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Neurovirology Research
Viral infections of the central nervous system (CNS) differ from infections
of other organs in that the CNS is somewhat isolated from the periphery by
the blood brain barrier and this results in different host responses to infection.
The University of Pennsylvania has a long history of research in neurovirology,
organized originally by Dr. Neal Nathanson, one of the pioneers of neurovirology,
in the late 1970's. A training grant in Neurovirology has funded postdocs
and predocs trainees at Penn for the last thirty years. The neurovirology
group includes investigators from the University of Penn schools of medicine,
dentistry and veterinary medicine as well as the Fox Chase Cancer Center.
Studies focus on virus-receptor interaction during viral entry and spread
and pathogenesis of infection of the CNS, including the use of viruses for
gene therapy of the CNS and investigation of host factors involved in pathogenesis
of neurotropic viruses. A variety of viruses are studied including Herpes
simplex virus, HIV and other retroviruses, measles , bunyaviruses, alphaviruses
and coronaviruses.
Neurovirology Researchers At University of Pennsylvania
| Sara Cherry |
Host factors important for encephalitic
alphaviruses and bunyaviruses |
| Gary
Cohen |
HSV-1 glycoproteins & receptors; virus entry |
| Ron
Collman |
HIV/SIV tropism and entry; neuroAIDS; microbiome of the respiratory tract |
| Roselyn
Eisenberg |
HSV-1 glycoproteins & receptors |
| Nigel Fraser |
HSV latency; gene transfer to neurons |
| Glen
Gaulton |
HIV and murine leukemia virus entry and pathogenesis |
| Kelly Jordan-Sciutto |
Viral encephalitis; neuroinflammation; neuropathogenesis; HIV; antiretroviral therapy; oxidative stress; endoplasmic reticulum stress |
| Dennis
Kolson |
Neurobiology of HIV injury; oxidative stress; survival
pathways |
Glenn Rall
(Fox Chase Cancer Center) |
Spread of neurotropic viruses; antiviral responses
in the brain |
Matthias Schnell
(Thomas Jefferson University)
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Virology, neurovirology, CNS infection by rabies virus |
| Sam Soldan |
Bunyaviruses; LaCrosse Virus |
| Susan Weiss |
Murine coronavirus pathogenesis; organ specific virus-cell interactions; viral antagonism of the OAS-RNase L pathway; T cell response in the central nervous system |
| Matthew Weitzman |
Host cell interaction and restriction factors |
| John
Wolfe |
Viral vectors for gene transfer to CNS; neural stem
cell transplantation |
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