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Pilot Project Awardees


2009 Awards

John Chang, M.D.
Instructor of Medicine
Division of Gastroenterology
Universitity of Pennsylvania

Asymmetric cell division as a mechanism for generating diverse T cell fates for colitis

F. Brad Johnson, M.D., Ph.D
Assistant Professor of Pathology and Laboratory Medicine
Institute on Aging
University of Pennsylvania

Role of the intestinal stem cell niche in a mouse model of telomere dysfunction

David Kaplan, M.D., MSc
Assistant Professor of Medicine
Division of Gastroenterology

Cellular immunity in hepatocellular carcinoma, mouse model

Brett Kaufman, Ph.D.
Assistant Professor
Department of Animal Biology
School of Veterinary Medicine

The contribution of mitochondrial DNA organization to liver disease progression

Erle Robertson, Ph.D.
Professor of Medicine
Department of Microbiology
University of Pennsylvania

Identification of microbes associated with gastric carcinomas

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2008 Awards

Wei Guo, PhD
Associate Professor
Department of Biology
University of Pennsylvania

The Role of Exocyst Complex in Intestinal Epithelial Cell Polarity and Secretion

Joshua Friedman, MD, PhD
Assistant Professor
Department of Pediatrics
Children's Hospital of Philadelphia

Chemokine Signaling in Experimental Biliary Artresia

Mark Kahn, MD
Associate Professor of Medicine
Division of Cardiology
University of Pennsylvania School of Medicine

Regulation of GI Development by MATH6 and GATA Transcription Factors

Makoto Senoo, PhD
Assistant Professor
Department of Animal Biology
University of Pennsylvania School of Veterinary Medicine

GI Epithelial Stem Cells and Tumorigenesis

Rebecca Wells, MD
Assistant Professor of Medicine
Division of Gastroenterology
University of Pennsylvania School of Medicine

Isolation of a Toxin Causing Biliary Artresia from Dysphania Species

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2007 Awards

Kendra Bence, PhD
Assistant Professor of Neuroscience
Department of Animal Biology
School of Veterinary Medicine
*Joint RFA w/Vet School

Role of Protein-Tyrosine Phosphatase 1B (PTP1B) in Obesity-related Insulin Resistance and Non-alcoholic Fatty Liver Disease (NAFLD)


Jeffrey M. Bergelson, MD

Associate Professor
Departments of Pediatrics and Microbiology
Children’s Hospital of Philadelphia

Helicobacter pylori Interaction with DAF on Polarized Epithelium

Gerd A. Blobel, MD
Associate Professor
Department of Pediatrics
Children’s Hospital of Philadelphia

MLL3 in Colon Cancer


Marcia Brose, MD, PhD
Assistant Professor
Division of Hematology Oncology
Departments of Medicine and Othorhinoalryngology
Director of Cancer Genetics Laboratory

Genomic Characterization of Esophageal Cancer


Randolph P. Matthews, MD, PhD
Assistant Professor
Department of Pediatrics
Division of GI, Hepatology & Nutrition
Children’s Hospital of Philadelphia

DNA Methylation in Biliary Development and Disease


Ben Z. Stanger, MD, PhD
Assistant Professor of Medicine
Assistant Investigator, Abramson Family Cancer Research Institute

Pancreatic Ductal Purification by Lectin Affinity

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2006 Awards

Kendra Bence, Ph.D.
Assistant Professor of Neuroscience
Department of Animal Biology
School of Veterinary Medicine
*Joint RFA w/Vet School

Role of Protein-Tyrosine Phosphatase 1B (PTP1B) in Obesity-related Insulin Resistance and Non-alcoholic Fatty Liver Disease (NAFLD)


Donna George, Ph.D.
Associate Professor of Genetics
Department of Genetics
*Joint RFA w/Abramson Cancer Center

A p53-IGFBP1 Regulatory Circuit and Liver Cancer


Linda Greenbaum, M.D.
Assistant Professor of Medicine
Division of Gastroenterology

A Novel Model of Nonalcoholic Fatty Liver Disease


Mark Kahn, M.D.
Associate Professor of Medicine
Division of Cardiovascular Medicine

Hematopoietic Contribution to the Gut Vasculature


Carol Maley, Ph.D.
Assistant Professor
Molecular and Cellular Oncogenesis Program
The Wistar Institute

Organotypic Tissue Culture of Barrett's Esophagus


Robert Vonderheide, M.D., D. Phil.
Assistant Professor of Medicine
Division of Hematology/Oncology

Immature Myeloid Cells and Pancreatic Cancer

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2005 Awards

Kyong-Mi Chang, Ph.D.
Assistant Professor of Medicine
Division of Gastroenterology

Influence of HCV gene expression in CD4+CD25+Regulatory T cells in T Vaccinia Viruses expressing HCV


Michael May, MD
Assistant Professor of Medicine
Department of Animal Biology

Molecular and Functional Studies of a Novel NF-kB Pathyway in Pancreatic Cancer Cells


Glenn Radice, PhD
Research Associate Professor
Department of Obstetrics and Gynecology and Cell & Developmental Biology

N-cadherin Function in Pancreatic Cancer


Mei-Lun Wang, MD
Instructor in Pediatrics
Children’s Hospital of Philadelphia

Acute T Cell-Mediated Immune Responses in the Intestine


Xiaolu Yang, MD
Assistant Professor of Medicine
Department of Cancer Biology
Abramson Family Cancer Research Institute

The inhibitor of apoptosis proteins and gastric MALT lymphomas

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2004 Awards

Tracy Bale, Ph.D.
Assistant Professor, Department of Animal Biology
School of Veterinary Medicine

Effects of stress on food intake and metabolism


Volker Haase, M.D.
Assistant Professor of Medicine
Division of Renal, Electrolyte, and Hypertension

The role of hypoxia-inducible factor (HIF) in the pathogenesis of VHL associated liver hemangiomas


John Lynch, M.D., Ph.D.
Assistant Professor of Medicine
Division of Gastroenterology

Role of the homeodomain transcription factors CDx1 and CDx2 in murine intestinal carcinogenesis


Hiroshi Nakagawa, M.D., Ph.D.
Research Assistant Professor of Medicine
Division of Gastroenterology

Isolation and characterization of esophageal stem cells


Andrei Thomas-Tikhonenko, Ph.D.
Assistant Professor, School of Veterinary Medicine

The inhibitory role of clusterin in colon cancer growth and neovascularization


Xiaolu Yang, Ph.D.
Assistant Professor, Department of Cancer Biology

The inhibitor of apoptosis proteins and gastric MALT lymphomas

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2003 Awards

David Artis, Ph.D.
Instructor, Department of Pathobiology
School of Veterinary Medicine

NF-kB: a transcriptional regulator of IL-10 production and infection-induced intestinal inflammation


Tracy Bale, Ph.D.
Assistant Professor, Department of Animal Biology
School of Veterinary Medicine

Effects of stress on food intake and metabolism


Volker Haase, M.D.
Assistant Professor of Medicine
Division of Renal, Electrolyte, and Hypertension

The role of hypoxia-inducible factor (HIF) in the pathogenesis of VHL associated liver hemangiomas


Marcelo Kazanietz, Ph.D.
Associate Professor of Pharmacology

Beta-2-chimaerin and colon carcinogenesis


Hiroshi Nakagawa, M.D., Ph.D.
Research Assistant Professor of Medicine
Division of Gastroenterology

Isolation and characterization of esophageal stem cells


Michael Olson, Ph.D.
Assistant Professor, Abramson Family Cancer Research Institute

The rock kinase in colon carcinoma cell invasion


Andrei Thomas-Tikhonenko, Ph.D.
Assistant Professor, School of Veterinary Medicine

The inhibitory role of clusterin in colon cancer growth and neovascularization

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2002 Awards

Rexford Ahima, M.D., Ph.D.
Assistant Professor of Medicine
Division of Endocrinology, Diabetes and Metabolism

CNS Action of Appetite Suppressant Aminosterol Derived from the Shark


David Artis, PhD
Instructor
Department of Pathobiology
School of Veterinary Medicine

The Role of NF-kB in Resistance to Intestinal Infection and Inflammation


Debabrata Chakravarti, Ph.D.
Assistant Professor
Department of Pharmacology

Connecting Colon Tumors, P53, and a Novel Human Cellular Complex INHAT


Xianxin Hua, M.D., Ph.D.
Assistant Professor
Department of Cancer Biology

Cooperation of TGF-B and Retinoic Acid in Inhibition of Colon Cancer Cells


Carl June, MD
Professor of Medicine
Dept of Pathology & Laboratory Medicine

Characterization of CTLs and Regulatory T Cells in Hepatitis C Virus Infection


Jonathan Katz, MD
Instructor of Medicine
Division of Gastroenterology

The Role of the Kruppel-like Factor Klf5 in Gastrointestinal Proliferation and Differentiation in Vivo


John Lynch, MD, PhD
Assistant Professor
Division of Gastroenterology

Changes in Gene Expression Profiles Induced by the Homeodomain Transcription Factors Cdx1 and Cdx2 in Human Colon Cancer Cell Lines


Yu Xiao Yang, MD
Instructor of Medicine
Division of Gastroenterology

Non-Insulin Dependent Diabetes Mellitus and Colorectal Cancer

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2001 Awards

Rexford Ahima, M.D., Ph.D.
Assistant Professor of Medicine
Division of Endocrinology, Diabetes and Metabolism

CNS Action of Appetite Suppressant Aminosterol Derived from the Shark


Debabrata Chakravarti, Ph.D.
Assistant Professor
Department of Pharmacology

Connecting Colon Tumors, p53 and a Novel Human Cellular Complex INHAT


George Cotsarelis, M.D.
Assistant Professor
Department of Dermatology

Mouse Model for Barrett’s Esophagus


Xianxin Hua, M.D., Ph.D.
Assistant Professor
Department of Cancer Biology

Retinoic Acid in Inhibition of Colon Cancer Cells


J. Eric Russell, M.D.
Assistant Professor of Medicine
Hematology-Oncology Division

Post-Transcriptional Regulation of Prothrombin Gene Expression


John Seykora, M.D., Ph.D.
Instructor
Department of Dermatology

The Role of Srcasm in Epithelial Differentiation

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2000 Awards

Margret Casal, D.V.M., Ph.D.
Department of Clinical Studies
School of Veteriniary Medicine

Biology of Engraftment and Distribution of Murine Fetal Cells After In Utero Transplantation.


Gregory H. Enders, M.D., Ph.D.
Department of Medicine
Division of Gastroenterology

Regulation and Role of the Tumor Suppressor p16INK4a in Intestinal Neoplasia


Peter Felsburg, V.M.D., Ph.D.
Department of Clinical Studies
School of Veteriniary Medicine

Role of the Common Gamma Chain and its Associated Cytokines in the Hemeostatic Regulation of the Intestinal Eptihelium


Arupa Ganguly, Ph.D.
Department of Genetics

Role of DNA Mismatch Repair Genes in Families with Breast, Ovarian and Colon Cancer


David Gasser, Ph.D.
Department of Genetics

ENU-Induced Mutations That Affect the Mouse Digestive Tract


Katherine L. Molnar-Kimber, Ph.D.
Department of Pathology
and Laboratory Medicine

Oncolytic Therapy of Colorectal Carcinoma by Replication Selective Adenoviruses


Eric J. Russell, M.D.
Department of Medicine
Hematology-Oncology Division

Post-Transcriptional Regulation of Prothrombin Gene Expression


Charmaine Stewart, M.D.
Department of Medicine
Gastroenterology Division

Determination of High Risk Behavior Among Intravenous Drug Users that Increase Risk of Chronic Hepatitis C Viral (HCV) Infection


Eric Weinberg, Ph.D.
Department of Biology

Formation of the Liver in the Zebrafish Embryo

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1999 Awards

Gregory H. Enders, M.D., Ph.D.
Department of Medicine
Division of Gastroenterology

Regulation and Role of the Tumor Suppressor p16INK4a in Intestinal Neoplasia


Jonathan A. Epstein, M.D.
Department of Medicine
Cardiovascular Division

Establishing Molecular Hierarchies Regulating Enteric Ganglia Development


Arupa Ganguly, Ph.D.
Department of Genetics

Role of DNA Mismatch Repair Genes in Families with Breast, Ovarian and Colon Cancer


David L. Gasser, Ph.D.
Department of Genetics

ENU-Induced Mutations That Affect the Mouse Digestive Tract


Linda Greenbaum, M.D.
Department of Medicine
Division of Gastroenterology

Function of C/EBPb in acute liver injury


Thomas A. Judge, M.D.
Department of Medicine
Division of Gastroenterology

Effect of blockade of B7-mediated t cell costimulation on IL-12 signaling


Katherine L. Molnar-Kimber, Ph.D.
Department of Pathology
and Laboratory Medicine

Oncolytic Therapy of Colorectal Carcinoma by Replication Selective Adenoviruses


Debra G. Silberg, M.D., Ph.D.
Department of Medicine
Division of Gastroenterology

The effect of Cdx1 and Cdx2 on gastric epithelium cells differentiation and gene expression

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1998 Awards

Simon Carding, Ph.D.
(Department of Clinical Studies
School of Veterinary Medicine)
Currently, University of Leeds

An in vitro model system for investigating intestinal epithelial cell: intraepithelial lymphocyte interactions


Linda Greenbaum, M.D.
Department of Medicine
Division of Gastroenterology

Cytokine activation in peroxisome proliferator-induced liver growth


Thomas Judge, M.D.
Department of Medicine
Division of Gastroenterology

Effect of blockade of B7-mediated T cell costimulation on IL-12 signaling


Kim M. Olthoff, M.D.
Department of Surgery

Early gene expression following liver transplanation


Michael A. Pack, M.D.
Department of Medicine
Division of Gastroenterology

Fine resolution mapping and molecular cloning of genes which regulate enterocyte development in the zebrafish


Elizabeth B. Rand, M.D.
Division of Gastroenterology and Nutrition
Children's Hospital of Philadelphia

Jagged1 expression studies


Debra G. Silberg, M.D., Ph.D.
Department of Medicine
Division of Gastroenterology

The effect of Cdx1 and Cdx2 on gastric epithelium cells differentiation and gene expression


Wenchao Song, Ph.D.
Center for Experimental Therapeutics
and Department of Pharmacology

Regulation of complement activation and inflammation by decay-accleration factor in the intestinal tract

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1998 Nutrition and Food Safety Awards

Barbara Haber, M.D.
Division of Gastroenterology and Nutrition
Children's Hospital of Philadelphia

Nutrition and outcome in pediatric chronic liver disease


Nita Salzman, Ph.D.
Department of Microbiology

The role of human enteric defensins and muscosal immunity


Gregory Schears, M.D.
Division of Anesthesiology and Critical Care
Children's Hospital of Philadelphia

Resting energy expenditure in intubated children

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1997 Awards

Clifford S. Deutschman, M.D.
Department of Anesthesia

Liver-restricted transcription factors in SIRS


Klaus H. Kaestner, Ph.D.
Department of Genetics

Intestinal Development in Cdx2 Mutant Mice


Daniel S. Kessler, Ph.D.
Department of Cell and Developmental Biology

Embryonic Development of the Vertebrate Digestive Tract


Kim M. Olthoff, M.D.
Department of Surgery

Early Gene Expression Following Liver Transplanation


Michael A. Pack, M.D.
Department of Medicine
Division of Gastroenterology

Fine Resolution Mapping and Molecular Cloning of Genes which Regulate Enterocyte Development in the Zebrafish


Elizabeth B. Rand, M.D.
Division of Gastroenterology and Nutrition
Children's Hospital of Philadelphia

Gene cloning within the Alagille region

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