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    Erin Zwak/Brodsky Lab & Penn Vet Imaging Core - Murine macrophages infected with Yersinia pseudo tuberculosis. Blue indicates the cell, red is a mitochondrial stain, green is a stain for Yersinia secreted effector proteins.

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    Claudio Giraudo - Polarization of lytic granules to the immunological synapse during the cytolytic process of human CD8 lymphocytes against cancer cells.

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    Gretchen Harms, Hunter lab - Stylized images of CD8+ T cells looking at differential localization of the transcription factor T-bet in mouse cells after infection with the parasite Toxoplasma gondii, using the Amnis ImageStream. In the cell in the first and third box, T-bet (red) does not co-localize with DAPI (blue), indicating that it is cytoplasmic, whereas in the cell in the second and fourth box, T-bet does co-localize with DAPI, indicating that it is nuclear. David Christian assisted in obtaining these images.

Inflammation

While inflammation is an essential and important part of the physiological and immunological response to infection and tissue injury, prolonged or inappropriate inflammation can result in pathological situations including allergy and asthma, sepsis, respiratory distress, cardiovascular disease, autoimmunity and some forms of cancer. IFI researchers are investigating how the balance between the healthy and important aspects of inflammation and pathological consequences of dysregulated inflammation is achieved or becomes dysregulated in multiple infectious, inflammatory and metabolic disease states.