratory distress, cardiovascular disease, autoimmunity and some forms of cancer. IFI researchers are investigating how the balance between the healthy and important aspects of inflammation and pathological consequences of dysregulated inflammation is achieved or becomes dysregulated in multiple infectious, inflammatory and metabolic disease states.