Lamitina Lab
Integrative analysis of environmental stress signaling in C. elegans
All organisms are constantly challenged by stressful environmental conditions, and these conditions play major roles in infleuncing the etiology of many human diseases. The Lamitina lab is interested in deciphering the signaling pathways that sense and respond to environmental stress using integrative approaches in the nematode C. elegans. By exploiting the genetic, genomic, and biochemical advantages of this system, we hope to gain better insights into how animals engage the environment and to better define the roles of environmental stress signaling pathways in disease pathogenesis. Currently, we are using this system to define the molecular mechanisms underlying the response to osmotic stress and to understand how osmotic stress signaling pathways infleuence diseases of protein misfolding.