The Morrisey Lab is interested in cell fate decisions in the lung that are governed by signaling and transcriptional mechanisms during development, tissue homeostasis, and regeneration. We utilize multiple model systems in our work including novel transgenic mouse models, advanced imaging techniques, and incorporate custom bioinformatics platforms to interrogate NGS datasets to enhance our wet lab bench research.
Our lab is composed of a highly collaborative and collegiate team of graduate students, undergraduate students, postdoctoral fellows and physician scientists. In addition to trainees, the Morrisey lab is supported by a group of highly skilled research technicians, staff scientists, and a bioinformatics team to enhance the research enterprise and provide administrative support to accelerate research discoveries and innovation. We encourage you to explore our personnel page as many former students and postdocs from our lab are emerging as the next generation of leaders in pulmonary and cardiovascular research and medicine.
Penn Center for Pulmonary Biology
Lung diseases, both congenital and those acquired throughout life, continue to be among the top causes of mortality and morbidity in the US and the number of people affected by these diseases continues to grow each year. The Penn Center for Pulmonary Biology (PCPB) was formed to fulfill the growing demand for enhanced early detection capabilities and the development of more efficacious treatment options for both adult and pediatric lung diseases. The PCPB is led by Dr. Edward E. Morrisey, and unites the resources, faculty and innovation of the Hospital of the University of Pennsylvania, the Department of Medicine at UPenn and the Children’s Hospital of Philadelphia to apply basic developmental research findings to inspire new state of the art approaches for increasing our understanding and treating patients affected by lung diseases. The PCPB is housed in a completely renovated, state of the art research space in Stemmler Hall with more than 13,000 square feet of newly designed open concept laboratory workspaces, offices and support areas. In addition to the research lab space, the PCPB also provides access to high quality human lung tissue and genomic analysis of existing and newly generated large scale sequencing data sets of human and mouse models of lung diseases. For more information please visit the PCPB website
Recent Lab News
Congratulations to Dr. Will Zacharias! He has accepted a Full-Time Faculty position at Pediatrics and Medicine in the Division of Pulmonary Biology at Cincinnati Children's Hospital and Division of Pulmonary, Allergy, and Critical Care Medicine at the University of Cincinnati College of Medicine.
Congratulations to Ian Penkala! He was awarded on F31 fellowship from NHLBI.
Congratulations to Dr. Collin Stabler! He presented his start-up LungDurance in front of the BioAdvance CEO as part of Penn i-Corps program. The press article is in the link
In our recent study, we examine the cellular heterogeneity in the lung mesenchyme. Using a combination of lineage tracing, population-based and single-cell RNA sequencing, we identify spatially and transcriptionally distinct myofibrogenic and alveolar niche cell types. Importantly, these mesenchymal subtypes exhibit unique abilities to proliferate after injury and to provide ligands such as Fgf/IL-6/Bmp that promote alveolar epithelial cell growth.