Molecular Mechanisms Underlying Neuronal Development and Mental Disorders
Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.
As a newly established group at the University of Pennsylvania Perelman School of Medicine, we are looking forward to being a part of the community at Penn. At this time, we are seeking Postdoctoral Fellows and Graduate Students to join the lab. In addition, the lab is always looking for Undergraduate Students who are enthusiastic about stem cell and neuroscience research. Please contact us to inquire about opportunities within our lab.
Guo-li gave a talk at TEDMED 2017
November 3, 2017
"Neuroscientist Guo-li Ming’s pioneering work with brain organoids led to an early discovery of the link between Zika and microcephaly, which is changing our understanding of disease and potential treatment."
Congratulations to Eunchai Kang and collaborators on their recent publication in Neuron
November 2, 2017
Eunchai Kang published her collaborative work with Mingjie Zhang's group in Hong Kong in NEURON on a multifaceted approach to investigate how risk factors for psychiatric disorders affect neural development using NMR spectroscopy, imaging, animal models, and patient iPSC-derived brain organoids.