Dr. Bajaj joined Laboratory of Applied PK/PD as a Postdoctoral Fellow in 2011, and possess strong background in Pharmacy and Pharmacological research. He received his bachelor degree in Pharmacy and Master in Pharmacology from Delhi Institute of Pharmaceutical Sciences in India. Later, he graduated from Oregon State University with a Ph.D. in Pharmacology focusing on regulation of NMDA receptors and MDR1 in the brain. He studied the role of a protein called CTIP2 in skin cancer and wound healing in a cancer signaling lab in Oregon as well. During his Ph.D. program, he worked as a summer intern at Merck on evaluation of in vitro permeability of new drug candidates. Prior to joining CHOP, he worked on a research project funded by National Cancer Institute in the Laboratory of Therapeutic Particle Engineering at Purdue University. His research was focused on developing animal models of ovarian cancer, evaluating the effectiveness of new nanocarriers and hydrogels after intraperitoneal administration for local therapy of ovarian cancer. His contribution to the research was awarded through a number of publications, Society of Neuroscience Oregon Chapter Neuron award, travel awards from American Association of Pharmaceutical Scientist and Oregon State University. Dr. Bajaj is developing a disease progression model in cancer, utilizing model based approach to study PK/PD, drug-drug interaction and performing clinical trial simulation to design trials and experiments.
Bajaj G , Yeo Y. Drug delivery systems for intraperitoneal therapy. Pharmaceutical Research , 2010 May; 27(5): 735-8
Wang Z, Coleman D, Bajaj G , Liang X, Indra G and Indra AK. RXRa ablation in epidermal keratinocytes results in enhanced UV radiation induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes Journal of Investigative Dermatology , 2011 Jan; 131(1):177-87.
Xu P, Bajaj G , Shugg T, Van Alstine WG, Yeo Y. Zwitterionic chitosan derivatives for pH-sensitive stealth coating Biomacromolecules , 2010 Sep 13;11(9):2352-8).
Hyter S, Bajaj G , Liang X, Barbacid M, Indra G and Indra AK. Loss of nuclear receptor RXRa in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas Pigment Cell and Melanoma Research , 2010 Oct 23(5):635-48.
Bajaj G , Rodriguez-Proteau R, Venkataraman A, Fan Y, Kioussi C, Ishmael JE. MDR1 function is sensitive to the phosphorylation state of Myosin regulatory light chain. Biochemical and Biophysical Research Communication , 2010 Jul 16; 398(1):7-12.
Bajaj G , Young Z, Schimerlik MI, Hau AM, Yang J, Filtz TM, Kioussi C, Ishmael, JE. NMDA receptor subunits: Non-myosin targets of myosin regulatory light chain interaction. Journal of Biological Chemistry , 2009 Jan 9; 284(2):1252-66
Kioussi C, Appu M, Löhr C, Fischer K, Bajaj G , Leid M, Ishmael JE. Co-expression of myosin II regulatory light chain and the NMDAR1 subunit in neonatal and adult mouse brain. Brain Research Bulletin, 2007, Nov 1; 74(6): 439-51.
Amparan D, Avram D, Thomas CG, Lindahl MG, Yang J, Bajaj G , and Ishmael JE. Direct interaction of myosin regulatory light chain with NMDA receptor. Journal of Neurochemistry, 2005, 92(2), 349-61.