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News and Annoucments
Our thanks for the NIH for supporting our high-risk, high-reward ideas via an NIH Director's New Innovator Award!
The Edward Mallinckrodt, Jr. Foundation names Rahul as the 54th Mallinckrodt Scholar
See our work on the role of deaminases in DNA demethylation in Nature Chemical Biology, July 2012
Our thanks to the Doris Duke Foundation for awarding Rahul the Clinical Scientist Development Award!
Congratulations to Chris Nabel for the best poster award at the BMB Retreat, June 2012.
Best wishes to Laura Wang as she heads to Columbia Teacher's College!
Check out our review on cytosine as the genomic "wild card" (Jan 2012) in ACS Chemical Biology!
See our Perpective on DNA demethylation in Science (Sept 2011)
Our thanks to the Rita Allen Foundation for naming Rahul as a Rita Allen Scholar, June 2011
Congratulations to Charlie Mo for selection to the Cell and Molecular Biology Training Grant!
A warm welcome to our second lab baby, Charak Kohli, born June 17, 2011!
Welcome to Charlie Mo and Chris Nabel who have joined lab for their PhD thesis work
Our thanks to TriLink for supporting our lab's research through their Research Rewards Grant
Congratulation to Kiran Gajula on welcoming his first child, Joel Gajula, on March 9, 2011!
Check out our award winning "Grand Challenges" essay in Nature Chemical Biology, December 2010!
Welcome to the Kohli Lab!
While we conventionally think of genomic DNA as a simple polymer of A's, C's, G's, and T's, the chemistry of the genome is in fact far more interesting.
Our laboratory focuses on the DNA modifying enzymes that provide an added layer of complexity to the genome. These enzymes can be involved in the purposeful introduction of mutations or in the chemical modification of nucleobases, making DNA into a remarkably dynamic entity. Many of these processes are at the heart of the battle between the immune system and pathogens.
We utilize a broad array of approaches, which include 1) biochemical characterization of enzyme mechanisms, 2) chemical synthesis of enzyme probes, and 3) biological assays spanning bacteriology, immunology, and virology to study DNA modifying enzymes.
Our research program aims to understand, harness and perturb there diversity generating pathways.
• Last updated: 02/17/2014