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    Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.

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    3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.

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    Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.

Transplantation

The focus of the Transplantation Immunology Program is alloimmunity associated with human solid organ and bone marrow transplantation therapies. Its members cover a broad range of immunological disciplines, including tolerance, inflammation, and innate, adaptive, and molecular mechanisms of alloimmunity. Specific areas of expertise include immunosuppression, ischemia-reperfusion injury, humoral and cellular mechanisms of acute rejection and chronic allograft dysfunction, cellular and molecular mechanisms of tolerance, and the impact of resident microbial populations on transplant immunity. In addition to models of transplantation, Transplantation Immunology Program members are also engaged in translational research involving human populations. As such, there is a major emphasis on team science that aligns clinicians and researchers to promote sharing of patient samples for relevant research, which in turn is used for efficient cycling of lab and human science, ideally positioning this group for strategic funding initiatives.