Institute of Neurological Sciences

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				A B C D E F G H-K L M N-O P-Q R S T U-Z Ted Abel, PhD Dept of Biology: Genetic approaches to study the molecular basis of synaptic plasticity, learning and memory Rexford S. Ahima, MD, PhD Division of Endocrinology, Diabetes & Metabolism: Neural circuits for feeding and body weight regulation; interrelationship between central energy homeostatic mechanisms and hormones; neural basis of metabolic phenotypes Clay Armstrong, MD Dept of Physiology: Ionic channels and their gating mechanisms Steven E. Arnold, MD Dept of Neurology: Cellular and molecular neurobiology of schizophrenia and mood disorders, aging and neurodegenerative dementias B top of page Tracy L. Bale, PhD Veterinary Medicine: Examine the effects of stress sensitivity on the development and treatment of depression. Determine the molecular mechanisms by which stress factors influence appetite and metabolism. Examine the effects of maternal stress-sensitivity on fetal development and long-term physiological and behavioral responses. Rita Balice-Gordon, PhD Dept of Neuroscience: Activity-dependent synaptic plasticity during neural development, using neuromuscular and cns synapses as model systems; neurotrophic and other cell-cell signaling mechanisms underlying synapse formation and maintenance Greg Bashaw, PhD Dept of Neuroscience: Molecular mechanisms of axon growth and guidance during nervous system development. We are interested specifically in how axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone to generate a directed motile response. Stephen M. Baylor, MD Dept of Physiology: Excitation-contraction coupling in muscle; measurement of intracellular ionic concentrations Sheryl G. Beck, PhD Children's Hospital of Philadelphia: Effects of stress, antidepressants and corticosteroids on serotonergic-limbic system pathways Jean Bennett, MD, PhD Dept of Ophthalmology: Genetics, pathology and treatment of inherited retinal degenerations Julie Blendy, PhD Dept of Pharmacology: molecular basis of drug abuse Kwabena A. Boahen, PhD Depts of Bioengineering and Electrical Engineering: Designing mixed analog-digital, multichip, microelectronic systems that model the structure and function of early stages of the visual and auditory pathways Nancy Bonini, PhD Dept of Biology: Molecular genetics of neurodegenerative disease David H Brainard, PhD Dept of Psychology: Visual perception and its neural mechanisms; digital image processing Edward S. Brodkin, MD Dept of Psychiatry: Neurobiology of social behaviors, including aggressive and affiliative behaviors, studied using genetic analysis in mouse model systems. Neurobiology and genetics of autism spectrum disorders Amy Brooks-Kayal, MD Dept of Neurology & Pediatrics: Developmental and Molecular Neuroscience, Epilepsy Maja Bucan, PhD Depts of Psychiatry, Genetics: Genetic dissection of complex behaviors in mice; Functional genomics C top of page Anjan Chatterjee, MD Dept of Neurology: The cognitive neuroscience of spatial attention and representation, the neural basis of language, and the relationship of space and language Akiva Cohen, PhD Dept of Pediatrics: Brain excitability and circuit rearrangement and their alterations observed under pathophysiology Diego Contreras, MD, PhD Dept of Neuroscience: Representation of information in corticothalamic networks. Epilepsy. Edward C. Cooper, MD, PhD Dept of Neurology: Regulatory mechanisms of ion channels; localization of ion channels in the mammalian CNS; molecular mechanisms through which abnormalities of CNS ion channels contribute to neurological disease Douglas A. Coulter, PhD Dept of Pediatrics, Division of Neurology: Epilepsy, neuronal excitability, CNS rhythm generation, GABA receptors, development of neurotransmitter receptors and ion channels, synaptic function Bryan Crenshaw, PhD Mammalian Neurogenetics Lab/CHOP: Analysis of the role of developmental regulatory factors during mouse embryonic development Peter B. Crino, MD, PhD Dept of Neurology: Cortical maldevelopment as it relates to epilepsy, mental retardation, and autism; The Tuberous Sclerosis Complex; Brain tumors D top of page Matthew Dalva, PhD Dept. of Neuroscience: Cellular and molecular mechanisms guiding the process of synapse formation between CNS neurons; Roles of activity-dependent and activity-independent cues in cell-cell interaction in synapse development. John A. Detre, MD Dept of Neurology & Radiology: Cerebral blood flow and metabolism under normal and pathophysiological conditions; functional activation of human brain; cerebrovascular disease and stroke modeling Marc A. Dichter, MD, PhD Dept of Neurology: Epilepsy; cortical physiology; regulation of synaptic function; Joshua Dunaief, MD, PhD Dept of Ophthalmology: Age-related macular degeneration (AMD), oxidative stress in retinal disease, retinal iron metabolism, apoptosis in the retina. E top of page James H. Eberwine, PhD Dept of Pharmacology: Molecular basis of neuronal adaptation with emphasis on the following adaptive processes; tetanic potentiation, glucocorticoid-induced, age-induced as well as opiate-induced adaptation Russell Epstein, PhD Dept of Psychology: Neural bases of scene perception and spatial cognition in humans. F top of page Martha J. Farah, PhD Dept of Psychology: Cognitive neuroscience , neuroethics Leif Finkel, MD, PhD Dept of Bioengineering: Computer neuroscience and neuroengineering Lori Flanagan-Cato, PhD Dept of Psychology: Steroid-induced plasticity of neural circuits to control reproductive and ingestive behaviors Steven J. Fluharty, PhD Dept of Animal Biology: Regulation of neuropeptide receptor gene expression and signal transduction in cultured neuronal cells and behaving animals Kevin Foskett, PhD Dept of Physiology: Molecular physiology of the inositol trisphosphate receptor calcium release channel and the cystic fibrosis chloride channel Marcos Frank, PhD Dept of Neuroscience: The function of sleep in developing and adult animals. G top of page Alan Gelperin, PhD Member, Monell Chemical Senses Center: Synaptic plasticity and learning. Olfactory information processing in the CNS. Electronic olfaction. Computational neuroscience. Joshua Gold, PhD How the brain forms decisions about sensory stimuli: What are the underlying neural computations? Where are the circuits that perform these computations? How are these circuits shaped by experience Jeffrey A. Golden, MD Dept of Pathology: Patterning and Cell Migration in the Developing Nervous System Francisco A. González-Scarano, MD Dept of Neurology: Viral determinants of neurotropism in two systems: human immunodeficiency virus and La Crosse Bunyavirus Michael Granato, PhD Dept of Cell and Developmental Biology: Genetic control of axonal guidance in the zebrafish; the zebrafish as a model system for motor behavior regulation in psychiatric diseases Harvey J. Grill, PhD Dept of Psychology: Neural control of nutrient intake; gastrointestinal physiology; pharmacology of intake and gastrointestinal function Judith B. Grinspan, PhD Dept of Neurology: Origin and development of oligodendroglia and synthesis of myelin; control of proliferation, differentiation and survival of the oligodendroglial lineage; plasticity of oligodendroglia; programmed cell death in myelinating cells. H-K top of page Joan C. Hendricks, PhD Behavioral, gene expression profiling, and biochemical assays to characterize correlates of states of arousal in Drosophila; mutagenesis to identify genes involved in sleep-like rest homeostasis; drug testing and mutagenesis for novel mechanisms of wake promotion. Toshinori Hoshi, PhD Dept of Physiology: Oxidative regulation of neuronal excitability; ion channel gating; protein oxidative damage and aging. Harry Ischiropoulos, Ph.D. Dept. of Pediatrics, Biochemistry and Biophysics: Oxidative stress, post-translational protein modifications and protein aggregation in neurodegenerative diseases. Non-invasive discovery and validation of disease biomarkers. Amishi Jha, PhD Dept of Psychology: Neural basis of human memory and attention Kelly L. Jordan-Sciutto, PhD Dept of Pathology: Assessing mechanisms of neuronal death (apoptosis vs necrosis in response to neuroinflammotry mechanisms and oxidative stress and protection by neurotrophins to gain insight into the molecular mechanisms underlying neuronal loss in neurodegenerative Disorders (i.e. Alzheimer's Disease, Parkinson's disease, and HIV encephalitis). We are specifically interested in the role of cell cycle proteins and transcriptional regulators in neuronal survival decisions Michael J. Kahana, PhD Dept of Psychology: Human memory and its neural mechanisms; Brain Oscillations Robert Kalb, MD Dept of Pediatrics, CHOP: Biology of nerve cells in the vertebrate central nervous system Daniel S. Kessler, PhD Vertebrate development; signal transduction; transcriptional regulation; primary germ layers; Spemann's organizer. L top of page Virginia M.-Y. Lee, PhD Department of Pathology and Laboratory Medicine: Biology of tau, synucleins and amyloid beta precursor proteins (APPs) in health and disease Irwin B. Levitan, PhD Department of Neuroscience: Modulation of neuronal activity and neuronal ion channels Jon M. Lindstrom, PhD Department of Neuroscience: The structure of nicotinic acetylocholine receptors from muscles and nerves; the autoimmune response to muscle nicotinic receptors in myasthenia gravis; nicotine-induced upregulation of nicotinic receptors Zhe Lu, MD, PhD Dept of Physiology: Molecular mechanisms of potassium channels and retinal cGMP-activated channels Irwin Lucki, PhD Department of Psychiatry and Psychology: (1) Behavioral pharmacology; (2) Mechanism of action of antidepressant and antianxiety medications; (3) Stress neurobiology and psychiatric disorders David R. Lynch, MD Dept of Neurology & Pediatrics: NMDA receptors M top of page Minghong Ma, PhD Dept of Neuroscience: Cellular and molecular mechanisms underlying the sense of smell (olfaction) in mammals. Richard R. Miselis VMD, PhD Dept of Animal Biology: Neuroanatomy; visceral neuraxis; ingestive behaviors; homeostasis N-O top of page Robert W. Neumar, MD, PhD Dept of Emergency Medicine: Mechanisms of neuronal injury after cardiac arrest and stroke. Current research projects include investigation of: 1) the mechanism and consequences of disrupted calcium homeostasis in post-ischemic neurons, 2) the role of calpain and caspase proteolytic cascades in post-ischemic neuronal death. Michael Nusbaum, PhD Dept of Neuroscience: Neural network modulation; motor pattern selection from multifunctional networks; local, presynaptic influences; neuropeptide function Ana Lia Obaid, PhD Dept of Neuroscience: Optical measurements of electrical activity; excitation-secretion coupling; simple nervous systems in vitro; enteric nervous system P-Q top of page Allan I. Pack, MD, PhD Dept of Medicine: Neural control of respiration; effect of sleep on neural control of respiration, sleep apnea syndrome Larry A. Palmer, PhD Dept of Neuroscience: Cortical circuits mediating direction and orientation selective responses and responses from outside the classical receptive field in visual cortex. Thomas D. Parsons VMD, PhD Dept of Clinical Science: Cellular and molecular mechanisms of neurotransmitter release Laura L. Peoples, PhD Behavioral pharmacology, neuropharmacology; electrophysiological recordings in freely-moving animals. Randall N. Pittman, PhD Dept of Pharmacology: Cellular and molecular events in neural apoptosis and polyglutamine repeat expansion neurodegenerative diseases. Edward N. Pugh, PhD Dept of Ophthalmology: Photoreceptor transduction in rods and cones; early processes in human color vision; polarization vision in vertebrates; "polarization contrast" vision R top of page Jonathan A. Raper, PhD Dept of Neuroscience: Developmental neurobiology; growth cone guidance; cell recognition; cell motility; and regeneration Virginia M. Richards, PhD Dept of Psychology: Auditory perception; decision processes Michael Robinson, PhD Dept of Pediatrics and Pharmacology: Signaling pathways that regulate glutamate transporters and the relationship of these transporters to acute brain injury S top of page Brian Salzberg, PhD Dept of Neuroscience: Optical probes of membrane potential James C. Saunders, PhD Dept of Otorhinolaryngology: Psychobiology and neurobiology of hearing Steve Scherer, MD, PhD Dept of Neurology: Axon-Schwann cell interactions in developing and regenerating peripheral nerve Marc Schmidt, PhD Dept of Biology: Encoding of complex motor behaviors; auditory/motor integration; neural basis of vocal learning Amita Sehgal, PhD Dept of Neuroscience: Genetic and molecular mechanisms underlying circadian rhythms in Drosophila Michael E. Selzer, MD, PhD Dept of Neurology: Spinal cord regeneration in lampreyt Steven J. Siegel, MD, PhD Division of NeurophyshiatryNeurobiology of schizophrenia and development of new treatment modalities including long term delivery system Peter Sterling, PhD Dept of Neuroscience: Microcircuitry of the visual system T top of page J. Paul Taylor, MD, PhD Dept of Neurology: The molecular basis of neurodegenerative diseases, development of target-based therapeutics Steven A. Thomas, MD, PhD Dept of Pharmacology: The roles of neurotransmission in development, neurophysiology and ultimately behavior Sharon L. Thompson-Schill, PhD Dept of Psychology: Neural bases of memory and language in humans John Q. Trojanowski, MD, PhD Dept of Pathology and Laboratory Medicine: Cytoskeletal protein abnormalities in normal maturing, developing, aging, and neoplastic neurons U-Z top of page Rita J. Valentino, PhD Department of Pediatrics: Neurobiology of stress and mechanisms of stress-related psychiatric disorders; central control of visceral functions Noga Vardi, PhD Dept of Neuroscience: Retinal processing - how anatomical and chemical circuit architecture code and transfer information Frank A. Welsh, PhD Dept of Neurosurgery/Surgery: Molecular mechanisms of ischemic brain damage. Treatment of the ischemic brain. Role of stress proteins in the cellular defense against ischemia. Development of RNA therapy to overexpress specific proteins in the brain. John H. Wolfe, VMD, PhD Dept of Pathology and Medical Genetics: Somatic gene transfer and therapy for the central nervous system For general inquiries and information, please contact Jane Hoshi.