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Publications

To see more of Dr. Kahn's publications, please visit PubMed

Lymphatic function is required prenatally for lung inflation at birth. 

Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess

J Exp Med. 2014 May 5;211(5):815-26. PubMed PMID: 24733830; PubMed Central PMCID: PMC4010903.

Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.

Boulaftali Y, Hess PR, Kahn ML, Bergmeier W.

Circ Res.  2014 Mar 28;114(7):1174-84. PubMed PMID: 24677237; PubMed Central PMCID: PMC4000726.

Cerebral cavernous malformations arise independent of the heart of glass receptor.

Zheng X, Riant F, Bergametti F, Myers CD, Tang AT, Kleaveland B, Pan W, Yang

Stroke. 2014 May;45(5):1505-9. PubMed PMID: 24643410; PubMed Central PMCID: PMC4006321.

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML.

J Clin Invest. 2014 Jan 2;124(1):273-84. PubMed PMID: 24292710; PubMed Central PMCID:
PMC3871239.

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L.

Nature. 2013 Oct 3;502(7469):105-9.PubMed PMID: 23995678; PubMed Central PMCID: PMC3791160.

Platelets and tumor cells: a new form of border control.

Stanger BZ, Kahn ML.

Cancer Cell. 2013 Jul 8;24(1):9-11. PubMed PMID: 23845439; PubMed Central PMCID: PMC3743536.

The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.

Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML

J Biol Chem. 2013 Aug 23;288(34):24429-40. PubMed PMID: 23836893; PubMed Central PMCID: PMC3750143.

Lymphatics as a new active player in reverse cholesterol transport.

Kahn ML, Rader DJ.

Cell Metab. 2013 May 7;17(5):627-8. PubMed PMID: 23663731.

The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis.

Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML.

Blood. 2013 Apr 18;121(16):3228-36.PubMed PMID: 23426945; PubMed Central PMCID: PMC3655737.

Platelet ITAM signaling is critical for vascular integrity in inflammation.

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware J, Kahn ML, Bergmeier W

J Clin Invest. 2013 Feb 1;123(2):908-16. PubMed PMID: 23348738; PubMed Central PMCID:
PMC3561801.

Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.

Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didiku C, Sen A, Liu X, Skuli N, Zaslavsky A, Chen M, Cheng L, Davis GE, Kahn ML.

Dev Cell. 2012 Aug 14;23(2):342-55. PubMed PMID: 22898778; PubMed Central PMCID: PMC3743537

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ

Immunity. 2012 Aug 24;37(2):276-89. PubMed PMID: 22884313; PubMed Central PMCID: PMC3556784.

Blood flow reprograms lymphatic vessels to blood vessels.

Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML.

J Clin Invest. 2012 Jun 1;122(6):2006-17. Erratum in: J Clin Invest. 2012 Jul 2;122(7):2702. Vincente, Andres [corrected to Vicente, Andres]. PubMed PMID: 22622036; PubMed Central PMCID: PMC3366395.

 

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease.

Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML.

Blood. 2011 Sep 29;118(13):3661-9  PMID:21816834

 

High-resolution echocardiographic assessment of infarct size and cardiac function in mice with myocardial infarction.

Yuan LJ, Wang T, Kahn ML, Ferrari VA.

J Am Soc Echocardiogr. 2011 Feb;24(2):219-26. Epub 2010 Dec 30.  PMID: 21194885   

 

B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2.

Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, Reth M, Kahn ML, Schuh W, Jäck HM.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):710-5. Epub 2010 Dec 27.  PMID: 21187409

 

Platelets: covert regulators of lymphatic development.

Bertozzi CC, Hess PR, Kahn ML.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2368-71. Epub 2010 Nov 11. Review.  PMID: 21071706

 

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.

Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.

J Clin Invest. 2010 Aug;120(8):2795-804. doi: 10.1172/JCI39679. Epub 2010 Jul 1. PMID: 20592472

 

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.

Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML.

Blood. 2010 Jul 29;116(4):661-70. Epub 2010 Apr 2. PMID: 20363774

 

Jazzing up vessel growth.

Kahn ML.

Blood. 2010 Feb 25;115(8):1479.   PMID: 20185593

 

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21167-72. Epub 2009 Nov 25.  PMID: 19940238

 

Platelet integrin signaling: wherefore art thou?

Schmaier AA, Kahn ML.

Blood. 2009 Sep 24;114(13):2571-2.  PMID: 19779046

 

Negative regulation of activated alpha-2 integrins during thrombopoiesis.

Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML.

Blood. 2009 Jun 18;113(25):6428-39. Epub 2009 Mar 3.

 

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway.  Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Chen M, Guo L, Zhou D, Kitajewski J, Affolter M, Ginsberg MH, Kahn ML. 

Nature Medicine. 2009 Feb;15(2):169-76.

 

Klf2 regulates naive T cell migration by restricting chemokine receptor expression patterns.  Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML.

Nature Immunology.  2008 9(3):292-300.

 

Klf2 is an essential regulator of vascular hemodynamic forces in vivo.  Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML.

Developmental Cell.  2006 Dec.11 (6):845-57.

 

Syk and Slp-76 mutant mice reveal a cell autonomous hematopoietic cell contribution to vascular development.  Sebzda E, Hibbard C, Sweeney S, Abtahian F, Bezman N, Clemens G, Maltzman J, Cheng L, Zhou D, Turner M, Tybulewicz V, Koretzky GA, Kahn ML.

Developmental Cell.  2006 Sep; 11(3):349-61.

 

In vivo integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. 

Chen H, Zou Z, Sarratt KL, Zhou D, Lu MM, Hammer DA, Kahn ML. 

Genes and Development.  2006  Apr 15;20(8):927-32.

 

GPVI and a2b1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow.

Sarratt, KL, Chen, H, Zutter, MM, Santoro, SA, Hammer, DA, Kahn, ML

Blood.  2005  Aug 15;106(4):1268-77.

 

Regulation of blood lymphatic vascular separation by signaling proteins SLP-76 and Syk.  Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsia A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Joretzky GA, Kahn ML

Science.  299 (5604): 247-251.