Perelman School of Medicine at the University of Pennsylvania
Kolson Lab
Recent Publications
Selected Publications

Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity; a novel candidate for HIV-neuroprotection.
Cross SA, Cook DR, Chi AWS, Vance PJ, Kolson LL, Wong BJ, Jordan-Sciutto KL, Kolson DL. 2011.
J. Immunol. 2011 Dec;187(10): pp-pp. [Link]

NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury.
Cook DR, Gleichman AJ, Cross SA, Doshi S, Ho W, Jordan-Sciutto KL, Lynch DR, Kolson DL.
J Neurochem. 2011 Sep;118(6):1113-23. [Link]

Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.
O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL.
J Neurosci. 2006 Jan 18;26(3):981-90. [Link]

Current understanding of HIV-associated neurocognitive disorders pathogenesis.
Gannon P, Khan MZ, Kolson DL.
Curr Opin Neurol. 2011 Jun;24(3):275-83. Review. [Link]

2010-2011

NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury.
Cook DR, Gleichman AJ, Cross SA, Doshi S, Ho W, Jordan-Sciutto KL, Lynch DR, Kolson DL.
J Neurochem. 2011 Sep;118(6):1113-23.

Activation status of integrated stress response pathways in neurons and astrocytes of HAND cortex.
Akay C, Lindl K, Shyam N, Nabet B, Goenaga-Vazquez Y, Ruzbarsky J, Wang Y, Kolson DL, Jordan-Sciutto KL.
Neuropathol Appl Neurobiol. 2011 Aug 22.

Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity.
Akay C, Lindl KA, Wang Y, White MG, Isaacman-Beck J, Kolson DL, Jordan-Sciutto KL.
Mol Cell Neurosci. 2011 Jun;47(2):154-65. Epub 2011 Apr 12.

Current understanding of HIV-associated neurocognitive disorders pathogenesis.
Gannon P, Khan MZ, Kolson DL.
Curr Opin Neurol. 2011 Jun;24(3):275-83. Review.

Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
Li J, Ye L, Cook DR, Wang X, Liu J, Kolson DL, Persidsky Y, Ho WZ.
J Neuroinflammation. 2011 Feb 15;8:15.

Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration.
White MG, Wang Y, Akay C, Lindl KA, Kolson DL, Jordan-Sciutto KL.
Neurosci Res. 2011 Jun;70(2):220-9. Epub 2011 Feb 1.

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment.
Li L, Aiamkitsumrit B, Pirrone V, Nonnemacher MR, Wojno A, Passic S, Flaig K, Kilareski E, Blakey B, Ku J, Parikh N, Shah R, Martin-Garcia J, Moldover B, Servance L, Downie D, Lewis S, Jacobson JM, Kolson D, Wigdahl B.
J Neurovirol. 2011 Feb;17(1):92-109. Epub 2011 Jan 12.

Human immunodeficiency virus-associated distal sensory polyneuropathy: still common after many successes.
Kolson DL, González-Scarano F.
Arch Neurol. 2010 May;67(5):534-5.

Memantine for AIDS dementia complex: open-label report of ACTG 301.
Zhao Y, Navia BA, Marra CM, Singer EJ, Chang L, Berger J, Ellis RJ, Kolson DL, Simpson D, Miller EN, Lipton SA, Evans SR, Schifitto G; Adult Aids Clinical Trial Group (ACTG) 301 Team.
HIV Clin Trials. 2010 Jan-Feb;11(1):59-67.

HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities.
Lindl KA, Marks DR, Kolson DL, Jordan-Sciutto KL.
J Neuroimmune Pharmacol. 2010 Sep;5(3):294-309. Epub 2010 Apr 16. Review.

HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment.
Gupta RG, Kelly KM, Helke KL, Queen SE, Karper JM, Dorsey JL, Brice AK, Adams RJ, Tarwater PM, Kolson DL, Mankowski JL.
Am J Pathol. 2010 Jun;176(6):2776-84. Epub 2010 Apr 9.

2008-2009

Propionibacterium acnes brain abscess appearing 10 years after neurosurgery.
Kranick SM, Vinnard C, Kolson DL.
Arch Neurol. 2009 Jun;66(6):793-5.

Expression and regulation of antiviral protein APOBEC3G in human neuronal cells.
Wang YJ, Wang X, Zhang H, Zhou L, Liu S, Kolson DL, Song L, Ye L, Ho WZ.
J Neuroimmunol. 2009 Jan 3;206(1-2):14-21. Epub 2008 Nov 21.

Combination antiretroviral therapy modulates the blood oxygen level-dependent amplitude in human immunodeficiency virus-seropositive patients.
Ances BM, Roc AC, Korczykowski M, Wolf RL, Kolson DL.
J Neurovirol. 2008 Oct;14(5):418-24.

YKL-40: a candidate biomarker for simian immunodeficiency virus and human immunodeficiency virus encephalitis?
Kolson DL.
Am J Pathol. 2008 Jul;173(1):25-9. Review.

Frontal encephalocele in a middle-aged woman with first seizure: smells like a seizure to me.
Morley JF, Kolson DL.
Neurology. 2008 Jan 8;70(2):157. No abstract available.

2006-2007

Neurological function and HIV risk behaviors of female prison inmates.
Brewer-Smyth K, Bucurescu G, Shults J, Metzger D, Sacktor N, van Gorp W, Kolson D.
J Neurosci Nurs. 2007 Dec;39(6):361-72.

Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.
Wang Y, White MG, Akay C, Chodroff RA, Robinson J, Lindl KA, Dichter MA, Qian Y, Mao Z, Kolson DL, Jordan-Sciutto KL.
J Neurochem. 2007 Oct;103(2):439-55.

Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury.
O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR, Kolson DL.
J Neurochem. 2007 Sep;102(6):1905-17.

A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment.
Schifitto G, Zhang J, Evans SR, Sacktor N, Simpson D, Millar LL, Hung VL, Miller EN, Smith E, Ellis RJ, Valcour V, Singer E, Marra CM, Kolson D, Weihe J, Remmel R, Katzenstein D, Clifford DB; ACTG A5090 Team.
Neurology. 2007 Sep 25;69(13):1314-21. Epub 2007 Jul 25.

Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study.
Schifitto G, Navia BA, Yiannoutsos CT, Marra CM, Chang L, Ernst T, Jarvik JG, Miller EN, Singer EJ, Ellis RJ, Kolson DL, Simpson D, Nath A, Berger J, Shriver SL, Millar LL, Colquhoun D, Lenkinski R, Gonzalez RG, Lipton SA; Adult AIDS Clinical Trial Group (ACTG) 301; 700 Teams; HIV MRS Consortium.
AIDS. 2007 Sep 12;21(14):1877-86.

Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
Roc AC, Ances BM, Chawla S, Korczykowski M, Wolf RL, Kolson DL, Detre JA, Poptani H.
Arch Neurol. 2007 Sep;64(9):1249-57. Epub 2007 Jul 9.

Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration.
Markowitz AJ, White MG, Kolson DL, Jordan-Sciutto KL.
Cellscience. 2007 Jul 27;4(1):111-146.

Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.
Paul RH, Yiannoutsos CT, Miller EN, Chang L, Marra CM, Schifitto G, Ernst T, Singer E, Richards T, Jarvik GJ, Price R, Meyerhoff DJ, Kolson D, Ellis RJ, Gonzalez G, Lenkinski RE, Cohen RA, Navia BA.
J Neuropsychiatry Clin Neurosci. 2007 Summer;19(3):283-92.

Morphine upregulates functional expression of neurokinin-1 receptor in neurons.
Wan Q, Douglas SD, Wang X, Kolson DL, O'Donnell LA, Ho WZ.
J Neurosci Res. 2006 Nov 15;84(7):1588-96.

A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy.
Schifitto G, Yiannoutsos CT, Simpson DM, Marra CM, Singer EJ, Kolson DL, Nath A, Berger JR, Navia B; Adult AIDS Clinical Trials Group (ACTG) 301 tEAM.
J Neurovirol. 2006 Aug;12(4):328-31.

Caudate blood flow and volume are reduced in HIV+ neurocognitively impaired patients.
Ances BM, Roc AC, Wang J, Korczykowski M, Okawa J, Stern J, Kim J, Wolf R, Lawler K, Kolson DL, Detre JA.
Neurology. 2006 Mar 28;66(6):862-6.

CXCL10-induced cell death in neurons: role of calcium dysregulation.
Sui Y, Stehno-Bittel L, Li S, Loganathan R, Dhillon NK, Pinson D, Nath A, Kolson D, Narayan O, Buch S.
Eur J Neurosci. 2006 Feb;23(4):957-64.

Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.
O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL.
J Neurosci. 2006 Jan 18;26(3):981-90.

Older Publications

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