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Willliam M. Armstead, Ph.D.
Research Associate Professor
Department of Anesthesia
3400 Spruce Street
(215) 573-3674, FAX (215) 349-5078
email: armsteaw@uphs.upenn.edu
Click here for selected publications since Dr. Armstead's arrival at Penn
RESEARCH INTERESTS
Control of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury and cerebral ischemia/reperfusion.RESEARCH TECHNIQUES
Closed cranial window for measurement of pial artery diameter and collection of cortical periarachnoid CSF for vasoactive metabolite concentration determination by RIA, fluid percussion brain injury, global cerebral ischemia, radiolabelled microsphere regional cerebral blood flow determination.RESEARCH SUMMARY
My laboratory is interested in characterizing the role of several vasoactive systems (opioids, endothelin, prostaglandins) in impaired cerebral hemodynamic control following fluid percussion brain injury, a mimic of shaken impact syndrome, as a function of age in an in vivo model. My laboratory is also interested in characterizing the contribution of these same vasoactive systems to altered cerebral hemodynamic control following global cerebral hypoxia/ischemia in a newborn animal model. The latter injury model mimics the hypoxia/ischemia that may occur in the neonate with problems associated with delivery or respiratory management post delivery.
KEY WORDS:
opioids, newborn, brain injury, endothelin, nitric oxide, cerebral circulation
