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Scott Manaker, M.D., Ph.D.
Associate Professor, Dept of Medicine
School of Medicine
100 Centrex/HUP
(215) 662-3201 FAX: (215) 349-5084
email: scott.manaker@uphs.upenn.edu
Click here for selected publications since Dr. Manaker's arrival at Penn
RESEARCH INTERESTS
Neural control of respiration, central integration of autonomic functions;
brainstem neuroanatomy and neuropharmacology RESEARCH TECHNIQUES
Quantitative receptor autoradiography; neurotoxins; in situ hybridization; immunocytochemistry; tract tracingRESEARCH SUMMARY
The central theme of Dr. Manaker's laboratory was the neurobiology of respiration.
One major project focused on delineating the neural pathways from the caudal
raphe nuclei to upper airway cranial motoneurons, which may mediate reductions
of upper airway tone during REM sleep and, therefore, play a role in the
pathogenesis of apnea. A second project focused on the neurochemical integration
of vagal afferents in the nucleus of the solitary tract.
KEY WORDS:
Respiration, control of breathing, sleep apnea, upper airway
