Perelman School of Medicine at the University of Pennsylvania

Jensen Lab
Department of Neurology


Hongyu Sun, MD, PhD

Hongyu Sun, MD, PhD

Assistant professor (Research track)
PubMed Publications


Tianjin Medical University, Tianjin, P.R.China M.D. 07/97 Medicine
Tianjin Medical University, Tianjin, P.R.China M.Sc. 07/02 Neurosurgery/Neuroscience
Carleton University, Ottawa, ON, Canada Ph.D. 06/08 Neuroscience
Carleton University, Ottawa, ON, Canada Postdoc 04/09 Neuroscience
Children’s Hospital Boston, Harvard Medical School, Boston, MA Postdoc 11/12 Neurology
University of Pennsylvania, Philadelphia, PA postdoc 06/13 Neurology

Personal Statement

The goal of my research is to understand the molecular mechanisms underlying epileptogenesis in the immature brain following neonatal injury. Using extracellular and intracellular whole-cell patch clamp recording techniques, we have demonstrated that neonatal seizures enhanced AMPA receptor function an impaired synaptic plasticity in hippocampal CA1 neurons which is in part due seizure-induced decreases in silent synapses, as well as neonatal seizure-induced impaired PLK2-mediated homeostatic plasticity in CA1 neurons. We also identified an important role of mTORC1 signaling pathway in epileptogenesis following neonatal seizures in both human biopsy tissue and a mouse model. I have over 10 years of experience in electrophysiology, molecular & cellular biology and biochemistry.



Follow Us