LAB MEMBERS

Mark Lemmon

Mark A. Lemmon, Ph.D.
George W. Raiziss Professor of Biochemistry and Biophysics
Chair, Department of Biochemistry and Biophysics

B.A., 1988, University of Oxford
M. Phil., 1990, Yale University
Ph.D., 1993, Yale University

mlemmon@mail.med.upenn.edu

 

Administrative Staff

Pam Burgess-Jones

Pamela Burgess-Jones, Lab Manager

B.A., 1995, Biology, Cheyney University

pbjones@mail.med.upenn.edu
215-898-3411

Patti Thorp

Patti Thorp, M.A. Executive Assistant

B.A., 1989, Linguistics, Pennsylvania State University
M.A., 1994, Linguistics, University of Pennsylvania

thorp@mail.med.upenn.edu
215-898-1876

Researchers

Anatoly Kiyatkin

Anatoly Kiyatkin, Ph.D., Senior Research Investigator

M.S., 1983, Physics, Moscow Institute of Physics and Technology
PhD, 1986, Biophysics, Moscow Institute of Physics and Technology

akiyat @ mail.med.upenn.edu

Research Interest: My research is focused on the analysis of the dynamics of RTK-mediated cell signaling networks with a goal to understand design principles of regulatory network structures that are crucial for network function and cell fate decisions. To reconstruct signaling routes from receptors at the plasma membrane to the activation of MAPK and immediate early genes I use systematic perturbations and measure activation patterns of signaling proteins. Combining experimental studies with computational modeling allows gaining an integrative picture of the cytoplasmic signaling and its regulation. This helps in determining network vulnerabilities and targeting them with molecular therapeutics.

 

Jeannine Mendrola

Jeannine Mendrola, Ph.D., Research Associate

B.A., 1990, Biochemistry, University of Pennsylvania
PhD, 1998, Genetics, Thomas Jefferson University

mendrola @ yahoo.com

Research Interest: Currently I am interested in elucidating the mechanism of activation of the Ror2 family of receptor tyrosine kinases in non-canonical Wnt signaling emphasizing structure-function relationships.

Postdoctoral Researchers

Dan Freed, Ph.D. Postdoctoral Fellow

NIH Ruth L. Kirschstein NRSA F32 Fellowship

B.S., 2006, Chemistry, University of North Carolina Wilmington
Ph.D., 2012, Chemistry, University of Virginia

danfreed @ mail.med.upenn.edu

Research Interest: I am interested in understanding the structural basis of transmembrane signaling by the EGF receptor. Although the EGFR is one of the most well-studied proteins, the allosteric mechanisms by which different regions of the receptor communicate remain poorly understood. Towards this end, I am combining techniques in structural biology, biophysics and biochemistry to examine conformational changes associated with the activation of intact receptor dimers reconstituted into a physiologically-relevant membrane context.

 

Jason Moore

Jason Moore, Ph.D., Postdoctoral Fellow

American Cancer Society Fellowship

B.S., 2000, Biology, Pennsylvania State University
M.S., 2001, Biochemistry and Molecular Biophysics, Columbia University
M.Phil., 2003, Biochemistry and Molecular Biophysics, Columbia University
Ph.D., 2009, Biochemistry and Molecular Biophysics, Columbia University

jamoore @ mail.med.upenn.edu

Research Interest: My research is focused on the structural basis of signaling in receptor tyrosine kinases that contain extracellular FNIII domains. Using a variety of tools, from biophysical methods to cellular studies, my goal is to determine whether these FNIII domains have a uniform role in mediating receptor dimerization and activation. My graduate work was performed in Wayne Hendrickson's lab at Columbia University where I studied signaling in the TorT-TorS-TorR bacterial two-component system.

Graduate Students

Jin Park

Jin H. Park, Graduate student

B.A., 2006, Molecular and Cell Biology, University of California, Berkeley
Graduate group: Biochemistry and Molecular Biophysics

jinhpark @ mail.med.upenn.edu

Research Interest: I am currently interested in understanding the regulation of EGFR, ALK and CCK4 kinases and how these RTKs (receptor tyrosine kinases) mediate cellular signaling based on biochemical, binding and structural studies with cell-based assays.

Kelsey Speer, Graduate Student

B.A., 2010, Biology, Macalester College
Graduate group: Cell and Molecular Biology

kspeer @ mail.med.upenn.edu

Research Interest: I spent one year working as a trainee at the National Institutes of Health in Bethesda, Maryland before joining the Lemmon lab in 2012. My current interests include the role of non-canonical receptor tyrosine kinases in Wnt signaling, with an emphasis on in vivo modeling using Xenopus laevis. My thesis project is being co-mentored by Dr. Peter Klein.

 

Neo Zhengyi Wu, Graduate Student

B.S., 2007, Chemistry, Nanjing University
M.S., 2009, Inorganic Biological Chemistry, Nanjing University
Graduate group: Biochemistry and Molecular Biophysics

zhengyi @ mail.med.upenn.edu

Research Interest: I am interested in understanding cell signaling at molecular and systems levels and developing potential cancer therapeutics. I am also very interested in developing novel computational algorithms to model and learn biological systems.

 

Undergraduate Students

Molly Brothers

Molly Brothers, Undergraduate student

Major: Molecular Biology

mollybro @ sas.upenn.edu

Research Interest: I am interested in studying the structure and function of cellular proteins and their roles in diseases such as cancer and HIV.

Hollis De Laney

Hollis De Laney, Undergraduate student

Major: Biochemistry

hollisd @ sas.upenn.edu

Research Interest: I am currently studying EGFR point mutations in order to provide computational models with the data required to increase the precision of systems used in predicting oncogenicity. My general interests lie in protein structure and its relationships to function and disease.

Derek Yee

Derek Yee, Bioengineering

Major: Biochemistry

yeed @ seas.upenn.edu

Research Interest: I am currently researching point mutations within the EGFR gene and its effect on developing oncogenes. My research interests include studying protein structures and the functions of proteins. I hope to help create computational models/algorithms based on current research data to help predict cancerous growth in the near future.

 

Alumni / Current Position

Diego Alvarado / Senior Scientist, Kolltan Pharmaceuticals, New Haven, CT
Stephen Artim / VMD Student at University of Pennsylvania
Mark A. Baumeister / Senior Biochemist, Siemens Healthcare Diagnostics
Mitchell B. Berger / Fellow in Female Pelvic Medicine and Reconstructive Surgery, University of Michigan
Nicholas Bessman / Postdoctoral Researcher, Weill Cornell Medical College
Kelley A. Bethoney / High School Teacher at The Episcopal Academy
Scott Bresler / Resident, Anatomic and Clinical Pathology, Brigham and Women's Hospital
Sung-Hee H. Choi / Postdoctoral Fellow at Brigham and Women's Hospital
Jessica P. Dawson / Principal Investigator, EMD Pharmaceuticals, Inc.
Jennifer Kavran / Postdoctoral Fellow at Johns Hopkins
David Keleti / Medical Writer at Percolation Communications
Jon Kenniston / Senior Scientist, Dyax Pharmaceuticals, Inc.
Megan C. King / Assistant Professor, Yale University
Daryl E. Klein / Postdoctoral Fellow at Harvard University Medical School
Anthony Lee / Programmer, City Morph Studio
Katarina Moravcevic / Postdoctoral Fellow at University of Pennsylvania
Valerie M. Giordano / Associate Professor, St. Joseph’s College, New York
Kartik Narayan / Group Leader, Merck Pharmaceuticals
Camilla Oxley / Licensing Officer, Penn Center for Innovation
Fumin Shi / Consultant, GenScript USA, Inc.
Jong W. Yu / Group Leader, GSK