•The glial scar contains extracellular
matrix molecules including chondroitin sulphate proteoglycans (CSPGs), which
inhibit axon growth in
vitro. Regenerating axons
stop at CSPG-rich regions in
•Chondroitinase ABC (ChABC) inactivates CSPG
by removing glycosaminoglycan (GAG) chains.
• Intrathecal delivery of ChABC in rats that
received a dorsal overhemisection degraded CS-GAG at the injury site,
upregulated GAP-43 in DRG cells and enhanced regeneration of ascending sensory
and descending corticospinal tract axons.
•ChABC treatment also restored post-synaptic
responses below the lesion after electrical stimulation of corticospinal
neurons, and enhanced recovery of locomotor and proprioceptive functions.
Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN,
Fawcett JW, McMahon SB. Chondroitinase ABC promotes functional recovery after
spinal cord injury. Nature