Murray Lab

The Laboratory of John Murray

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A heatmap showing how many genes (of 100 tested) were expressed differently between each pair of cells in the C. elegans lineage

How do regulatory factors combine to control animal development? How does context influence which targets are regulated by a transcription factors? How are these decisions encoded in the genome sequence? The Murray laboratory uses live-cell imaging, genetics, genomics and computational tools to answer these questions. We use the nematode Caenorhabditis elegans because of its ease of manipulation, its invariant development and the powerful experimental tools available for its study.

 

Download a model of wild-type development