Kaestner Lab

School of Medicine Department of Genetics

Selected publications

Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH.
Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.
Dev Biol. 2007 Jun 15;306(2):636-45. Epub 2007 Apr 5.
PMID: 17488644 [PubMed - in process]

Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ, Kaestner KH.
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.
Genes Dev. 2007 Apr 1;21(7):756-69.
PMID: 17403778 [PubMed - indexed for MEDLINE]
Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ, Matschinsky FM, Newgard CB, Kaestner KH.
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
Mol Endocrinol. 2007 Mar;21(3):765-73. Epub 2006 Dec 21.
PMID: 17185391 [PubMed - indexed for MEDLINE]
Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH.
Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.
Diabetes. 2006 Oct;55(10):2730-6.
PMID: 17003337 [PubMed - indexed for MEDLINE]
Friedman JR, Kaestner KH.
The Foxa family of transcription factors in development and metabolism.
Cell Mol Life Sci. 2006 Oct;63(19-20):2317-28.
PMID: 16909212 [PubMed - indexed for MEDLINE]
Kaestner KH.
Of cilia and cysts: modeling pancreatic polycystic disease.
Gastroenterology. 2006 Mar;130(3):926-8.
PMID: 16530530 [PubMed - indexed for MEDLINE]
Kaestner KH.
Collecting new targets in MODY.
Cell Metab. 2005 Dec;2(6):342-4.
PMID: 16330318 [PubMed - indexed for MEDLINE]
Kaestner KH.
The making of the liver: developmental competence in foregut endoderm and induction of the hepatogenic program.
Cell Cycle. 2005 Sep;4(9):1146-8. Epub 2005 Sep 15.
PMID: 16123587 [PubMed - indexed for MEDLINE]
Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, Kaestner KH
.Glucocorticoid receptor-dependent gene regulatory networks.
PLoS Genet. 2005 Aug;1(2):e16. Epub 2005 Aug 5.
PMID: 16110340 [PubMed - indexed for MEDLINE]
Zhang L, Rubins NE, Ahima RS, Greenbaum LE, Kaestner KH
.Foxa2 integrates the transcriptional response of the hepatocyte to fasting.
Cell Metab. 2005 Aug;2(2):141-8.
PMID: 16098831 [PubMed - indexed for MEDLINE]
Rubins NE, Friedman JR, Le PP, Zhang L, Brestelli J, Kaestner KH.
Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2.
Mol Cell Biol. 2005 Aug;25(16):7069-77.
PMID: 16055718 [PubMed - indexed for MEDLINE]
Lee CS, Friedman JR, Fulmer JT, Kaestner KH. Related Articles, Links
The initiation of liver development is dependent on Foxa transcription factors.
Nature. 2005 Jun 16;435(7044):944-7.
PMID: 15959514 [PubMed - in process]
Katz JP, Perreault N, Goldstein BG, Actman L, McNally SR, Silberg DG, Furth EE, Kaestner KH.
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.
Gastroenterology. 2005 Apr;128(4):935-45.
PMID: 15825076 [PubMed - indexed for MEDLINE]
Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH.
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
J Clin Invest. 2005 Apr;115(4):1006-15. Epub 2005 Mar 3.
PMID: 15761495 [PubMed - in process]
Wan H, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA.
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
J Biol Chem. 2005 Apr 8;280(14):13809-16. Epub 2005 Jan 24.
PMID: 15668254 [PubMed - in process]
Lantz KA, Kaestner KH.
Winged-helix transcription factors and pancreatic development.
Clin Sci (Lond). 2005 Mar;108(3):195-204. Review.
PMID: 15631623 [PubMed - indexed for MEDLINE]
Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH.
Foxa2 is required for the differentiation of pancreatic alpha-cells.
Dev Biol. 2005 Feb 15;278(2):484-95.
PMID: 15680365 [PubMed - indexed for MEDLINE]
Perreault N, Sackett SD, Katz JP, Furth EE, Kaestner KH.
Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.
Genes Dev. 2005 Feb 1;19(3):311-5. Epub 2005 Jan 13.
PMID: 15650110 [PubMed - indexed for MEDLINE]

White P, Brestelli JE, Kaestner KH, Greenbaum LE.
Identification of transcriptional networks during liver regeneration.
J Biol Chem. 2005 Feb 4;280(5):3715-22. Epub 2004 Nov 16.
PMID: 15546871 [PubMed - indexed for MEDLINE]

Lee CS, Kaestner KH.
Clinical endocrinology and metabolism. Development of gut endocrine cells.
Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):453-62. Review.
PMID: 15533769 [PubMed - indexed for MEDLINE]

Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH.
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Dev Biol. 2004 Dec 1;276(1):74-88.
PMID: 15531365 [PubMed - indexed for MEDLINE]

Gupta RK, Kaestner KH.
HNF-4alpha: from MODY to late-onset type 2 diabetes.
Trends Mol Med. 2004 Nov;10(11):521-4. Review.
PMID: 15519277 [PubMed - indexed for MEDLINE]

Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang SL, Whitsett JA. Related Articles, Links
Foxa2 is required for transition to air breathing at birth.
Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14449-54. Epub 2004 Sep 27.
PMID: 15452354 [PubMed - indexed for MEDLINE]

Friedman JR, Larris B, Le PP, Peiris TH, Arsenlis A, Schug J, Tobias JW, Kaestner KH, Greenbaum LE. Related Articles, Links
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation.
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12986-91. Epub 2004 Aug 18.
PMID: 15317935 [PubMed - indexed for MEDLINE]

Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH. Related Articles, Links
Foxa2 regulates multiple pathways of insulin secretion.
J Clin Invest. 2004 Aug;114(4):512-20.
PMID: 15314688 [PubMed - indexed for MEDLINE]

Behr R, Brestelli J, Fulmer JT, Miyawaki N, Kleyman TR, Kaestner KH.
Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency.
J Biol Chem. 2004 Oct 1;279(40):41936-41. Epub 2004 Jul 13.
PMID: 15252040 [PubMed - indexed for MEDLINE]

Katz JP, Perreault N, Goldstein BG, Chao HH, Ferraris RP, Kaestner KH.
Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake.
Am J Physiol Gastrointest Liver Physiol. 2004 Oct;287(4):G856-64. Epub 2004 May 20.
PMID: 15155178 [PubMed - indexed for MEDLINE]

Wan H, Kaestner KH, Ang SL, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson PC, Rothenberg ME, Whitsett JA.
Foxa2 regulates alveolarization and goblet cell hyperplasia.
Development. 2004 Feb;131(4):953-64.
PMID: 14757645 [PubMed - indexed for MEDLINE]

Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ Jr, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Meneur C, Permutt MA.
Transcriptional program of the endocrine pancreas in mice and humans.
Diabetes. 2003 Jul;52(7):1604-10.
PMID: 12829622 [PubMed - indexed for MEDLINE]

Katz JP, Perreault N, Goldstein BG, Lee CS, Labosky PA, Yang VW, Kaestner KH.
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.
Development. 2002 Jun;129(11):2619-28.
PMID: 12015290 [PubMed - indexed for MEDLINE]

Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH.
Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice.
Gastroenterology. 2002 Mar;122(3):689-96.
PMID: 11875002 [PubMed - indexed for MEDLINE]

Perreault N, Katz JP, Sackett SD, Kaestner KH.
Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut.
J Biol Chem. 2001 Nov 16;276(46):43328-33. Epub 2001 Sep 12.
PMID: 11555641 [PubMed - indexed for MEDLINE]

Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH.
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Genes Dev. 2001 Jul 1;15(13):1706-15.
PMID: 11445544 [PubMed - indexed for MEDLINE]

Header Image:
Deletion of Foxa2 in Foxa2 ^loxP/loxP; Foxa3Cre mice. Efficiency and timing of Foxa2 deletion by Foxa3Cre were evaluated by immunofluorescence. Expression of Foxa2 was assessed by immunofluorescence in the P3 pancreas. Insulin (green) and Foxa2 (red) were found in the control pancreas (left), while Foxa2 protein was completely deleted in both islets and acini in the Foxa2 ^loxP/loxP; Foxa3Cre pancreas (right).

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