Rapid Anticonvulsant Medication Prior to Arrival Trial
PI: Robert Silbergleit, MD - University of Michigan
Status: RAMPART enrollment is complete and the results are posted. Read more
What is RAMPART?
Seizures are a common medical problem. Most seizures are short and stop by themselves, but those that donít stop in seconds or minutes are a dangerous life-threatening medical emergency. These prolonged seizures, also called status epilepticus, occur when there is a sudden and long disruption of the brainís normal electrical activity. They can often cause unconsciousness, and jerking and twitching movements.
Paramedics often have medications that can stop these seizures, but the best way to give them is not known. RAMPART is a research study to figure out whether giving anti-seizure medicine works better and more quickly when given through an IV (a small tube in the vein) or when given as a shot in the muscle. Two similar medicines - midazolam and lorazepam - will be used. Both are already used by paramedics in the field and by doctors in the hospital to stop seizures. Lorazepam is commonly given IV, and midazolam is commonly given as a shot in the muscle.
Why are we doing this study?
The purpose of this study is to find out which type of routine care is the best way for paramedics to stop someone from seizing.
What makes RAMPART different from other research studies?
Unlike most research studies, the individual participating in RAMPART will not be able to provide permission or consent before treatment is given because he/she is having a seizure and is unconscious. Therefore, RAMPART will be conducted under federal rules that allow a waiver or exception from informed consent for emergency research (EFIC) studies. Click here for more information regarding these special rules.