Stephen J. Moss Laboratory
Selected Publications
Tretter, V., Jacob, T.C., Mukherjee, J., Fritschy, J-M., Pangalos, M. and Moss S.J. (2008). The clustering of GABAA receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor α2 subunits to gephyrin. J. Neurosci (in press).
Kittler, JT, Chen,G., Kukhtina, V., Vahedi-Faridi, A., Tretter, V., Smith, K., Kristina McAinsh, K., Arancibia-Carcamo, L., Saenger, W., Haucke, V. Yan Z., and Moss, S.J. (2008). A tyrosine motif in the GABAΑR gamma2 subunit regulates phosphorylation-dependent binding to the clathrin adaptor protein 2 (AP2) to control surface receptor number and inhibitory synaptic transmission. PNAS (in press).
Terunuma, M., Xu, J., Zhu, Y., Vithlani, M., Kuramoto N., Kittler, J.T., Haydon, P.G., D. A. Coulter, D.A., and Moss S.J. (2008). Modified GABAA receptor phospho-dependent membrane trafficking underlies compromised synaptic inhibition during status epilepticus. J. Neurosci 28(2): 376-84 .
Pathak, H., Weissenger, F., Terunuma, M., Carlson, G., Hsu, F-C., Moss, S.J. and Coulter, D. (2007) Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J. Neurosci 27:14012-22.
Saliba, R.S., Michels, G., Jacob, T.C., Pangalos, M.N. and Moss, S.J. (2007) Activity-dependent ubiquitination of GABAA receptors regulates their accumulation at synaptic sites. J. Neurosci. 48 13341-13351.
Lee, H.H., Walker, J.A., Williams, J.R., Goodier, R.R., Payne, J.A. and Moss, S.J. (2007). Direct PKC-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter, KCC2. J. Biol. Chem. 282 29777-84.
Houston, C.M., Lee, H.H., Hosie, A.M., Moss, S.J. and Smart, T.G. (2007). Identification of the sites for CaMK-II dependent phosphorylation of GABAΑ receptors. J. Biol. Chem. [Epub].
Michels, G. and Moss, S.J. (2007). GABAA Receptors: Properties and Trafficking. Crit. Rev. Biochem. Mol. Biol. 42(1)3-14.
D'Ascenzo, M., Fellin, T., Terunuma, M., Revilla-Sanchez, R., Meaney, D.F., Auberson, Y.P., Moss, S.J. and Haydon, P.G. (2007). mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc. Natl. Acad. Sci. USA 104(6):1995-2000.
Kanematsu, T., Fujii, M., Mizokami, A., Kittler, J.T., Nabekura, J., Moss, S.J. and Hirata, M. (2007). Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABA(A) receptors mediated by clathrin and AP2 adaptor complex. J. Neurochem. 101(4): 898-905.
Kuramoto, N., Wilkins, M.E., Fairfax, B.P., Revilla-Sanchez, R., Terunuma, M., Tamaki, K., Iemata, M., Warren, N., Couve, A., Calver, A., Horvath, Z., Freeman, K., Carling, D., Huang, L., Gonzales, C., Cooper, E., Smart, T.G., Pangalos, M.N. and Moss, S.J. (2007). Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron 53(2):233-47.
Arancibia-Carcamo, I.L. and Moss, S.J. (2006). Molecular organization and assembly of the central inhibitory postsynapse. Results Probl. Cell. Differ. 43:25-47.
Bogdanov, Y., Michels, G., Armstrong-Gold, C., Haydon, P.G., Lindstrom, J., Pangalos, M. and Moss, S.J. (2006). Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. The EMBO Journal 25(118):4381-9.
Chen, G., Kittler, J.T., Moss, S.J., and Yan, Z. (2006). Dopamine D3 receptors regulate GABAΑ receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J. Neurosci. 26(9):2513-21.
Jacob, T.C., Bogdanov, Y., Magnus, C., Saliba, R.S., Kittler, J.T., Haydon P.G. and Moss S.J. (2005). Gephyrin modulates the cell surface dynamics of synaptic GABAΑ receptors J. Neurosci. 25(45):10469-78.
Kittler, J.T, Chen, ,G., Honing, S., Bogdanov, Y., McAinsh, K., Arancibia-Carcamo, I.L., Jovanovic, J.N., Pangalos, M.N., Haucke, V., Yan, Z. and Moss, S.J. (2005). Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAΑ receptors regulates the efficacy of inhibitory synaptic transmission. Proc. Natl. Acad. Sci. USA 102 14871-6.
Couve, A., Calver, A.R., Fairfax, B., Moss, S.J. and Pangalos M.N. (2004). Unravelling the unusual signalling properties of the GABAB receptor. Biochem. Pharmacol. 68 1527-36.
Kittler, J.T., Thomas, P., Tretter, V., Bogdanov, Y., Haucke, V., Smart, T.G. and Moss S.J. (2004). Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc. Natl. Acad. Sci. USA 101: 12736-41.
Jovanovic, J.N., Thomas, P., Kittler, J.T., Smart, T.G. and Moss S.J. (2004). Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABAΑ receptor phosphorylation, activity, and cell-surface stability. J. Neurosci. 24 522-30.
Fairfax, B.P., Pitcher, J.A., Scott, M.G., Calver, A.R., Pangalos, M.N., Moss, S.J. and Couve, A. (2004). Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. J. Biol. Chem. 279: 12565-73.
Brandon, N.J., Jovanovic, J., Smart, T.G. and Moss, S.J. (2002). Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABAΑ receptors with the activation of G-protein-coupled receptors. J. Neurosci. 22 6353-61.
Couve, A., Thomas, P., Hirst, W., Calver, A.R., Pangalos, M.N. Walsh, F.S., Smart, T.G. and Moss, S.J. (2002). Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling. Nat. Neurosci. 5: 415-24.
Bedford, F.K., Kittler, J.T., Muller, E., Thomas, P., Uren, J.M., Merlo, D., Wisden, W., Triller, A., Smart, T.G. and Moss S.J. (2001). GABAΑ receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat. Neurosci. 4: 908-16.
Moss, S.J. and Smart, T.G. (2001). Constructing inhibitory synapses. Nat. Rev. Neurosci. 2: 240-50.
Filippov, A.K., Couve, A., Pangalos, M.N., Walsh, F.S., Brown, D.A. and Moss, S.J. (2000). Heteromeric assembly of GABAB R1 and R2 receptor subunits inhibits Ca2+ current in sympathetic neurons. J. Neurosci. 20: 2867-74.
Kittler, J.T., Delmas P., Jovanovic, J.N., Brown, D.A., Smart, T.G. and Moss S.J. (2000). Constitutive endocytosis of GABAΑ receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J. Neurosci. 20: 7972-7.
Brandon, N.J., Uren, J.M., Kittler, J.T., Wang, H., Olsen, R., Parker, P.J. and Moss, S.J. (1999). Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. J. Neurosci. 19: 9228-34.
Wang, H.W., Bedford, F.K., Brandon, N.J., Moss, S.J. and Olsen R.W. (1999). GABAΑ-receptor-associated protein link GABAΑ receptors and the cytoskeleton. Nature 397: 69-72.
Hanley, J.G., Koulen, P., Bedford, F.K, Gordon-Weeks, P.R. and Moss, S.J. (1999) The protein MAP-1B links GABAC receptors to the cytoskeleton at retinal synapses. Nature 397: 66-9.
Gorrie, G.H., Vallis, Y., Stephenson, A., Whitfield, J., Browning, B., Smart, T.G. and Moss, S.J. (1997). Assembly of GABAΑ receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts. J. Neurosci. 17: 6587-96.
Moss, S.J., Gorrie, G.H., Amato, A. and Smart T.G. (1995). Modulation of GABAΑ receptors by tyrosine phosphorylation. Nature 377: 344-8.
Moss, S.J., Smart, T.G., Blackstone, C.D. and Huganir R.L. (1992). Functional modulation of GABAΑ receptors by cAMP-dependent protein phosphorylation. Science 257: 661-5.
Last Updated: 31-Jan-2008