Immunology Graduate Group

Avinash Bhandoola, Ph.D.
Assistant Professor, Pathology and Laboratory Medicine

Address: 264/266 John Morgan Building, 37th and Hamilton Walk
Office Phone: 215-573-0274
Lab Phone: 215-573-3831
Fax: 215-898-2401
Email: bhandooa@mail.med.upenn.edu

Education:
Ph.D., University of Pennsylvania
M.B., B.S., Grant Medical College, Bombay, India

Research Interests

We're chiefly interested in the steps linking hematopoietic stem cells to the earliest T lineage progenitors in the thymus. We're also interested in models of T cell aging and cancer, using the information we gain from studying normal development.

Research Summary

Current projects in the laboratory include:
-Early lymphoid specification in the bone marrow.
-Signals that allow hematopoietic progenitors to leave the bone marrow, gain access to the circulation and potentially the thymus.
-Early intrathymic differentiation of hematopoietic progenitors that colonize thymus from blood.
-Models of thymic aging.

Recent Publications

1. Miller, J. P., D. Izon, W. DeMuth, R. Gerstein, A. Bhandoola, and D. Allman. 2002. The Earliest Step in B Lineage Differentiation from Common Lymphoid Progenitors Is Critically Dependent upon Interleukin 7. J. Exp. Med. 196:705.
2. Bhandoola, A., X. Tai, M. Eckhaus, H. Auchincloss, K. Mason, S. A. Rubin, K. M. Carbone, Z. Grossman, A. S. Rosenberg, and A. Singer. 2002. Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model. Immunity 17:425.
3. Bhandoola, A., R. Bosselut, Q. Yu, M. L. Cowan, L. Feigenbaum, P. E. Love, and A. Singer. 2002. CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain. Eur. J. Immunol. 32:1811.
4. Yu, Q., B. Erman, A. Bhandoola, S. O. Sharrow, and A. Singer. 2003. In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J. Exp. Med. 197:475.
5. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4:168.
6. Bhandoola, A., A. S. Rosenberg, and A. Singer. 2003. CD4(+) T-cell responses to self-peptide-MHC. Trends Immunol 24:171.

 

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