LAB MEMBERS

Mark Lemmon

Mark A. Lemmon, Ph.D.
George W. Raiziss Professor of Biochemistry and Biophysics
Chair, Department of Biochemistry and Biophysics

B.A., 1988, University of Oxford
M. Phil., 1990, Yale University
Ph.D., 1993, Yale University

mlemmon@mail.med.upenn.edu

 

Administrative Staff

Pam Burgess-Jones

Pamela Burgess-Jones, Lab Manager

B.A., 1995, Biology, Cheyney University

pbjones@mail.med.upenn.edu
215-898-3411

Patti Thorp

Patti Thorp, M.A. Executive Assistant

B.A., 1989, Linguistics, Pennsylvania State University
M.A., 1994, Linguistics, University of Pennsylvania

thorp@mail.med.upenn.edu
215-898-1876

Research Associate

Jeannine Mendrola

Jeannine Mendrola, Ph.D., Research Associate

B.A., 1990, Biochemistry, University of Pennsylvania
PhD, 1998, Genetics, Thomas Jefferson University

mendrola @ yahoo.com

Research Interest: Currently I am interested in elucidating the mechanism of activation of the Ror2 family of receptor tyrosine kinases in non-canonical Wnt signaling emphasizing structure-function relationships.

Postdoctoral Researchers

Dan Freed, Ph.D. Postdoctoral Fellow

NIH Ruth L. Kirschstein NRSA F32 Fellowship

B.S., 2006, Chemistry, University of North Carolina Wilmington
Ph.D., 2012, Chemistry, University of Virginia

danfreed @ mail.med.upenn.edu

Research Interest: I am interested in understanding the structural basis of transmembrane signaling by the EGF receptor. Although the EGFR is one of the most well-studied proteins, the allosteric mechanisms by which different regions of the receptor communicate remain poorly understood. Towards this end, I am combining techniques in structural biology, biophysics and biochemistry to examine conformational changes associated with the activation of intact receptor dimers reconstituted into a physiologically-relevant membrane context.

 

Jason Moore

Jason Moore, Ph.D., Postdoctoral Fellow

American Cancer Society Fellowship

B.S., 2000, Biology, Pennsylvania State University
M.S., 2001, Biochemistry and Molecular Biophysics, Columbia University
M.Phil., 2003, Biochemistry and Molecular Biophysics, Columbia University
Ph.D., 2009, Biochemistry and Molecular Biophysics, Columbia University

jamoore @ mail.med.upenn.edu

Research Interest: My research is focused on the structural basis of signaling in receptor tyrosine kinases that contain extracellular FNIII domains. Using a variety of tools, from biophysical methods to cellular studies, my goal is to determine whether these FNIII domains have a uniform role in mediating receptor dimerization and activation. My graduate work was performed in Wayne Hendrickson's lab at Columbia University where I studied signaling in the TorT-TorS-TorR bacterial two-component system.

 

Camilla L. Oxley, D.Phil., Postdoctoral Fellow

American Association for Cancer Research Fellowship

B.Eng., 2005, Chemistry, Reutlingen University
D.Phil., 2010, Biochemistry, University of Oxford

oxley @ mail.med.upenn.edu

Research Interest: Currently I am interested in the mechanistic basis of EGFR and ALK inhibition. Overall, my approach is to combine cell-signalling techniques with structural studies to understand the molecular architecture, recognition, and regulation of these receptor tyrosine kinases.

 

Graduate Students

Stephen Artim, V.M.D.-Ph.D. student

B.S., 2004, Biology/Biochemistry, Haverford College
Graduate group: Biochemistry and Molecular Biophysics

sartim @ vet.upenn.edu

Research Interest: I am using structural and biochemical techniques to study the tyrosine kinase domains of the Trk family of receptor tyrosine kinases. The Trk receptors have been implicated in various diseases and understanding the mechanism of autoinhibition and activation will likely benefit the design of specific inhibitors.

 

Nicholas Bessman

Nicholas Bessman, Graduate Student

B.S., 2006, Biochemistry, Iowa State University
Graduate group: Biochemistry and Molecular Biophysics

nichj @ mail.med.upenn.edu

Research Interest: The EGF receptor is an important drug target in several cancers, and a key 'model system' in cellular-signal transduction. My goal is to use biophysical, biochemical, and structural approaches to better understand how the ligand stimulates EGF receptor signaling, with an eye towards improved therapeutics, and a fundamental understanding of how extracellular signals are transmitted across the cell membrane.

 

Jin Park

Jin H. Park, Graduate student

B.A., 2006, Molecular and Cell Biology, University of California, Berkeley
Graduate group: Biochemistry and Molecular Biophysics

jinhpark @ mail.med.upenn.edu

Research Interest: I am currently interested in understanding the regulation of EGFR, ALK and CCK4 kinases and how these RTKs (receptor tyrosine kinases) mediate cellular signaling based on biochemical, binding and structural studies with cell-based assays.

Matt Rapp

Matthew Rapp, Graduate student

B.S., 2012, Biochemistry and Molecular Biology, University of Maryland Baltimore County
Graduate group: Cell and Molecular Biology

mattrapp @ mail.med.upenn.edu

Research Interest: There is little understood about the signaling mechanism of the receptor tyrosine kinase ALK. I am interested in understanding ALK signaling in the context of neuroblastomas and how this signaling compares to that of wild-type ALK receptors.

Kelsey Speer, Graduate Student

B.A., 2010, Biology, Macalester College
Graduate group: Cell and Molecular Biology

kspeer @ mail.med.upenn.edu

Research Interest: I spent one year working as a trainee at the National Institutes of Health in Bethesda, Maryland before joining the Lemmon lab in 2012. My current interests include the role of non-canonical receptor tyrosine kinases in Wnt signaling, with an emphasis on in vivo modeling using Xenopus laevis. My thesis project is being co-mentored by Dr. Peter Klein.

 

Neo Zhengyi Wu, Graduate Student

B.S., 2007, Chemistry, Nanjing University
M.S., 2009, Inorganic Biological Chemistry, Nanjing University
Graduate group: Biochemistry and Molecular Biophysics

zhengyi @ mail.med.upenn.edu

Research Interest: I am interested in understanding cell signaling at molecular and systems levels and developing potential cancer therapeutics. I am also very interested in developing novel computational algorithms to model and learn biological systems.

 

 

Alumni / Current Position

Diego Alvarado / Senior Scientist, Kolltan Pharmaceuticals, New Haven, CT
Mark A. Baumeister / Researcher, New Technologies at Siemens Diagnostics
Mitchell B. Berger / Fellow in Female Pelvic Medicine and Reconstructive Surgery, University of Michigan
Kelley A. Bethoney / High School Teacher at The Episcopal Academy
Scott Bresler / Resident, Anatomic and Clinical Pathology, Brigham and Women's Hospital
Sung-Hee H. Choi / Post Doc at Brigham and Women's Hospital
Jessica P. Dawson / Principal Investigator, EMD Pharmaceuticals, Inc.
Jennifer Kavran / PostDoc at Johns Hopkins
David Keleti / Medical Writer at Percolation Communications
Jon Kenniston / Senior Scientist, Dyax Pharmaceuticals, Inc.
Megan C. King / Assistant Professor, Yale University
Daryl E. Klein / Postdoctoral Fellow at Harvard University Medical School
Anthony Lee / Postdoc fellow, UCLA
Katarina Moravcevic / Post Doc at University of Pennsylvania
Valerie M. Nappi / Assistant Professor, St. Joseph’s College, New York
Kartik Narayan / Group Leader, Merck Pharmaceuticals
Fumin Shi / Consultant, GenScript USA, Inc.
Jong W. Yu / Group Leader, GSK