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Mark
I. Friedman, Ph.D.
Member and Associate Director,
Monell Chemical Senses Center
3500 Market Street/3308
(215) 898-4201 FAX: (215) 898-2084
email: friedman@monell.org
Click here for selected publications since Dr. Friedman's arrival at Penn
RESEARCH INTERESTS
Metabolic control of feeding behavior; overeating and obesityRESEARCH TECHNIQUES
In vitro and in vivo metabolic/nutritional biochemistry; NMR spectroscopy; calcium imaging; immunohistochemistry; behavioral assessmentRESEARCH SUMMARY
Research in my laboratory is directed at (1) characterizing the metabolic event in liver that constitutes a stimulus controlling food intake; (2) identifying the receptor mechanism that detects this stimulus; (3) elucidating the mechanisms that transduce this stimulus into a neural signal; (4) describing the neural pathways processing this information; and (5) determining whether and how this metabolic control of food intake plays a part in overeating(obesity) and other eating disorders. To examine the metabolic control of eating behavior, metabolism is altered using endocrine, dietary and pharmacological manipulations, and the effects on food intake, hepatic metabolism, the peripheral autonomic nervous system, and the brain are assessed by combining behavioral, biochemical, and anatomic techniques.
KEY WORDS:
Appetite; metabolism; liver; ATP; vagus
