The immune response is an important interface between the pathogen and host.
Penn investigators study vaccine development for a number of infectious agents,
including HIV, smallpox, herpes simplex, and Ebola. In addition, infectious agents
such as listeria monocytogenes are used to study basic immunology, such as the
induction of immunologic memory.
| David Artis |
Immunology and cell biology of parasitic helminth infections;
regulation of innate and adaptive immunity in the gut |
| Michael Betts |
HIV immunopathogenesis; antiviral immunity; vaccines |
| Igor Brodsky |
Host-pathogen interactions; bacterial pathogenesis;
Yersinia; innate immunity |
| Kyong-Mi Chang |
Hepatitis C virus persistence and immune response |
| Sara Cherry |
Innate anti-viral mechanisms in Drosophila |
| Gudrun Debes |
Protective and pathologic immune responses; lymphocyte
migration in inflammation and infection |
| Robert Doms |
HIV pathogenesis and the humoral immune response |
| Hildegund
Ertl |
Vaccines; rabies; HIV-1; HPV-16; poxvirus; mechanisms
of protection; T cell memory; maturation of dendritic
cells |
| Terri
Finkel |
HIV pathogenesis; apoptosis; immune cell signaling and
tolerance |
| Fred Frankel |
Listeria monocytogenes; vaccines |
| Harvey
Friedman |
HSV pathogenesis; immune evasion; HSV vaccines |
| Glen
Gaulton |
HIV and murine leukemia virus entry and pathogenesis |
| Scott Hensley |
Influenza virus; antigenic drift; viral pathogenesis; antibody specificity; vaccines |
| James
Hoxie |
HIV and SIV pathogenesis; viral entry; humoral immune
response; chemokine receptors |
| Chris Hunter |
Innate and adaptive immunity to infection; immune pathology;
cytokine biology; cell biology of intracellular parasites;
neuroimmunology |
| Stuart
Isaacs |
Vaccinia virus; recombinant vaccines; poxviruses; counter-bioterrorism |
| Phil Johnson |
SIV; HIV; AAV; vaccine; gene transfer; antibodies |
| Carl
June |
HIV pathogenesis; HIV immunotherapy |
| Rahul Kohli |
Antibody diversity; innate immune retroviral restriction
resistance |
| Carolina Lopez |
Influenza virus; paramyxoviruses; respiratory viral
infections; virus sensors, anti-viral immunity;
systemic innate response |
| Luis
Montaner |
HIV immunopathogenesis; innate immunity; cytokines |
| Paula
Oliver |
Lymphocyte activation and tolerance; T cell response
to pathogen infection; HECT-type E3 ubiquitin ligases |
| Yvonne Paterson |
Tumor immunology; Listeria monocytogenes; vaccines
against infectious and neoplastic disease |
| Robert
Ricciardi |
Adenovirus; Human Kaposi’s Sarcoma Virus; immune
escape |
| Jim
Riley |
HIV pathogenesis; lentiviral vectors; immune reconsititution |
| David Roos |
Molecular/cellular parasitology; toxoplasma; plasmodium
(malaria); genomics |
| Susan Ross |
Innate and intrinsic immune responses to viruses; retroviruses; arenaviruses |
| Dieter
Schifferli |
Escherichia coli and Salmonella pathogenesis; fimbriae;
vaccines |
| Phil
Scott |
T helper cell subsets; IL-12; T cell memory; Leishmania |
| George Shaw |
HIV and SIV pathogenesis; virus transmission; HCV pathogenesis;
humoral immune responses |
| Hao Shen |
T cell response and memory; vaccine; immune evasion by microbes |
| Sunny Shin |
Immunity against bacterial pathogens; bacterial pathogenesis;
Legionella pneumophila |
| David Weiner |
HIV vaccines; DNA vaccines; West Nile virus; cellular
immune responses |
| Jeff Weiser |
Relationship between innate immunity and bacterial
colonization |
| Susan Weiss |
Murine coronavirus pathogenesis; organ specific virus-cell interactions; viral antagonism of the OAS-RNase L pathway; T cell response in the central nervous system |
| Drew
Weissman |
HIV; dendritic; mRNA; RNA interference; siRNA; vaccine;
HIV coreceptor |
| E. John
Wherry |
Viral pathogenesis; chronic infections; CD8 T Cell
differentiation; therapeutic vaccination |
| James
Wilson |
Ebola virus; viral vectors; primate parvoviruses |
| Yan
Yuan |
Mechanism of herpesvirus avoiding immune detection and
defenses |
