Funding Opportunities

 Upcoming Deadlines:

  • CHPS/JIPGP due Friday, March 2, 2018 @ 12pm — guidelines/instructions will be sent in January 2018.


Pilot Grant Application System


Center for Human Phenomic Science (CHPS), formerly CTRC, Junior Investigator Preliminary/Feasibility Grant Program (JIPGP)

 Applications due date: Friday, March 2, 2018, at 12pm. A full annoucement and guidelines will be available in January 2018.

The Center for Human Phenomic Science (CHPS) will soon be accepting research proposals to be considered for the Junior Investigator Preliminary/Feasibility Grant Program (JIPGP).

The primary goal of the Center for Human Phenomic Science (CHPS) Junior Investigator Preliminary/Feasibility Grant Program (JIPGP) is to encourage junior investigators to develop clinical research projects that will ultimately lead to competitive extramural funding and a career in Clinical Translational Research Center-focused clinical investigation.  The awards are designed to allow junior faculty members and M.D., Ph.D. or D.M.D post-doctoral trainees with appropriate mentors to obtain funds for pilot projects that are investigator-initiated, human-based, CHPS studies that will enable an applicant to obtain preliminary data.

The grants will be available at each institution effective June 1, 2018.

Award Dates:

  • Application Receipt Deadline: Friday, March 2, 2018 at NOON
  • Notification of Award: April 2018
  • Funding Period: 6-1-18 to 5-31-19

 JIPGP Guidelines and Submission Instructions 2017 (pdf)
Please see the attached full announcement for eligibility criteria, proposal instructions, documents (accessed by clicking on the paper clip) and additional details.

CHPS/ JIPG 2016-2017 Awardees (pdf)


CPHI/CEAR CTSA Pilot Grant Program

Application due date: Friday, May 6, 2016 at 5:00pm

The Center for Public Health Initiatives (CPHI) and the Community Engagement and Research (CEAR) core of the Clinical and Translational Science Award (CTSA) at the University of Pennsylvania are collaborating on a pilot grant program to fund research with public and community health relevance.

This call for proposals is to open faculty with significant public and community health-related experience at Penn and is intended to:

  • Foster interdisciplinary research in public health at Penn that will have meaningful results at the community level.
  • Assist in garnering external support for large-scale studies in the field of public health.
  • Encourage additional faculty and staff at Penn to become involved in public health research.
  • Identify the innovative methodologies in the field of public health that have the potential of informing local, state, and national policy and programming.

Applications are due May 6, 2016 by 5:00pm. Awarded grants will be in the range of $2,000 to $20,000.

All applicants should be submitted electronically to Sarah Green (shgreen@upenn.edu). Please see the attached call for proposals for complete details.


(HPS) Human Phenomic Science

 Application due date: Tuesday, May 23, 2017, at noon for a project start date of 7/1/2017.

The Institute for Translational Medicine and Therapeutics (ITMAT), the Penn Center for Precision Medicine, the Abramson Cancer Center (ACC) and the Department of Radiology plan to support pilot grants in the area of Human Phenomic Science (HPS).

  • Grants to support research that avails of the facilities of the Center for Human Phenomic Science (CHPS) are available to registered members of the ITMAT and the ACC as well as Associate Members who hold Instructor A or Research Associate positions.
  • Examples of the types of such research include (i) deep phenotyping studies designed to parse variability of response to therapeutic interventions; (ii)deep phenotyping n=1 studies of patients receiving investigative drugs on the basis of compassionate use; (iii) studies that interrogate multi-system disease to determine individual susceptibility such as cardiac complications of chemotherapeutic agents; (iv) studies that elucidate how environmental perturbations influence drug response such as studies of chronopharmacology or drug – diet interactions and (v) studies of multimodal combinatorial therapies.
  • All proposals are due by May 23, 2017 at noon for a project start date of July 1, 2017.

HPS Instructions (pdf)
HPS Application (word)
HPS Budget Template (excel)

HPS 2017 Awardees (pdf)


Internal and External Funding Opportunities

There are many internal and external funding opportunities available for faculty and students. These opportunities can be viewed via the School of Medicine's portal and via the University's U@Penn Research Portal. This new feature, which is part of U@Penn, provides a single portal for investigators and administrators that is aimed at facilitating accessibility to research information.


MHB Maturational Human Biology Pilot Grant Program

Application due date: May 23, 2017 at 12pm.

The proposals must be interdisciplinary and translation in nature and bridge the pediatric to adult divide. All proposals must have at least two Co-Principal Investigators, including at least one from the University of Pennsylvania and at least one from The Children's Hospital of Philadelphia. The proposals are due May 23, 2017 at noon for a proposal start date of July 1, 2017.

MHB 2016-2017 Awardees (pdf)


PICAB Program in Comparative Animal Biology

 Application due date: Friday, December 8, 2017, at noon.

The Penn-CHOP CTSA Program in Comparative Animal Biology (PICAB) announces a pilot grant program between veterinary and human medicine to advance translational therapeutics. The purpose is to use naturally occurring domestic animal models of disease that are sufficiently similar to human diseases as a means to evaluate potential feasibility of novel treatments.

Many naturally occurring diseases in domestic animals are sufficiently similar to human diseases that they can be used to evaluate the feasibility of novel treatments. The emphasis is on molecular medicine approaches to therapy (gene therapy, stem cells, recombinant proteins) with the goal of generating sufficient preliminary data to support extramural grant applications. These proposals require co-PIs from the veterinary and the medical faculty (PSOM or CHOP). Two pilot grants of up to $45,000 each is available start date of February 1, 2018. Grants are due at noon on Friday, December 8, 2017.

Investigators who would like advice on potential partners in the other school may contact Dr. John H. Wolfe via Emily Romick at 215-590-7030 or emromick@vet.upenn.edu.

PICAB 2016-2017 Awardees (pdf)


SPIRiT

Application due date: Monday, May 15, 2017 at 5pm EDT

CTSA SPIRiT Call for Proposals
SPIRiT, the Sharing Partnership for Innovative Research in Translation, is pleased to announce a new funding program that supports pilot research projects representing collaborations between investigators from at least two of the SPIRiT sites. The SPIRiT Consortium members supporting this program include Johns Hopkins University, University of Chicago, University of Pennsylvania, University of Pittsburgh, Washington University in St. Louis, and Yale University – all members of the NIH Clinical and Translational Science Award (CTSA) Program. The investigator(s) from each of the participating sites must have a significant, defined role in the research project. Although the participating investigators may have collaborated in the past, the research project proposed must be novel and not part of an ongoing project. In other words, the proposed research must represent a new collaboration between investigators from at least two (2) SPIRiT sites OR a new project conducted by existing collaborators from at least two (2) SPIRiT sites. Proposed projects may address any aspect of clinical and translational science.

AVAILABLE FUNDING
The principal investigator from each individual SPIRiT institution may request up to $25,000 in direct costs from her/his institution for research efforts to be conducted at that institution over a one (1) year period. For example, a project that is being proposed by a team of investigators from three (3) SPIRiT sites can request up to $25,000 from each participating site for a total of $75,000 in direct costs. Monies will not be transferred from one institution to another. Additional budgetary restrictions may apply, as determined by policies and procedures at the individual participating SPIRiT institutions.

RESEARCH PLAN
Teams that respond to this solicitation must submit one overall Research Plan. The research plan must include the sections described below. Note: sections A-B must not exceed five (5) pages.

A. Specific Aims and Research Strategy: Concisely state the hypothesis to be tested and the Specific Aim(s) to be achieved during the award. Include a clear statement as to the aspects of the study that require or will be enhanced by participation of each SPIRiT institution. Meaningful collaboration from each site must be demonstrated. The Research Strategy should include: 1) Significance, 2) Innovation, and 3) Approach Sections.

B. Team Collaboration: Describe the team that has been assembled across the SPIRiT sites. If investigators from any SPIRiT sites are active collaborators, or have been in the past, briefly describe the collaborative research. The roles and administrative, technical, and scientific responsibilities for the project should be delineated for the Site PIs.

C. Milestones Table: Provide a table listing the project milestones, time frame for completion, and responsible Site PI for each. This table must be no more than one page in length.

REVIEW CRITERIA
Primary review criteria:

  • scientific feasibility and scientific merit of the project
  • potential to lead to more comprehensive studies
  • project is novel and is not simply a next logical step in ongoing studies
  • clearly defined and significant scientific roles for investigators from all participating sites

TIMELINE
Applications Due: May 15, 2017 (5:00 p.m. EDT)
Award Decisions: Late June, 2017
Award Start Date: July 1, 2017

SPIRIT 2017 Awardees (pdf)


TAPITMAT Transdisciplinary Awards Program in Translational Medicine and Therapeutics

 Application due date: Friday, December 8, 2017, at noon.

The Institute for Translational Medicine and Therapeutics (ITMAT) invites proposals from ITMAT Members and ITMAT Associate Members in the Research Associate or Instructor A category. It is not too late to become a Member or an Associate Member if you would like to apply for the grant and meet membership criterion. If you are interested, please visit the membership section of our website for details.

We will offer the Hwang Transdisciplinaray Award in Translational Medicine and Therapeutics during this funding cycle. This award will favor an application with particular potential for commercialization.

The proposals must center on the translational space – from proof of concept in cells or model systems through to mechanistic studies in humans elucidating human physiology or mechanisms of disease or, in drug development, parsing sources of variability in drug response and/or dose selection in Phase II.  Programs that plan to progress within that space and which deploy technologies and approaches conventionally segregated from each other within the traditional boundaries of academic medicine will be especially favored.  Proposals that focus on translational therapeutics or on bridging the pediatric to adult divide are particularly encouraged.

The proposals are due by December 8, 2017, for a proposal start date of February 1, 2018.

TAPITMAT 2016-2017 Awardees (pdf)


CBIT Chemical Biology in Translation

This award mechanism is currently not being offered.

Awardees

2009 TAPITMAT-CBIT Award Recipients [this was the last round of awards]

 Inhibiting the c-Myb Protooncogene (pdf)
(Alan Gewirtz, MD, Department of Medicine, School of Medicine)

 A High-throughput Chemical Screen to Discover Modifiers of TDP-43 Cellular Toxicity in a Yeast TDP-43 Proteinopathy Model (pdf)
(Aaron Gitler, PhD, Cell and Developmental Biology, School of Medicine)

 High Throughput Screening of the BRCA1-Associated BRCC36 Metalloprotease (pdf)
(Roger Greenberg, MD, PhD, Department of Cancer Biology, School of Medicine)


2008 CBIT Awardees

Cellular High Throughput Screeing (HTS) Assay for Duchenne's Muscular Dystrophy (DMD) Therapy
(Tejvir Khurana, PhD, Physiology, SOM)

Identifying Novel Promoters of Human MSC Osteo-Chondrogenesis through Chemical Library Screening Applications for Tissue Engineering
(Robert Mauck, MD, Orthopaedic Surgery, SOM and Jason Burdick, PhD, Bioengineering, SEAS)

Screening of Small Molecule Inhibitors of Complement
(Wenchao Song, PhD, Pharmacology, SOM)


2007 CBIT Awardees

Detection of caspase activation in zebrafish embryos, a sophisticated vertebrate for high-througput screening (HTS) of radiomodifying agents
(Dr. Gary D. Kao, Radiation Oncology, SOM)

Identifying selective ligands for prostacyclin-thromboxane receptor heterodimers
(Dr. Emer M. Smyth, Ph.D., Pharmacology, SOM)

Synthetic chemistry of Alzheimer Disease modulators
(Amos Smith PhD Chemistry, SEAS and Virgina Lee PhD, Pathology SOM)

Close section


CT³N Center for Targeted Therapeutics and Translational Nanomedicine

 Application due date: Friday, December 8, 2017, at noon.

CT3N invites PENN and CHOP researchers to submit competitive proposals for Pilot Grants by December 8, 2017. The goal of these Pilot Grants is to support early-stage experimental preclinical studies in targeted therapeutics and thus assist investigators in obtaining key data to seek extramural funding. The grants will be for $25,000 for one year, starting February 1, 2018.

Scope:
Preclinical (animal, cell culture and in vitro) experimental studies focused on the design of systems for targeted delivery of therapeutics and/or imaging agents and the identification of molecular targets for site-specific medical interventions. Proposals in the realms of both adult and pediatric biomedicine, and especially bridging the adult/pediatric medicine divide, are welcome.

Eligibility:
Applicants must be based in the University of Pennsylvania and be a full‐time faculty of PENN/CHOP. Joint proposals by co‐PIs from PENN /CHOP and CT3N members from other institutions (Drexel, Temple, Jefferson, PSU) will be considered. Applicants must be members of ITMAT and CT3N, and provide a written commitment to the CT3N activities including weekly journal club and monthly work‐in‐progress seminars. The PI’s lab can be based at any PENN School or at CHOP. Faculty members from all ranks and tracks are eligible to apply. Investigators in the rank of Senior Investigators and Research Associate may apply on the condition of providing approval letter from the Department Chair and letter from faculty member PI of the lab, assuring that a Research Associate’s project represents an independent new extension of the research area of this lab.

CT3N 2016-2017 Awardees (pdf)


CHIBE Pilot Grant Program

Enrollment:

Application due date: Friday, November 3, 2017 at 12pm.

The Institute for Translational Medicine and Therapeutics (ITMAT) and the LDI Center for Health Incentives and Behavioral Economics (CHIBE) invites proposals from ITMAT Members and ITMAT Associate Members in the Research Associate or Instructor A category.  It is not too late to become a Member or an Associate Member if you would like to apply for the grant and meet membership criterion.  If you are interested, please visit the membership section of our website (http://www.itmat.upenn.edu/membership.shtml) for details.

The concomitant problems of under-enrollment, selective enrollment and retention in randomized clinical trials (RCTs) often plague efforts to evaluate medical interventions. These problems often arise due to unexpected impediments to participant recruitment, which represents one of the largest costs of conducting RCTs. In recent decades, behavioral economics has provided considerable insights into how people make decisions, blending findings from economics and psychology to generate better descriptive and normative models of behavior. The goal of this pilot program is to help investigators at UPENN develop more successful strategies to increase the efficiency of clinical trial enrollment and retention across a range of different types of interventions. Please see the attached document for more information.

The proposals are due by November 3, 2017 for a proposal start date of January 1, 2018.  Please note that the instructions PDF document contains all of the documents required for submission via our Pilot Grants system.

CHIBE Enrollment 2016-2017 Awardees (pdf)

Connected Health:

Deadline: Friday, November 3, 2017 at 12pm.

The Institute for Translational Medicine and Therapeutics (ITMAT) and the LDI Center for Health Incentives and Behavioral Economics (CHIBE) invites proposals from ITMAT Members and ITMAT Associate Members in the Research Associate or Instructor A category.  It is not too late to become a Member or an Associate Member if you would like to apply for the grant and meet membership criterion.  If you are interested, please visit the membership section of our website (http://www.itmat.upenn.edu/membership.shtml) for details.

The proposal must center on novel approaches to testing and delivering interventions to improve health outcomes or health behavior for people at high risk for poor health outcomes. The purpose of this RFA is to support research teams to do quick turnaround studies focused on improving the management of population-based health within either clinical or non-clinical settings. These pilots are designed to be relatively short-term projects to create a cycle for rapid learning and iterative improvement, with a planned intervention duration for each pilot of 3-6 months.   Proposals are encouraged to use the Way to Health platform.  Way to Health is an integrated research platform that integrates information from wireless technologies, communications tools, and other applications to allow investigators to test ways of improving health behaviors and helping people keep on track to better health. Please see the attached document for more information.

The proposals are due by November 3, 2017 for a proposal start date of January 1, 2018  Please note that the instructions PDF document contains all of the documents required for submission via our Pilot Grants system.

CHIBE Connect Health 2016-2017 Awardees (pdf)


TBIC Translational Biomedical Imaging Center

 Application due date: Friday, December 8, 2017, at noon.

The Translational Biomedical Imaging Center (TBIC) was established under the leadership of the ITMAT in part "to broaden and accelerate translational imaging research through the development of a center to bring together investigators with diverse backgrounds that contribute to various aspects of imaging science and who share a vision of contributing to the advancement of clinical medicine." Among the approaches adopted by the TBIC to promote the use of imaging technology to facilitate translational research are the support of core facilities, collaborative imaging scientists, and retreats/seminars. Building on this foundation, the TBIC announces a new collaborative pilot grant program to help catalyze collaborations between primary imaging scientists and primary biomedical/clinical researchers that integrate novel imaging approaches to enhance translational science and medicine.

These proposals require at least two Co-Principal Investigators, one investigator whose primary research focus is in imaging methodology development and another investigator whose research is focused on biomedical science. At least one of the co-principal investigators should have a primary appointment in the School of Medicine. The TBIC adopts a broad definition of imaging science and seeks proposals that focus on anatomic or functional imaging approaches that span from the microscopic to in vivo regimes. Proposals that include a broad range of imaging methods including image acquisition techniques, image analysis, imaging probe development will be considered. Funding will be based on scientific merit, potential downstream clinical impact and the likelihood that the project will generate independent funding to sustain the effort. Post-pilot award outcomes will be surveyed. The deadline for applications is December 8, 2017, for an award start date of February 1, 2018.

For additional information, please visit our website or contact Drs. Mitchell Schnall at mitchell.schnall@uphs.upenn.edu,  James Gee at gee@mail.med.upenn.edu, or David Mankoff at mankoffd@mail.med.upenn.edu.

TBIC 2016-2017 Awardees (pdf)