Edward N. Pugh's Lab
Recent Publications
Lyubarsky, A. L. and Pugh, Jr., E. N. (1996) The recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings. Journal of Neuroscience, 16(2), 563-571. (abstract)
Nikonov, S., Lyubarsky, A. and Pugh, Jr., E.N. (1996) The kinetics of inactivation of the rod phototransduction cascade with constant Ca2+i. Journal of General Physiology, 107, 19-34. (abstract)
Tyo, J.S., Rowe, M.P., Pugh, Jr., E.N. and Engheta, N. (1996) Target detection in optically scattering media using polarization-difference imaging. Applied Optics, 35, 1855-1870.
Rowe, M.P., Corless, J.M., Engheta, N. and Pugh, Jr., E.N. (1996) Scanning interferometry of sunfish cones. I. Longitudinal variation in single-cone refractive index. Journal of the Optical Society of America A, 13, 2141-2150.
Cideciyan, A.V., Pugh, Jr., E.N., Lamb, T.D., Huang, Y. and Jacobson, S.G. (1997) Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and Vitamin A deficiency. Investigative Ophthalmology and Visual Science, 38, 1786-1794.
Pugh, Jr., E.N., Duda, T., Sitaramayya, A. and Sharma, R. (1997) Photoreceptor guanylate cyclases: a review. Bioscience Reports, 17, 429-474.
Nikonov, S., Engheta, N. and Pugh, Jr., E.N. (1998) The kinetics of recovery of the dark adapted salamander rod photoresponse. Journal of General Physiology. 111, 7-38. (pdf reprint)
Tyo, S., Pugh, Jr., E.N. and Engheta, N. (1998) Colorimetric representations for use with polarization-difference imaging of objects in scattering media. Journal of the Optical Society of America A, 15(2):367-374.
Pennesi, M.E , Lyubarsky, A.L. and Pugh, Jr., E.N. (1998) Extreme responsiveness of the pupil of the dark-adapted mouse to steady retinal illumination. Investigative Ophthalmology and Visual Science, 11, 2148-2156.
Pugh, Jr., E.N., Falsini, B. and Lyubarsky, A.L. (1998) The origin of the major rod- and cone-driven components of the rodent electroretinogram, and the effect of age and light-rearing history on the magnitudes of these components. In T.P. Williams and A.B. Thistle (Eds.), Photostasis and Related Topics, pp. 93-128. New York: Plenum. (pdf, 9.1 Mb)
Lyubarsky, A.L., Falsini, B., Pennesi, M.E, Valentini, P. and Pugh, Jr., E.N. (1999) UV- and Midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for co-expression of cone photopigments. Journal of Neuroscience 19(1), 1-14. (pdf reprint)
Pugh, Jr., E.N., Nikonov, S. and Lamb, T.D. (1999) Molecular mechanisms of vertebrate photoreceptor light adaptation. Current Opinion in Neurobiology, 9, 410-418. (html reprint)
Lyubarsky, A.L., Chen, C.-K., Simon, M.I. and Pugh, Jr., E.N. (2000) Mice lacking G-protein receptor kinase 1 (GRK1) have profoundly slowed recovery of cone-driven retinal responses. Journal of Neuroscience, 20(6), 2209-2217. (pdf reprint)
Pugh, E.N., Jr. and Lamb, T.D. (2000) Phototransduction in Vertebrate Rods and Cones: Molecular Mechanisms of Amplification, Recovery and Light Adaptation. Chapter 5, in D.G. Stavenga, W.J. de Grip and E.N.Pugh, Jr. (eds), Handbook of Biological Physics, Vol. 3, pp. 183-254. Elsevier: Amsterdam. (pdf, 1.6 Mb)
Leskov, I.B., Klenchin, V.A., Handy, J.W., Whitlock, G.G., Govardovskii, V.I., Bownds, M.D., Lamb, T.D., Pugh, Jr., E.N. and Arshavsky, V.Y. (2000) The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements. Neuron, 27, 525-537. (pdf, 0.5 Mb)
Nikonov, S.S., Lamb, T.D. and Pugh, Jr., E.N. (2000) The role of steady phosphodiesterase activity in the kinetics and sensitivity of the light-adapted salamander rod photoresponse. Journal of General Physiology, 116, 795-824. (pdf reprint)
Calvert, P.D., Krasnoperova, N.V., Lyubarsky, A.L., Isayama, T., Nicolo, M., Kosaras, B., Wong, G., Gannon, K.S., Margolskee, R.F., Sidman, R.L., Pugh, Jr., E.N., Makino, C.L., Lem, J. (2000) Phototransduction in transgenic mice after targeted deletion of the rod transducin a-subunit. Proceedings of the National Academy of Sciences, 97, 13913-13918. (pdf, 0.2 Mb)
Dhingra, A., Lyubarsky, A.L., Jiang, M., Pugh, Jr., E.N., Birnbaumer, L., Sterling, P. and Vardi, N. (2000) The light responses of ON-bipolar neurons require Gao. Journal of Neuroscience, 20(24), 9053-9058. (pdf reprint)
Lyubarsky, A.L., Chen, C.-K., Naarendorp, F., Zhang, X, Wensel, T., Simon, M.I., and Pugh, Jr., E.N. (2001) RGS9-1 is required for normal inactivation of mouse cone phototransduction. Molecular Vision, 7, 71-78.
Rattner, A., Smallwood, P.M., Williams, J., Cooke C., Lyubarsky, A.L, Savchenko, A., Pugh, Jr., E.N. and Nathans, J. (2001) A novel photoreceptor-specific cadherin is essential to the structural integrity of the outer segment and for photoreceptor survival. Neuron, 32, 775-786. (pdf, 0.4 Mb)
Arshavsky, V.Y., Lamb, T.D. and Pugh, Jr., E.N. (2002) G Proteins and Phototransduction. Annual Review of Physiology, 64, 153-187. (pdf, 0.7 Mb)
Lyubarsky, A.L., Lem, J., Chen, J., Falsini, B., Iannaconne and Pugh, Jr., E.N. (2001) Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. Vision Research, 42, 401-415.
Sokolov, M., Lyubarsky, A.L, Strissel, K.J., Savchenko, A., Govardovskii, V.I. Pugh, Jr., E.N. and Arshavsky, V.Y. (2002). Massive light-dependent translocation of transducin between the functional compartments of rod photoreceptors: a novel mechanism of light adaptation. Neuron, 33, 95-106. (pdf, 4.5 Mb)