The main objective of this program is to improve the quality of clinical research training by providing didactic courses in the fundamental skills needed for translational research. Through the further development of a graduate program in translational Research (MTR) that will provide in depth instruction in the fundamental skills, methodology, and principles necessary for the well trained independent clinical investigator we hope to provide an internal framework for PENN faculty and MDs enrolled in a fellowship program at Penn which will enable them to pursue a career in translational research.