What's New

Seminars, Special Events, Research Grants:

Some Research Publications of Note:

Guanylate-binding proteins: niche recruiters for antimicrobial effectors Immunity (2012)
Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing PLoS Pathgens (2012)
The Battle over mTOR: An Emerging Theatre in Host-Pathogen Immunity PLoS Pathogens (2012)
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape PLoS Pathogens (2012)
The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology Immunity (2012)
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 PLoS Pathogens (2012)
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells Sci Transl Med (2012)
Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency PLoS Pathogens (2012)
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation Nature Med (2012)
Forum: Immunology: Allergy challenged. Science (2012)
Immunology. Rebuilding the thymus. Science (2012)
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria Science (2012)
Commensal bacteria calibrate the activation threshold of innate antiviral immunity Immunity (2012)
New paradigms in type 2 immunity Science (2012)
Virus recognition by Toll-7 activates antiviral autophagy in Drosophila Immunity (2012)
AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis PLoS Pathog. (2012)
Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism Cell Host Microbe (2012)
Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase PNAS
(2012)
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells Nature
(2012)
Targeted hypervariation in the human gut virome PNAS
(2012)
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology Cell Host
Microbe
(2012)
E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells PLoS Pathogens
(2012)
TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentation Nature Imm.
(2012)
Hypervariable loci in the human gut virome PNAS
(2012)
TCR affinity and specificity requirements for human T regulatory cell function Blood
(2012)
Kaposi's Sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation PLoS Pathogens
(2012)
The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferation PLoS Pathogens
(2012)
Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae PLoS Pathogens
(2012)
Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication PLoS Pathogens
(2011)
Reconciling molecular phylogenies with the fossil record PNAS
(2011)
Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis PLoS Pathogens
(2011)
A critical role for SOCS3 in innate resistance to Toxoplasma gondii Cell Host Microbe
(2011)

Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody

 Cell Host Microbe
(2011)
EBV tegument protein BNRF1 disrupts DAXX-ATRX to activate viral early gene transcription PLOS Pathogens
(2011)
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus Nature Imm.
(2011)
Linking long-term dietary patterns with gut microbial enterotypes Science
(2011)
A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection PloS Pathogens
(2011)
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation Nature
(2011)
Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and Mammalian hosts Cell Host Microbe
(2011)
Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium Cell Host Microbe
(2011)
Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice J Clin Invest
(2011)
Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice J Clin Invest
(2011)
T cell exhaustion Nat. Immunol. (2011)
Transcription factor T-beta represses expression of the inhibitory receptor PD_1 and sustains virus-specific CD8(+) T cell responses uring chronic infection Nat. Immunol. (2011)
The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0 PLoS Pathogens (2011)
Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation Cell Host Microbe (2011)
Cell biology. The lives of proteins Science
(2011)
Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART PLoS Pathogens
(2011)
Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemomphilus influenzae PLoS Pathogens
(2011)
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1 PloS Pathogens
(2011)
Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelian monolayers Cell Host Microbe
(2011)
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 PLoS Pathogens
(2011)
Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

Blood
(2011)

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol.
(2011)
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases PLoS Pathogens
(2011)
Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB PNAS
(2011)
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut Immunity
(2011)

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