The immune response is an important interface between the pathogen and host.
Penn investigators study vaccine development for a number of infectious agents,
including HIV, smallpox, herpes simplex, and Ebola. In addition, infectious agents
such as listeria monocytogenes are used to study basic immunology, such as the
induction of immunologic memory.
| David Artis |
Immunology and cell biology of parasitic helminth infections;
regulation of innate and adaptive immunity in the gut |
| Michael Betts |
HIV immunopathogenesis; antiviral immunity; vaccines |
| Kyong-Mi Chang |
Hepatitis C virus persistence and immune response |
| Sara Cherry |
Innate anti-viral mechanisms in Drosophila |
| Gudrun Debes |
Protective and pathologic immune responses; lymphocyte
migration in inflammation and infection |
| Robert Doms |
HIV pathogenesis; flaviviruses; humoral immune response |
| Hildegund
Ertl |
Vaccines; rabies; HIV-1; HPV-16; poxvirus; mechanisms
of protection; T cell memory; maturation of dendritic
cells |
| Terri
Finkel |
HIV pathogenesis; apoptosis; immune cell signaling and
tolerance |
| Fred Frankel |
Listeria monocytogenes; vaccines |
| Harvey
Friedman |
HSV pathogenesis; immune evasion; HSV vaccines |
| Glen
Gaulton |
HIV and murine leukemia virus entry and pathogenesis |
| James
Hoxie |
HIV and SIV pathogenesis; viral entry; humoral immune
response; chemokine receptors |
| Chris Hunter |
innate and adaptive immunity to infection; immune pathology;
cytokine biology; cell biology of intracellular parasites;
neuroimmunology |
| Stuart
Isaacs |
Vaccinia virus; recombinant vaccines; poxviruses; counter-bioterrorism |
| Phil Johnson |
SIV; HIV; AAV; vaccine; gene transfer |
| Carl
June |
HIV pathogenesis; HIV immunotherapy |
| Luis
Montaner |
HIV immunopathogenesis; innate immunity; cytokines |
| Oliver,
Paula |
Lymphocyte activation and tolerance; T cell response
to pathogen infection; HECT-type E3 ubiquitin ligases |
| Yvonne Paterson |
Tumor immunology; Listeria monocytogenes; vaccines
against infectious and neoplastic disease |
| Ed Pearce |
Schistosomiasis; parasitic helminth; Th1/Th2 responses;
dendritic cells |
| Robert
Ricciardi |
Adenovirus; Human Kaposi’s Sarcoma Virus; immune
escape |
| Jim
Riley |
HIV pathogenesis; lentiviral vectors; immune reconsititution |
| David Roos |
Molecular/cellular parasitology; toxoplasma; plasmodium
(malaria); genomics |
| Susan Ross |
Virus/host interactions; MMTV; genetics of susceptibility
to virus infection |
| Dieter
Schifferli |
Escherichia coli and Salmonella pathogenesis; fimbriae;
vaccines |
| Phil
Scott |
T helper cell subsets; IL-12; T cell memory; Leishmania |
| Hao Shen |
T cell responses and memory; immune evasion |
| Luis Sigal |
Mechanisms of cross presentation during viral infections |
| Guido Silvestri |
HIV/SIV, T cells, apoptosis, non-human primates,cCell
cycle, T cell homeostasis |
| David Weiner |
HIV vaccines; DNA vaccines; West Nile virus; cellular
immune responses |
| Susan Weiss |
Murine coronavirus CNS pathogenesis; coronavirus induced
hepatitis |
| Drew
Weissman |
HIV; dendritic; mRNA; RNA interference; siRNA; vaccine;
HIV coreceptor |
| John
Wherry |
Viral pathogenesis; chronic infections; CD8 T Cell
differentiation; therapeutic vaccination |
| James
Wilson |
Ebola virus; viral vectors; primate parvoviruses |
| Yan
Yuan |
Mechanism of herpesvirus avoiding immune detection and
defenses |
