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Steven J. Siegel, M.D., Ph.D.
Department of Psychiatry
Translational Research Laboratory
125 South 31st Street
University of Pennsylvania
Philadelphia, PA 19104
Tel: (215) 573-0278
Fax: 215- 573-2041
email: siegels@mail.med.upenn.edu
Click here for selected publications since Dr. Siegel's arrival at Penn
RESEARCH INTERESTS
Neurobiology of schizophrenia and development of new treatment modalities
including long term delivery systems.RESEARCH TECHNIQUES
Auditory evoked potentials in awake mice following stereotaxic implantation of electrodes in hippocampus. HPLC and UV spectroscopy for drug concentrations following drug delivery design. Immunocytochemistry to evaluate drug and gene effects.Western blot analysis for quantitative measures of changes in protein expression
RESEARCH SUMMARY
The Stanley Center for Experimental Therapeutics in Psychiatry is a multidisciplinary research program that develops new treatments and examines the neurobiology of Schizophrenia.Long Term Drug Delivery - Medication non-adherence is a major reason for poor outcome in schizophrenia. We have developed a subcutaneous implant that delivers medicine for up to 14 months. We are also working as part of The Nanotechnology Institute to create a pill that will deliver medication for two weeks.
Animal Models of Brain Abnormalities in Schizophrenia we are studying possible brain abnormalities in schizophrenia in an effort to improve future treatments. Current projects examine the genetics and cellular biology of abnormal sensory processing that is found in schizophrenia using auditory evoked potentials in mice.
