The main theme of the June Laboratory is to apply principles of the cellular immune system to develop novel therapies for cancer
and chronic infection. We focus on the human immune system and study the biology of lymphocytes in order to manipulate their
function and development, and then apply this knowledge for potential new avenues of immunotherapy. For several years we have
been interested in the notion that various costimulatory molecules might have a role in specifying the fate of various lymphocyte
subsets. Current projects are studying the role of CD28 and TNF family members in lymphocyte function and proliferation. Other
projects involve developing advanced technology to engineer lymphocytes subsets for enhanced therapeutic effector functions.
A variety of in vitro assays and humanized mouse models are used to discover new approaches and test for potential therapeutic
activity. The June Laboratory is located in the Leonard and Madlyn Abramson Family Cancer Research Institute at the Abramson
Cancer Center at the University of Pennsylvania. Created in December 1997 with a $100 million pledge from the Abramson Family
Foundation, the Cancer Research Institute integrates research, education, and comprehensive patient care at the Abramson Cancer
Center at the University of Pennsylvania. For more information, see the Translational Research.