Current students

Michael Abt
B.S. Biology, Loyola College of Maryland (2006)

Matriculated: 2006
Thesis Advisor: David Artis
Research Interests: Investigating the role of the intestinal microbiota in shaping the immune response to infection

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Jill Angelosanto
B.S. Biochemistry, Smith College (2005)
jangelos@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: John Wherry
Research Interests: Development of CD8+ T cell memory and exhausiton,ÊTranscriptional regulation of CD8+ T cell memory
Publications:
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med. 2010 Oct;16(10):1147-51.

Angelosanto JM and Wherry EJ. Transcription factor regulation of CD8+ T-cell memory and exhausion. Immunological Reviews. 2010 Jul;236:167-75

Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 2009 Aug 21;31(2):309-20.

Haining WN, Davies J, Kanzler H, Drury L, Brenn T, Evans J, Angelosanto J, Rivoli S, Russell K, George S, Sims P, Neuberg D, Li X, Kutok J, Morgan J, Wen P, Demetri G, Coffman RL, Nadler LM. CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res 2008 Sep 1;14(17):5626-34.

Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol 2008 Aug 1;181(3):1859-68.

Haining WN, Angelosanto J, Brosnahan K, Ross K, Hahn C, Russell K, Drury L, Norton S, Nadler L, Stegmaier K. High-throughput gene expression profiling of memory differentiation in primary human T cells. BMC Immunol 2008 Aug 1;9:44.

Day RM, Agyeman AS, Segel MJ, Chevere RD, Angelosanto JM, Suzuki YJ, Fanburg BL. Serotonin induces pulmonary artery smooth muscle cell migration. Biochem Pharmacol 2006 Jan 12;71(3):386-97.

Mike Askenase

Mike Askenase
B.S. Biology, Tufts University (2006)
askenase@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: Phil Scott
Research Interests: Host-Pathogen interactions, Mucosal immunity
Publication:
Cabaton NJ, Wadia PR, Rubin BS, Zalko D, Schaeberle CM, Askenase MH, Gadbois JL, Tharp AP, Whitt GS, Sonnenschein C, Soto AM. Perinatal Exposure to Environmentally Relevant Levels of Bisphenol-A Decreases Fertility and Fecundity in CD-1 Mice. Environ Health Perspect. 2010 Nov 19.

Will Bailis

Will Bailis
B.A. Biochemistry, Vassar College (2008)
bailis@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Warren Pear
Research interests: Infectious immunity and hematopoiesis
Publications:
Keeshan K,* Bailis W,* Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 2010 Dec 2;116(23):4948-57.

Okeoma CM, Low A, Bailis W, Fan HY, Peterlin BM, Ross SR. Aug 30.Induction of APOBEC3 in vivo causes increased restriction of
retrovirus infection. J Virol. 2009 Apr;83(8):3486-95.

Burt Barnett

Burton Barnett
B.S. Molecular Biology, University of California, San Diego (2008)
bbarn@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: Steve Reiner
Research Interests: Asymmetric cell division in the immune system
Publication:
Bcl6 and Blimp1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Science. 2009 Aug 21:325(5943):1006-10. Epub 2009 Jul 16.

Lisa Barnett

Lisa Barnett
B.S. Biochemistry and Cell Biology, University of California, San Diego (2009)
lbarn@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: Terri Laufer
Research Interests: T cell differentiation and activation, antigen presentation

Weston Beck

Weston Beck
B.S. Molecular Biology, Brigham Young University (2008)
beckw@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: Paula Oliver

Emily Chen
B.S. Biology, Haverford College (2005)
emilyjc@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: Janis Burkhardt
Research Interests: Cell polarity, T cell migration
Publications:
Cannon JL, Mody PD, Blaine KM, Chen EJ, Nelson AD, Sayles LJ, Moore TV, Clay BS, Dulin NO, Shilling RA, Burkhardt JK, Sperling AI. CD43 interaction with ERM proteins regulates T cell trafficking and CD43 phosphorylation1. Mol Biol Cell. 2011 Feb 2.

Menasche G, Kliche S, Chen EJ, Stradal TE, Schraven B, Koretzky G.RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol. 2007 Jun;27(11):4070-81. Epub 2007 Apr 2

Irene Chernova

Irene Chernova
B.A. Molecular Biology, University of Pennsylvania (2007)
chernova@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: Dave Allman
Research Interests: Plasma cells, persistent humoral immunity
Publications:
Chernova I, Lai JP, Li H, Schwartz L, Tuluc F, Korchak HM, Douglas SD, Kilpatrick LE. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). J Leukoc Biol. 2009 Jan;85(1):154-64.

Kobayashi N, Karisola P, Pe–a-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 2007 Dec;27(6):927-40.

Appleman LJ, Chernova I, Li L, Boussiotis VA. CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation. Cell Cycle. 2006 Sep;5(18):2123-9.

Latchman Y et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology 2001; 2: 261-268.

Alan Copenhaver

Alan Copenhaver
B.S. Biology, Georgia State University (2009)

Matriculated: 2010
Current Rotation Advisor: Dave Allman
Research Interests: Neuroimmunology

Evann Corbo

Evann Corbo
B.S. Biology, The Richard Stockton College of New Jersey (2006)
corbo@mail.med.upenn.edu

Matriculated: 2006
Thesis Advisor: Jon Maltzman
Research Interests: Homeostasis of CD4+ memory T cells

Erika Crosby

Erika Crosby
B.S. Cell Biology and Biochemistry, Bucknell University (2009)
ejcrosby@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: Phil Scott
Research Interests: Infectious disease as it relates to T cell immunology
Publications:
Rakhra, K; Bachireddy, P; Zabuawala, T; Zeiser, Robert; Xu, L; Kopelman, A; Fan, A.C.; Yang, Q; Braunstein, L; Crosby, E; Ryeom, S; Felsher, D.W. CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation. Cancer Cell. 2010; 18(5): 485-498.

Gaylo, AE; Laux, KS; Batzel, EJ, Field, KA. Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors. Transplant Immunology. 2009; 20(3): 163-170.

Ellen De Obaldia

Ellen De Obaldia
B.A. Biology, Harvard University (2008)
mdeobald@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Avinash Bhandoola
Research interests: Tolerance and autoimmunity, hematopoiesis
Publications:
Melero-Martin JM, De Obaldia ME, Kang SY, Khan ZA, Yuan L, Oettgen P, Bischoff J. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circulation Research. 2008 Jul 18;103(2):194-202.

Weir MR, Neutel JM, Bhaumik A, De Obaldia ME, Lapuerta P. The efficacy and safety of initial use of irbesartan/hydrochlorothiazide fixed-dose combination in hypertensive patients with and without high cardiovascular risk. J Clinical Hypertension (Greenwich). 2007
Dec;9(12 Suppl 5):23-30.

Zhang Y, Rassa JC, De Obaldia ME, Albritton LM, Ross SR. Identification of the receptor binding domain of the mouse mammary
tumor virus envelope protein. J Virology. 2003 Oct;77(19):10468-78.

Dawson Gerhardt

Dawson Gerhardt
B.S. Biology, Georgia Insitute of Technology
dawsondmg@gmail.com

Matriculated: 2006
Thesis Advisor: Warren Pear
Research interests: Notch and development of the hematopoietic system

Carolyn Gray

Carolyn Gray
B.S. Biology, The College of New Jersey (2008)
cagray@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Michael May
Research interests: Mechanisms of non-canonical NF-kappaB activation
Publications:
Whitmarsh RJ, Gray CM, Gregg B, Murray PJ, May MJ, and Hunter CAH. In the absence of SOCS3, IL-6 becomes a prominent inhibitor of the ability of macrophages to control Toxoplasma gondii by inhibiting IL-12. Submitted.

Neely RJ, Brose MS, Gray CM, McCorkell KA, Leibowitz JM, Ma C, Rothstein JL, and May MJ. The Ret/PTC3 oncogene activates classical NF-kappaB by stabilizing NIK. Oncogene, 2011. 30(1): 87-96.

Scott Gordon

Scott Gordon
B.S. Biology, Haverford College (2006)

Matriculated: 2008
Thesis Advisor: Steven Reiner
Research interests: Immune memory, cell fate decisions
Selected Publications:
Intlekofer, A.M., A. Banerjee, N. Takemoto, S.M. Gordon, C.S. Dejong, H. Shin, C.A. Hunter, E.J. Wherry, T. Lindsten, S.L. Reiner. 2008. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science, 321(5887):408-11.

Danielle Haney
B.S. Biology, Xavier University of Louisiana (2006)
dhaney2@mail.med.upenn.edu

Matriculated: 2006
Thesis Advisor: Mike Betts
Research Interests: CD8 T cell Response to Chronic Viral Infections

Gretchen Harms

Gretchen Harms
B.A. Biology & Religion, Oberlin College (2006)
gharms@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: Carolina Lopez
Research Interests: Innate immunity, T cell memory
Selected Publications:
Cejas PJ, Walsh MC, Pearce EL, Han D, Harms GM, Artis D, Turka LA, Choi Y. TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood. 2010 Jun 10;115(23):4750-7.

Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature. 2009 Jul 2;460(7251):103-7

Julie Horowitz

Julie Horowitz
B.A. Chemistry, New College of Florida (2008)
jhoro@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor:Craig Bassing
Research Interests: Lymphocyte development and chromatin biology

Rohan Joshi

Rohan Joshi
B.A. Biochemistry, Columbia (2006)

Matriculated: 2009
Thesis Advisor: Gary Koretzky
Research Interests: Regulation of Lipids in T Cell Signaling
Selected Publications:
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA. Blood. 2010 May 20;115(20):4030-8. Epub 2010 Mar 30.

Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O'Shea MA, Mican J, Packard BZ, Komoriya A, Palmer S, Wiegand AP, Maldarelli F, Coffin JM, Mellors JW, Hallahan CW, Follman DA, Connors M. Immunity. 2008 Dec 19;29(6):1009-21. Epub 2008 Dec 8.

Jiyeon Kim
B.S., M.S. Molecular Biophysics and Biochemistry, Yale University (2007)

Matriculated: 2009
Thesis Advisor: Gary Koretzky
Research Interests: T cell signaling, T cell development and differentiation
Selected Publications:
Gordon S, Carty S, Kim JS, Zou T, Smith-Garvin JE, Alonzo ES, Haimm E, Sant’Angelo DB, Koretzky GA, Reiner SL, Jordan MS. Requirements for Eomesodermin and PLZF in the development of innate-like CD8+ T cells. J Immunol. 2011.

Smith-Garvin JE, Burns JC, Gohil M, Zou T, Kim JS, Maltzman JS, Wherry EJ, Koretzky GA, Jordan MS. T cell receptor signals direct the composition and function of the memory CD8+ T cell pool. Blood. 116 (25): 5548-59, 2010.

Park SG, Chung C, Kang H, Kim J, Jung G. Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter. J Biol Chem. 281 (42): 31770-7, 2006.

Theresa Leichner

Theresa Leichner
B.S. Biochemistry and Molecular Biology, Ursinus College (2008)

Matriculated: 2010
Current Rotation Advisor: Terri Laufer
Research Interests: T cell signaling, Tolerance and Autoimmunity

Susi Linderman

Susi Linderman
B.S. Biophysics, Brigham Young University (2010)
susannel@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: Scott Hensley
Research Interests: Innate immune responses to infectious disease (particularly to flu), cell homing, tolerance

Rebecca May

Rebecca May
B.S. Physiology, University of California, Los Angeles (2003)
slota@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Gary Koretzky
Research Interests: Cell signaling

Laurel Monticelli
M.S. Biology-Immunology, University of California, San Diego (2008)
B.S. Microbiology, University of California, San Diego (2007)
mlaurel@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: David Artis
Research Interests: Mucosal immunity
Publications:
Sonnenberg GF, Monticelli LA, Elloso MM, Fouser LA, Artis D. CD4(+) Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut. Immunity 34:122-134. 2011.

Yusuf I, Kageyama R, Monticelli L, Johnston RJ, Ditoro D, Hansen K, Barnett B, Crotty S. Germinal Center T Follicular Helper Cell IL-4 Production is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150). J Immunol 185(1):190-202. 2010.

Monticelli LA, Yang Y, Knell J, D'Cruz LM, Cannarile MA, Engel I, Kronenberg M, Goldrath AW. Transcriptional Regulator Id2 Controls Survival of Hepatic NKT Cells. PNAS 106(46):19461-6. 2009.

Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong H, Kang S, Macdougald O, Goldrath AW, Tontonoz P. Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-γ Expression and Adipocyte Differentiation. Molecular Endocrinology 22 (9): 2038-2048. 2008.

Peter Morawski

Peter Morawski
B.A. Biology, La Salle University (2008)

Matriculated: 2008
Thesis Advisor: Andrew Wells
Research Interests: Epigenetic & post-translational modification of Foxp3, Non-cell cycle role of CDK2, Cip/Kip & Ink4 families of cell cycle inhibitors

Ryan Moy
B.S. Molecular Biophysics and Biochemistry, Yale University (2008)
ryanmoy@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: David Artis
Research Interests: Innate immunity, mucosal immunology, RNA biology
Publications:
Weinberg Z, Wang JX, Bogue J, Yang J, Corbino K, Moy RH, and Breaker RR. Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes. Genome Biol 11: R31 (2010)

Sudarsan N, Lee ER, Weinberg Z, Moy RH, Kim JN, Link KH, and Breaker RR. Riboswitches in eubacteria sense the second messenger cyclic di-GMP. Science 321: 411-413 (2008)

Regulski EE, Moy RH, Weinberg Z, Barrick JE, Yao Z, Ruzzo WL, and Breaker RR. A widespread riboswitch candidate that controls bacterial genes involved in molybdenum and tungsten cofactor metabolism. Mol Microbiol. 68: 918-932 (2008)

Yu KM, Liu J, Moy R, Lin HC, Nicholas HB, and Rosenquist GL. Prediction of tyrosine sulfation in seven-transmembrane peptide receptors. Endocrine 19:333-338 (2002)

Martin Naradikian

Martin Naradikian
B.A. Biophysics, University of Pennsylvania (2007)

Matriculated: 2009
Current Rotation Advisor: Mike Cancro
Research Interests: B Cell Biology and Neuroimmunology

Shaun O'Brien

Shaun O'Brien
B.A. Molecular and Cell Biology, University of California, Berkeley (2004)
obriens@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Andrew Wells
Reserach Interests:T cells signaling/activation in context of disease
Publications:
Kavanagh B. et al., "CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion." Blood. 2008 Aug 15;112(4):1175-83. Epub 2008 Jun 3.

Aisling O'Hara

Aisling O'Hara
M.S. Biotechnology, Johns Hopkins University (2004)
B.S. Biology, Allegheny College (1999)
oharaa@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: Chris Hunter
Research Interests: T cell differentiation

Michael Oropallo
B.S. Biology, The College of New Jersey (2006)
mant@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: Mike Cancro
Research Interests: Immune Senescence B cell Homeostasis

Michael Paley

Michael Paley
B.S. Molecular biophysics and biochemistry, Yale University (2006)
mpaley@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor:John Wherry
Research Interests: CD8 T cell differentiation, Infectious diseases, Vaccines

Olivia Perng

Olivia A. Perng
B.S. Biochemistry, University of Texas at Austin (2004)
oliviaa@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: Andy Caton
Research Interests: Regulatory T cells, Tolerance and autoimmunity
Publications:
How specificity for self-peptides shapes the development and function of regulatory T cells. Simons DM, Picca CC, Oh S, Perng OA, Aitken M, Erikson J, Caton AJ. J Leukoc Biol. 2010 Dec;88(6):1099-107. Epub 2010 May 21. Review.

Efficient help for autoreactive B-cell activation requires CD4+ T-cell recognition of an agonist peptide at the effector stage. Hondowicz BD, Batheja AO, Metzgar MH, Pag‡n AJ, Perng OA, Willms S, Caton AJ, Erikson J. Eur J Immunol. 2009 Sep;39(9):2377-82.

Naomi Philip

Naomi Philip
B.A. Biology, Bryn MawrCollege (2009)
nphilip@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: Mike Betts
Research Interests: Host-pathogen interactions, innate immunity, autoimmunity

Natalia Ramos-Herndandez
B.S. Industrial Biotechnology, University of Puerto Rico (2008)
rnatalia@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Paula Oliver
Research Interests: Peripheral T cell tolerance, mucosal immunity

Sheila Rao
B.A. Molecular Biology, Colgate University (2006)
raoshe@mail.med.upenn.edu

Matriculated: 2008
Thesis Advisor: Ed Behrens/Gary Koretzky
Research Interests: Cell Signaling

Julia Rood

Julia Rood
B.A. Biology & Math, St. Olaf College (2007)
jrood@mail.med.upenn.edu

Matriculated: 2012
Current Rotation Advisor: Jeff Weiser
Research Interests: Infectious diseases, host-pathogen interaction

Keri Sanborn

Keri Beth Sanborn
B.S. Biology, Boston College (2006)
keri@mail.med.upenn.edu

Matriculated: 2006
Thesis Advisor: Jordan Orange
Research Interests: Role and regulation of myosin IIA in NK cell cytotoxicity.
Publications:
Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Mar 7. pii: 44862. doi: 10.1172/JCI44862.

Mentlik AN, Sanborn KB, Holzbaur EL, Orange JS. Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. Mol Biol Cell. 2010 Jul;21(13):2241-56.

Sanborn KB, Orange JS. Navigating Barriers: The Challenge of Directed Secretion at the Natural Killer Cell Lytic Immunological Synapse. J. Clin. Immunol. 2010, May;30(3):358-63. Review.

Sanborn KB, Rak GD, Mentlik AN, Banerjee PP, Orange JS. Analysis of the NK cell immunological synapse. Methods Mol. Biol. 2010;612:127-48. PMID: 20033638

Savic V, Sanborn KB, Orange JS, Bassing CH. Chipping away at gamma-H2AX foci. Cell Cycle. 2009 Oct 15;8(20):3285-90. PMID: 19770593

Sanborn KB, Rak GD, Maru SY, Demers K, Difeo A, Martignetti JA, Betts MR, Favier R, Banerjee PP, Orange JS. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. J Immunol. 2009 Jun 1;182(11):6969-84. PMID: 19454694

Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, Hardy GA, Orange JS, Betts MR. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. J Immunol. 2009 May 1;182(9):5560-9. PMID: 19380804

Amanda Schmidt

Amanda Schmidt
B.S. Microbiology, University of Minnesota (2008)
schmidta@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor:Taku Kambayashi
Research Interests: Regulatory T cell homeostasis, mast cell signal transduction, cell/cell interactions

Jonathan Silver

Jonathan Silver
B.S. Biology, Chemistry Minor, University of North Carolina, Chapel Hill (2005)
js.upenn@gmail.com

Matriculated: 2005
Thesis Advisor: Chris Hunter
Research Interests: The function of gp130 and IL-6 during infection-induced inflammation
Publications:
Stumhofer JS, Silver JS, Laurence A., Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O’Shea JJ and Hunter CA. Interleukins 27 and 6 induce STAT3-mediated T cell production of Interleukin 10. Nature Immunology. 2007 Dec;8(12):1363-71.

Stumhofer JS, Silver J and Hunter CA. Negative regulation of Th17 responses. Semin. Immunology. 2007 Dec;19(6):394-9.

Silver JS and Hunter CA. With a little help from their friends: interleukin-21, T cells and B cells. Immunity. 2008 Jul;29(1):7-9.

Bunch DO, Silver JS, Majure MC, Sullivan P, Alcorta DA, Chin H, Hogan SL, Lindstrom YI, Clarke SH, Falk RJ and Nachman PH. Maintenance of tolerance by regulation of anti-myeloperoxidase B cells. J Am Soc Nephrol. 2008 Sep;19(9):1763-73.

Carvalho SP, Silver JS, O’hara AC, Stumhofer JS and Hunter CA. IL-6 promotes NK Cell Production of IL-17 during Toxoplasmosis. J Immunol. 2010 Feb 15;184(4):1776-83.

Silver JS and Hunter CA. Gp130 at the nexus of inflammation, autoimmunity and cancer. Journal of Leukocyte Biology. 2010 Dec;88(6):1145-56

Silver JS, Stumhofer JS, Ernst M and Hunter CA. Exaggerated gp130-mediated signaling antagonizes early resistance to Toxoplasma gondii. (in press; Journal of Immunology).

Greg Sonnenberg

Greg Sonnenberg
B.S. Biomedical Sciences, The State University of New York at Buffalo (2007)
gfield@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: David Artis
Publications:
Sonnenberg, G.F., Nair, M.G., Kirn, T.J., Zaph, C., Fouser, L.A., Artis, D. (2010) Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. Journal of Experimental Medicine 207:1293-1305. [PMID: 20498020].

Sonnenberg, G.F., Fouser, L.A., Artis, D. (2010) Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces. Advances in Immunology 107:1-29. [PMID: 21034969].

Sonnenberg, G.F., Monticelli, L.A., Elloso, M.M., Fouser, L.A., Artis, D. (2011) CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 34:122-134. [PMID: 21194981].

Sean Spencer

Sean Spencer
B.S. Medical Microbiology and Immunology, University of Wisconsin, Madison (2007)
seanspen@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: Yasmine Belkaid
Research Interests: Eosinophils, Tissue homeostasis, Immunoregulation, T cell differentiation

Natalie Steinel

Natalie Steinel
B.S. Cell and Molecular Biology & B.A. French, University of Texas (2003)

Matriculated: 2008
Thesis Advisor: Craig Bassing
Publications:
Tomayko MM, Steinel NC, Anderson SM, Shlomchik MJ. Cutting edge: Hierarchy of maturity of murine memory B cell subsets. J Immunol. 2010 Dec 15;185(12):7146-50.

Brady BL*, Steinel NC*, Bassing CH. Antigen receptor allelic exclusion: an update and reappraisal. J Immunol. 2010 Oct 1;185(7):3801-8.

Steinel NC, Brady BL, Carpenter AC, Yang-Iott KS, Bassing CH. Posttranscriptional silencing of VβDJβCβ genes contributes to TCRβ allelic exclusion in mammalian lymphocytes. J Immunol. 2010 Jul 15;185(2):1055-62.

Yang-Iott KS, Carpenter AC, Rowh MA, Steinel N, Brady BL, Hochedlinger K, Jaenisch R, Bassing CH. TCRβ feedback signals inhibit the coupling of recombinationally accessible Vβ14 segments with DJβ complexes. J Immunol. 2010 Feb 1;184(3):1369-78.

Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA. RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobin loci. Nat Immunol. 2009 Jun;10(6):655-64.

Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ 3rd, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15517-22.

Tomayko MM, Anderson SM, Brayton CE, Sadanand S, Steinel NC, Behrens TW, Shlomchik MJ. Systematic comparison of gene expression between murine memory and naïve B cells demonstrates that memory B cells have unique signaling capabilities. J Immunol. 2008 Jul 1;181(1):27-38.

Brittany Weber

Brittany Weber
University of Oklahoma (2007)
weberbn@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor: Avinash Bhandoola
Research Interests: Early T cell development
Publications:
Maeda K, Malykhin A, Teague-Weber BN, Sun XH, Farris AD, Coggeshall KM. (2009) Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood. 2009 May 7;113(19):4534-40

Teague, BN., Pan, Y, Mudd PA, Nakken, B, Zhang, Q, Szodoray, P, Kim-Howard, X, Wilson, PC., Farris, AD. (2007) Cutting Edge: Transitional T3 B Cells Do Not Give Rise to Mature B Cells, Have Undergone Selection, and Are Reduced in Murine Lupus. J Immunol 2007 178: 7511-7515

Mudd, P. A., Teague, B. N. & Farris, A. D. (2006) Regulatory T Cells and Systemic Lupus Erythematosus. Scandinavian Journal of Immunology 64 (3), 211-218.

Kate Weissler

Katherine Weissler
B.S. Biology, University of Virginia (2009)
kweis@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor:Andy Caton
Research Interests: Regulatory T cells and infectious disease

Karla Wiehagen

Karla Wiehagen
University of Missouri, Columbia (2006)
krose@mail.med.upenn.edu

Matriculated: 2007
Thesis Advisor: Jonathan Maltzman
Research Interests: The role of transcription factor Foxp4 in T cell development and function
Publications:
Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells. Wiehagen KR, Corbo E, Schmidt M, Shin H, Wherry EJ, Maltzman JS. Blood 2010 Dec 16;116(25):5560-70. Epub 2010 Sep 30.

Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Feng X, Ippolito GC, Tian L, Wiehagen K, Oh S, Sambandam A, Willen J, Bunte RM, Maika SD, Harriss JV, Caton AJ, Bhandoola A, Tucker PW, Hu H. Blood. 2010 Jan 21;115(3):510-8. Epub 2009 Nov 12.

Katie Williams

Katie Williams
B.S. Biology, University of New Hampshire (2005)
wkatie@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor:Jan Erikson
Research Interests: B cells and infectious disease

Christine Wilson

Christine Wilson
B.S. Biology, Howard University (2009)
wilc@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor: Luis Montaner
Research Interests: Innate immunity, immunity to infectious disease, host-pathogen interaction, vaccine development, granulocyte biology
Publication:
Saini RV, Wilson C, Finn MW, Wang T, Krensky AM, Clayberger C. "Granulysin delivered by cytotoxic cells damages endoplasmic reticulum and activates caspase-7 in target cells." J Immunol. 2011 Mar 15;186(6):3497-504. Epub 2011 Feb 4.

En Jun Yang

En Jun Yang
B.S. Biology, University of Michigan, Ann Arbor (2009)
enjyang@mail.med.upenn.edu

Matriculated: 2010
Current Rotation Advisor:Taku Kambayashi
Research Interests: Autoimmunity and Tolerance

Shirley Zhang
B.A. Biochemistry, New York University (2009)
zhangshi@mail.med.upenn.edu

Matriculated: 2009
Thesis Advisor:Avinash Bhandoola
Research Interests: Early thymocyte development, progenitor trafficking to the thymus

Rena Zheng
B.A. Biology, University of Pennsylvania (2007)

Matriculated: 2009
Thesis Advisor: Gerd Blobel
Research Interests: Regulation of erythropoiesis and liver development by GATA factors
Publications:
Banerjee PP, Pandey R, Zheng R, Suhoski MM, Monaco-Shawver L, Orange JS. Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. J Exp Med. 2007 October 1; 204(10): 2305-2320.

Tao Zhou

Tao Zhou
B.S. Biology, Emory University (2005)

Matriculated: 2007
Thesis Advisor:Gary Koretzky and Taku Kambayashi
Research Interests: Regulatory T cells

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