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Joel
H. Greenberg, Ph.D.
Research Professor of Neurology,
Department of Neurology
School of Medicine
415 Stemmler Hall/6063
(215) 662-6351 FAX: (215) 349-5629
email: joel@med.upenn.edu
Click here for selected publications since Dr. Greenberg's arrival at Penn
RESEARCH INTERESTS
Cerebrovascular physiology in both normal states and pathophysiological
states; positron emission tomography; metabolic tissue changes during cerebral
ischemia; activation-flow coupling; functional reorganization following
ischemia RESEARCH TECHNIQUES
Quantitative multiple label autoradiography; local cerebral glucose metabolism; regional blood flow utilizing radio labeled microspheres; positron emission tomography (PET); single photon emission tomography; measurement of nitric oxide in vivo; small animal stroke models;optical imaging of blood flow and oxygenRESEARCH SUMMARY
Stroke: A crucial factor determining the prognosis of patients in cerebral ischemia is the ability of tissue to recover from biochemical and hemodynamic derangements. We are investigating the factors that contribute to irreversibility of tissue damage in focal cerebral ischemia. Studies are being conducted in cats and rats in which the middle cerebral artery is temporarily occluded. Parameters that are measured include local cerebral glucose metabolism, local cerebral blood flow, tissue metabolites (high energy phosphates) and, tissue nitric oxide concentrations. These parameters are correlated with regional histological damage.Activity dependent plasticity studies are being undertaken in the rat to examine the effect of somatosensory deafferentation on the relationship between local cerebral blood flow and local cerebral glucose metabolism. Double label autoradiography is being used.
Studies are currently in progress to examine reorganization of the blood
flow, metabolic, and functional response following focal cerebral ischemia
of the somatosensory cortex of the rat. A novel compression ischemia model
has been developed to facilitate these studies.
KEY WORDS:
Cerebral blood flow; cerebral ischemia; glucose metabolism; emission tomography; nitric oxide; reorganization
