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Martin Reivich, M.D.

RESEARCH INTERESTS

RESEARCH TECHNIQUES

RESEARCH SUMMARY

My research interests center around the regulation of cerebral circulation and metabolism in normal and pathological states. This involves both clinical investigations and studies in animals. The former involves studies in patients with cerebrovascular disease, aging, dementia, Parkinson's disease, schizophrenia, depression, substance abuse and epilepsy, as well as studies in normal subjects. Measurements of regional cerebral blood flow utilizing PET, SPECT, and the Xenon 133 inhalation technique are being performed in addition to PET studies of oxygen metabolism, glucose metabolism and neuroreceptor studies. The animal studies utilize an animal model of stroke in the cat and rat in which the middle cerebral artery is occluded. In these studies regional cerebral blood flow and glucose metabolism are studied autoradiographically. In addition, flow measurements are made utilizing microspheres and Doppler flowmeters. Cortical redox state, extracellular pH and potassium, tissue metabolites and histologic and clinical outcome are also measured. The potential protective effect of a number of agents are being examined in this model. These include calcium channel blockers, gangliosides, excitatory amino acid inhibitors and nitric oxide synthase inhibitors.

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