Model organisms, such as the nematode C. elegans, have generated major insights into mechanisms of human physiology and disease. In the Lamitina Lab, we use the power of C. elegans genetics to address two major physiological questions:
- How do multicellular animals sense, respond, and discriminate between different proteotoxic stressors?
- What are the molecular mechanisms underlying the organization and maintenance of the neuromuscular junction?
To address these questions, we employ high-throughput RNAi screening, in vivo imaging, mathematical modeling, and electrophysiological methods. Ultimately, our studies seek to leverage the tremendous experimental advantages of C. elegans to gain deeper physiological insights into processes and diseases affecting humans.