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John A. Detre, M.D.

Assoc Professor of Neurology & Radiology
3 W Gates Building
3400 Spruce Street
(215) 349-8465 FAX: (215) 349-5579
email:   detre@mail.med.upenn.edu
For more information: http://www.cfn.upenn.edu

Click here for selected publications since Dr. Detre's arrival at Penn



RESEARCH INTERESTS

Physiology and pathophysiology of functional activation; clinical applications of functional MRI

RESEARCH TECHNIQUES

Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure.

RESEARCH SUMMARY

Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, and strokes. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods. There is a large component of data analysis and processing using statistical parametric mapping and other computational methods. In addition, the physiological basis and pathophysiological influences on functional activation are studied using a rat model. The research is carried out in collaboration with investigators from Radiology Research, the Cerebrovascular Research Center, Cognitive Neurology, and the Epilepsy Center.

KEY WORDS:
magnetic resonance, brain mapping, cerebral blood flow, brain injury

 

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