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Tejvir
S. Khurana, M.D., Ph.D.
Department of Physiology & Pennsylvania Muscle Institute
A601 Richards Building
(215) 573-2640
email:
tsk@mail.med.upenn.edu
LINK TO KHURANA LAB SITE: http://www.uphs.upenn.edu/pmi/members/khurana/lab%20page.htm
RESEARCH INTERESTS
Duchenne Muscular dystrophy, Synapse-specific gene regulation, Extraocular muscle, utrophin, myostatin, gene therapyRESEARCH TECHNIQUES
Cloning genes, DNA-microarrays and GeneChip screening, promoter analysis, expression of recombinant proteins, generation of antibodies, imaging, physiological evaluation of muscleRESEARCH SUMMARY
We study molecular mechanisms underlying muscle specializations and patho-physiology of muscle diseases. Topics include developmental changes of muscle as a whole that lead to the formation of unique skeletal muscle group such as the extraocular muscle (EOM), control of muscle size by growth / developmental factors, as well as formation of neuromuscular junctions (NMJ). This research is also interesting from a disease perspective since some of these molecules / pathways (e.g. myostatin, utrophin) offer therapeutic strategies for muscular dystrophy.