Perelman School of Medicine at the University of Pennsylvania

Kohli Lab

Division of Infectious Diseases, Department of Medicine
Department of Biochemistry & Biophysics

Photos taken by: name of photograhper

News and Annoucments

Our thanks for the NIH for supporting our high-risk, high-reward ideas via an NIH Director's New Innovator Award!

The Edward Mallinckrodt, Jr. Foundation names Rahul as the 54th Mallinckrodt Scholar

See our work on the role of deaminases in DNA demethylation in Nature Chemical Biology, July 2012

Our thanks to the Doris Duke Foundation for awarding Rahul the Clinical Scientist Development Award!

Congratulations to Chris Nabel for the best poster award at the BMB Retreat, June 2012.

Best wishes to Laura Wang as she heads to Columbia Teacher's College!

Check out our review on cytosine as the genomic "wild card" (Jan 2012) in ACS Chemical Biology!

See our Perpective on DNA demethylation in Science (Sept 2011)

Our thanks to the Rita Allen Foundation for naming Rahul as a Rita Allen Scholar, June 2011

Congratulations to Charlie Mo for selection to the Cell and Molecular Biology Training Grant!

A warm welcome to our second lab baby, Charak Kohli, born June 17, 2011!

Welcome to Charlie Mo and Chris Nabel who have joined lab for their PhD thesis work

Our thanks to TriLink for supporting our lab's research through their Research Rewards Grant

Congratulation to Kiran Gajula on welcoming his first child, Joel Gajula, on March 9, 2011!

Check out our award winning "Grand Challenges" essay in Nature Chemical Biology, December 2010!

Research Areas

1. Origins and implications of immunologic diversity

Purposeful modificationof cytosine provides a key weapon used by both the adaptive and innate arms of the immune system. DNA modifying enzymes also have potential roles beyond immune defense, in processes such as DNA demethylation.

Fig RA 1

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2. Targeting pathogen diversity-generating enzymes

Pathogens make use of programmed pathways to alter themselves to evade immune responses or the antimicrobials. These diversity generating pathways are a potential novel antimicrobial target.

 

Fig RA 3

• Last updated: 11/09/2012