Guanylate-binding proteins: niche recruiters for antimicrobial effectors

Dupont CD, Hunter CA. Immunity. 2012 37:191-193.

There are fundamental questions regarding how IFN-γ activates host cells to eliminate intracellular pathogens. In this issue of Immunity, Yamamoto et al. (2012) demonstrate a critical role for the p65 guanylate-binding proteins (GBPs) in this process during infection with Toxoplasma gondii.