Mark A. Lemmon, Ph.D.
B.A., 1988, University of Oxford
Pamela Burgess-Jones, Lab Manager
B.A., 1995, Biology, Cheyney Universitypbjones@mail.med.upenn.edu
Anatoly Kiyatkin, Ph.D., Senior Research Investigator
M.S., 1983, Physics, Moscow Institute of Physics and Technology
akiyat @ mail.med.upenn.edu
Research Interest: My research is focused on the analysis of the dynamics of RTK-mediated cell signaling networks with a goal to understand design principles of regulatory network structures that are crucial for network function and cell fate decisions. To reconstruct signaling routes from receptors at the plasma membrane to the activation of MAPK and immediate early genes I use systematic perturbations and measure activation patterns of signaling proteins. Combining experimental studies with computational modeling allows gaining an integrative picture of the cytoplasmic signaling and its regulation. This helps in determining network vulnerabilities and targeting them with molecular therapeutics.
Jeannine Mendrola, Ph.D., Research Associate
B.A., 1990, Biochemistry, University of Pennsylvania
mendrola @ yahoo.com
Research Interest: Currently I am interested in elucidating the mechanism of activation of the Ror2 family of receptor tyrosine kinases in non-canonical Wnt signaling emphasizing structure-function relationships.
Dan Freed, Ph.D. Postdoctoral Fellow
NIH Ruth L. Kirschstein NRSA F32 Fellowship
B.S., 2006, Chemistry, University of North Carolina Wilmington
danfreed @ mail.med.upenn.edu
Research Interest: I am interested in understanding the structural basis of transmembrane signaling by the EGF receptor. Although the EGFR is one of the most well-studied proteins, the allosteric mechanisms by which different regions of the receptor communicate remain poorly understood. Towards this end, I am combining techniques in structural biology, biophysics and biochemistry to examine conformational changes associated with the activation of intact receptor dimers reconstituted into a physiologically-relevant membrane context.
Jason Moore, Ph.D., Postdoctoral Fellow
American Cancer Society Fellowship
B.S., 2000, Biology, Pennsylvania State University
jamoore @ mail.med.upenn.edu
Research Interest: My research is focused on the structural basis of signaling in receptor tyrosine kinases that contain extracellular FNIII domains. Using a variety of tools, from biophysical methods to cellular studies, my goal is to determine whether these FNIII domains have a uniform role in mediating receptor dimerization and activation. My graduate work was performed in Wayne Hendrickson's lab at Columbia University where I studied signaling in the TorT-TorS-TorR bacterial two-component system.
Jin H. Park, Graduate student
B.A., 2006, Molecular and Cell Biology, University of California, Berkeley
jinhpark @ mail.med.upenn.edu
Research Interest: I am currently interested in understanding the regulation of EGFR, ALK and CCK4 kinases and how these RTKs (receptor tyrosine kinases) mediate cellular signaling based on biochemical, binding and structural studies with cell-based assays.
Kelsey Speer, Graduate Student
B.A., 2010, Biology, Macalester College
kspeer @ mail.med.upenn.edu
Research Interest: I spent one year working as a trainee at the National Institutes of Health in Bethesda, Maryland before joining the Lemmon lab in 2012. My current interests include the role of non-canonical receptor tyrosine kinases in Wnt signaling, with an emphasis on in vivo modeling using Xenopus laevis. My thesis project is being co-mentored by Dr. Peter Klein.
Hollis De Laney, Undergraduate student
hollisd @ sas.upenn.edu
Research Interest: I am currently studying EGFR point mutations in order to provide computational models with the data required to increase the precision of systems used in predicting oncogenicity. My general interests lie in protein structure and its relationships to function and disease.
Alumni / Current Position
Diego Alvarado / Senior Scientist, Kolltan Pharmaceuticals, New Haven, CT
Stephen Artim / VMD Student at University of Pennsylvania
Mark A. Baumeister / Senior Biochemist, Siemens Healthcare Diagnostics
Mitchell B. Berger / Fellow in Female Pelvic Medicine and Reconstructive Surgery, University of Michigan
Nicholas Bessman / Postdoctoral Researcher, Weill Cornell Medical College
Kelley A. Bethoney / High School Teacher at The Episcopal Academy
Scott Bresler / Resident, Anatomic and Clinical Pathology, Brigham and Women's Hospital
Sung-Hee H. Choi / Postdoctoral Fellow at Brigham and Women's Hospital
Jessica P. Dawson / Principal Investigator, EMD Pharmaceuticals, Inc.
Jennifer Kavran / Postdoctoral Fellow at Johns Hopkins
David Keleti / Medical Writer at Percolation Communications
Jon Kenniston / Senior Scientist, Dyax Pharmaceuticals, Inc.
Megan C. King / Assistant Professor, Yale University
Daryl E. Klein / Postdoctoral Fellow at Harvard University Medical School
Anthony Lee / Programmer, City Morph Studio
Katarina Moravcevic / Postdoctoral Fellow at University of Pennsylvania
Valerie M. Giordano / Associate Professor, St. Joseph’s College, New York
Kartik Narayan / Group Leader, Merck Pharmaceuticals
Camilla Oxley / Licensing Officer, Penn Center for Innovation
Fumin Shi / Consultant, GenScript USA, Inc.
Jong W. Yu / Group Leader, GSK
Neo Zhengyi Wu / Software Engineer | Scientist, Independent