John
A. Detre, M.D.
Assoc Professor of Neurology & Radiology
3 W Gates Building
3400 Spruce Street
(215) 349-8465 FAX: (215) 349-5579
email: detre@mail.med.upenn.edu
For more information: http://www.cfn.upenn.edu
Click here for selected publications since Dr. Detre's arrival at Penn
RESEARCH INTERESTS
Physiology and pathophysiology of functional activation; clinical applications
of functional MRI
RESEARCH TECHNIQUES
Magnetic resonance imaging and spectroscopy with an emphasis on magnetic
resonance techniques used to image brain function in addition to brain structure.
RESEARCH SUMMARY
Overall research focuses on cerebral blood flow and metabolism under normal
and conditions and in response to brain injury. Specific conditions under
investigation include functional activation of human brain in response to
cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, and
strokes. This research primarily utilizes magnetic resonance techniques
including functional imaging techniques and spectroscopy, often correlated
with other methods. There is a large component of data analysis and processing
using statistical parametric mapping and other computational methods. In
addition, the physiological basis and pathophysiological influences on functional
activation are studied using a rat model. The research is carried out in
collaboration with investigators from Radiology Research, the Cerebrovascular
Research Center, Cognitive Neurology, and the Epilepsy Center.
KEY WORDS:
magnetic resonance, brain mapping, cerebral blood flow, brain injury
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