Our laboratory studies the development of both the pulmonary and cardiovascular systems with a focus on the molecular pathways driving normal development and how these pathways are disrupted in disease. We utilize multiple approaches and model systems to investigate the role of important transcription and signaling pathways in lung and cardiovascular development with a current focus on members of the GATA and Fox transcription factor families and Wnt signaling. The overall goal of our research is to apply state of the art genetic, biochemical, and systems biology approaches to increase our understanding of lung and cardiovascular disease in humans.