Kinetic Modeling and Simulation ( KMAS ) core will provide crucial infrastructure to the growing translational effort at the partner institutions of the University of Pennsylvania and Children's Hospital of Philadelphia Clinical & Translational Science Award (CTSA). Jeffrey S. Barrett, Ph.D. of CHOP will direct the core. The core will (a) aid in the development of drug assays; (b) promote and assist in the performance of tracer kinetic studies; (c) develop novel approaches to kinetic data analysis; (d) provide pharmacokinetic (PK), PK– pharmacodynamic (PD), and tracer kinetic modeling; and (e) develop educational modules in pharmacokinetics and tracer kinetics to populate the educational initiatives pursued within the CTSA.
Mission
The Kinetic Modeling and Simulation (KMAS) Core supports members of the Penn/CHOP CTSA through the planning of experimental designs and clinical investigations as well as the quantitative analysis of such investigations via model-based approaches. A variety of methodologies and techniques are utilized in these endeavors including response surface modeling to aid the construction of efficient dose-response experiments in vitro, nonlinear least squares and moment-based noncompartmental analysis for richly sampled PK and PK/PD analyses, nonlinear mixed-effect modeling and nonparametric analysis (nonparametric EM algorithm) for sparsely sampled, population-based, PK and PK/PD designs, Monte Carlo simulation and Markov Chain Monte Carlo (MCMC) simulation for clinical trial simulation. A variety of algorithms are used to support these efforts (NONMEM, SAS, R, NPEM, WinBUGS, WinNonlin, Trial Simulator) as well as home grown algorithms for specific projects (e.g., discrete event simulation).
Upcoming Workshops |
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