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Jeffrey S. Barrett, Ph.D., FCP
Research Associate Professor, Pediatrics
Director, Pediatric Pharmacology Research Unit,
Laboratory for Applied PK/PD
Clinical Pharmacology & Therapeutics
Abramson Research Center, Rm 916H
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Jeffrey S. Barrett, PhD, Research Associate Professor of pediatrics will direct the PKMS core overseeing all aspects of the core operations. Dr. Barrett is currently the Director of the Laboratory for Applied PK/PD within the Division of Clinical Pharmacology of The Children's Hospital of Philadelphia . He is also the Principal Investigator of the CHOP Pediatric Pharmacology Research Unit (PPRU), one of 13 units established units throughout the U.S. by the National Institute of Child Health and Human Development and is supported by a U01 grant. The CHOP has been a PPRU site since 1998 and has participated in a multitude of industry sponsored pediatric clinical research directed at improving pediatric drug labeling, and has developed and performed a number of investigator initiated and grant-supported pediatric clinical pharmacology studies. The strength of the CHOP PPRU site has been bioanalytical laboratory and the modeling and simulation capabilities.
Dr. Barrett will lead this unit and provide support to all CTSA projects in which modeling and simulation strategies can advance decision making and facilitate informative experimentation/investogation. Dr. Barrett was recruited to CHOP to build a modeling and simulation center of excellence within the Clinical Pharmacology & Therapeutics Division. Under these auspices, he directs the Laboratory for Applied PK/PD emphasizing model-based approaches to translational research. Subsequently, Dr. Barrett has secured funding from the pharmaceutical industry (Glaxo SmithKline and Pfizer) to train post-doctoral candidates (Drs Manish Gupta and Divya Menon) in pharmacometrics and is mentoring several clinical investigators (Drs Athena Zuppa, Jeffrey Skolnik, Felice Su and Kelly Wade) seeking to learn these techniques with application to pediatric subpopulations (critically-ill children, neonates, and children with cancer). Likewise, modeling and simulation has been integrated into a number of funded (NIH and industry) research programs. The modeling and simulation unit will draw from existing expertise in the Penn-CHOP community defined by the CTSA as well as external collaborators who support these efforts (see pharmacometrics training unit).