Virology has long been a significant strength at the University of Pennsylvania,
with viral pathogenesis being a particular area of expertise. Research on
HIV
is coordinated by the Center for AIDS Research and involves investigators at
Penn, Children's Hospital, Fox Chase Cancer Center, and the Wistar Institute
who study virus entry, vaccine development,
neuropathogenesis, replication, and small molecule inhibitors. A large number
of investigators study herpes viruses, characterizing their cell surface receptors,
mechanisms of latency, and in the case of EBV and KSHV their ability to transform
cells. Many other viruses are studied by investigators in the Microbiology
program,
including MMTV, murine coronaviruses, SARS, SV40, adenoviruses, bunyaviruses
including
Crimean Congo Hemorrhagic Fever and Rift Valley fever, and coxsackie
viruses. You can click on Emerging
Infectious Diseases under Research to learn more about investigators who
study emerging viral diseases, and on Tumor Virology to learn about work in
this
area as well.
| James
Alwine |
Tumor virology; HCMV; stress response signaling; mTOR; metabolism; dynein; kinesin |
| Paul Bates |
Virus-host interactions; tetherin; bunyaviruses; ebolavirus |
| Jeff
Bergelson |
Virus receptors; picornavirus entry; adenovirus vectors |
| Michael Betts |
HIV immunopathogenesis; antiviral immunity; vaccines |
| Frederic
Bushman |
Virology; bacteriology; HIV; microbiome research; DNA integration; human gene therapy |
| Kyong-Mi Chang |
Hepatitis C virus persistence and immune response |
| Sara Cherry |
Host factors required for viral pathogenesis |
| Gary
Cohen |
HSV-1 glycoproteins & receptors |
| Ron
Collman |
HIV tropism |
| Gudrun Debes |
Host protection against influenza A virus infection |
| Robert Doms |
HIV pathogenesis; flaviviruses; bunyaviruses; humoral
immune response |
| Roselyn
Eisenberg |
HSV-1 glycoproteins & receptors |
| Terri
Finkel |
HIV pathogenesis; apoptosis; immune cell signaling and
tolerance |
| Nigel Fraser |
Herpes simplex virus latency; gene & cancer therapy |
| Harvey
Friedman |
HSV pathogenesis; immune evasion; HSV vaccines |
| Glen
Gaulton |
HIV and MLV diagnostics and pathogenesis |
| Beatrice
Hahn |
Zoonotic potential and pathogenesis of primate lentiviruses |
| Ron
Harty |
Ebola + Marburg; VSV; Lassa fever + Junin; host interactions; assembly/budding; innate immunity; antivirals |
| Scott Hensley |
Influenza virus; viral receptors; antigenic drift;
viral pathogenesis; vaccines |
| James
Hoxie |
HIV and SIV pathogenesis; viral entry; humoral immune
response; chemokine receptors |
| Stuart
Isaacs |
Vaccinia virus; recombinant vaccines; poxviruses; counter-bioterrorism |
| Phil Johnson |
SIV; HIV; AAV; vaccine; gene transfer |
| Kelly Jordan-Sciutto |
Mechanisms of neuronal death; molecular mechanisms
underlying neuronal loss in neurodegenerative disorders;
neuronal responses in HIV encephalitis |
| Rahul Kohli |
HIV; innate defense factors; viral evolution and drug resistance |
| Dennis
Kolson |
HIV neuropathogenesis; apoptosis; survival pathways |
| Paul
Lieberman |
Tumor virology; latency; epigenetics; chromosome biology; drug discovery |
| Carolina Lopez |
Influenza virus; paramyxoviruses; respiratory viral infections; virus sensors, anti-viral immunity; systemic innate response |
| Luis
Montaner |
HIV immunopathogenesis; innate immunity; cytokines |
| Una
O'Doherty |
HIV-1 latency; HIV-1 reservoirs; resting T cells; dendritic
cells |
| Yvonne Paterson |
Tumor immunology; Listeria monocytogenes; vaccines
against infectious and neoplastic disease |
| Glenn Rall |
Viral infection of the CNS; viral immunology; polymicrobial infections |
| Robert
Ricciardi |
Adenovirus; Human Kaposi’s Sarcoma Virus; immune
escape |
| Jim
Riley |
HIV pathogenesis; lentiviral vectors; immune reconsititution |
| Erle Robertson |
Tumor viruses; EBV associated lymphomas; gene regulation;
cancer biology |
| Susan Ross |
Virus/host interactions; MMTV; genetics of susceptibility
to virus infection |
| George Shaw |
HIV and SIV pathogenesis; virus transmission; HCV pathogenesis;
humoral immune responses |
| David Weiner |
DNA Vaccines; HIV vaccines; T cell responses; immune therapy of infection |
| Susan Weiss |
Murine coronavirus pathogenesis; organ specific virus-cell interactions; viral antagonism of the OAS-RNase L pathway; T cell response in the central nervous system |
| Drew
Weissman |
HIV; dendritic; mRNA; RNA interference; siRNA; vaccine;
HIV coreceptor |
| Matthew Weitzman |
Virus-host interactions; replication and restriction
of DNA viruses; gene delivery vectors |
| E.
John Wherry |
Viral pathogenesis; chronic infections; CD8 T cell differentiation; T cell exhaustion; immune checkpoints |
| James
Wilson |
Ebola virus; viral vectors; primate parvoviruses |
| Jianxin You |
Human papillomavirus; Merkel cell polyomavirus; Virus-host interaction; DNA damage response; episome maintenance; tumorigenesis |
| Yan
Yuan |
Kaposi's sarcoma-associated herpesvirus; virus-host
interaction |
