LAB MEMBERS

Mark A. Lemmon, Ph.D.
George W. Raiziss Professor of Biochemistry and Biophysics
Chair, Department of Biochemistry and Biophysics

B.A. University of Oxford (1988)
M. Phil. Yale University (1990)
Ph.D. Yale University (1993)

mlemmon@mail.med

Administrative Staff

Pamela Burgess-Jones, Lab Manager
pbjones@mail.med

Patti Thorp, M.A. Executive Assistant
thorp@mail.med
215-898-1876

Research Associate

Jeannine Mendrola, Ph.D., Research Associate

mendrola@yahoo

American Cancer Society Howard and Jean Grossman Postdoctoral Fellowship
University of Pennsylvania (2000 – 2003), Advisor: Dr. Mark A. Lemmon
Project: Transmembrane Domains in ErbB Receptor Activation
PhD, Genetics, Thomas Jefferson University (1998) Advisor: Dr. Kay Huebner
Thesis Project: The Role of Protein Tyrosine Phosphatase g (Ptpg ) in Development
B.A. Biochemistry, University of Pennsylvania (1990)

Research Interest: Currently I am interested in elucidating the mechanism of activation of the Ror2 family of receptor tyrosine kinases in non-canonical Wnt signaling emphasizing structure-function relationships.

Jason Moore, Ph.D., Postdoctoral Researcher

Ph.D. 2009, Biochemistry and Molecular Biophysics, Columbia University
M.Phil. 2003, Biochemistry and Molecular Biophysics, Columbia University
M.S. 2001, Biochemistry and Molecular Biophysics, Columbia University
B.S. 2000, Biology, Pennsylvania State University

jamoore@mail.med

Research Interest: My research is focused on the structural basis of signaling in receptor tyrosine kinases that contain extracellular FNIII domains. Using a variety of tools, from biophysical methods to cellular studies, my goal is to determine whether these FNIII domains have a uniform role in mediating receptor dimerization and activation. My graduate work was performed in Wayne Hendrickson's lab at Columbia University where I studied signaling in the TorT-TorS-TorR bacterial two-component system.

Camilla L. Oxley, Ph.D., Postdoctoral Researcher

Bachelor of Engineering in Chemistry, Reutlingen University, Germany (2005).

D.Phil., Biochemistry, University of Oxford, U.K. (2010).
Recipient of a Wellcome Trust Ph.D. Fellowship (2005-2009)
Advisors: Prof. Jane Endicott and Prof. Iain Campbell
Research Title: Posttranslational modifications in integrin signaling and proteasome targeting

oxley@mail.med

Research Interest: Currently I am interested in the mechanistic basis of EGFR and ALK inhibition. Overall, my approach is to combine cell-signalling techniques with structural studies to understand the molecular architecture, recognition, and regulation of these receptor tyrosine kinases.

Stephen Artim, V.M.D.-Ph.D. student

Graduate Group: Biochemistry and Molecular Biophysics
B.S. 2004, Haverford College (Biology/Biochemistry)

sartim@vet

Research Interest: I am using structural and biochemical techniques to study the tyrosine kinase domains of the Trk family of receptor tyrosine kinases. The Trk receptors have been implicated in various diseases and understanding the mechanism of autoinhibition and activation will likely benefit the design of specific inhibitors.

Nicholas Bessman, Graduate Student

Graduate group: Biochemistry/Molecular Biophysics
B.S., 2006 Iowa State University (Biochemistry)

nichj@mail.med

Research Interest: The EGF receptor is an important drug target in several cancers, and a key 'model system' in cellular-signal transduction. My goal is to use biophysical, biochemical, and structural approaches to better understand how the ligand stimulates EGF receptor signaling, with an eye towards improved therapeutics, and a fundamental understanding of how extracellular signals are transmitted across the cell membrane.

Jin H. Park, Graduate student

Graduate group: Department of Biochemistry and Biophysics
B.A. (2006) Molecular and Cell Biology, University of California, Berkeley

Postbaccalaureate Intramural Research Training Award, National Institute of Health, Bethesda, M.D. (2007-2008)

jinhpark@mail.med

Research Interest: I am currently interested in understanding the regulation of EGFR, ALK and CCK4 kinases and how these RTKs (receptor tyrosine kinases) mediate cellular signaling based on biochemical, binding and structural studies with cell-based assays.

Kelsey Speer, Graduate Student

Graduate group: Cell and Molecular Biology
Undergraduate School: Macalester College

kspeer@mail.med

Research Interest: I spent one year working as a trainee at the National Institutes of Health in Bethesda, Maryland before joining the Lemmon lab in 2012. My current interests include the role of non-canonical receptor tyrosine kinases in Wnt signaling, with an emphasis on in vivo modeling using Xenopus laevis. My thesis project is being co-mentored by Dr. Peter Klein.

Neo Zhengyi Wu, Graduate Student

Graduate group: Biochemistry/Molecular Biophysics
B.S., Chemistry, Nanjing U. (2007)
M.S., Inorganic Biological Chemistry, Nanjing U. (2009)

zhengyi@mail.med

Research Interest: I am interested in understanding cell signaling at molecular and systems levels and developing potential cancer therapeutics. I am also very interested in developing novel computational algorithms to model and learn biological systems.