Perelman School of Medicine at the University of Pennsylvania

Jensen Lab
Department of Neurology

Collaborators

Hongyu Sun, MD, PhD

Hongyu Sun, MD, PhD

Assistant professor (Research track)
PubMed Publications

Education/Training

Tianjin Medical University, Tianjin, P.R.China M.D. 07/97 Medicine
Tianjin Medical University, Tianjin, P.R.China M.Sc. 07/02 Neurosurgery/Neuroscience
Carleton University, Ottawa, ON, Canada Ph.D. 06/08 Neuroscience
Carleton University, Ottawa, ON, Canada Postdoc 04/09 Neuroscience
Children’s Hospital Boston, Harvard Medical School, Boston, MA Postdoc 11/12 Neurology
University of Pennsylvania, Philadelphia, PA postdoc 06/13 Neurology


Personal Statement

The goal of my research is to understand the molecular mechanisms underlying epileptogenesis in the immature brain following neonatal injury. Using extracellular and intracellular whole-cell patch clamp recording techniques, we have demonstrated that neonatal seizures enhanced AMPA receptor function an impaired synaptic plasticity in hippocampal CA1 neurons which is in part due seizure-induced decreases in silent synapses, as well as neonatal seizure-induced impaired PLK2-mediated homeostatic plasticity in CA1 neurons. We also identified an important role of mTORC1 signaling pathway in epileptogenesis following neonatal seizures in both human biopsy tissue and a mouse model. I have over 10 years of experience in electrophysiology, molecular & cellular biology and biochemistry.

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