Chondroitinase-ABC Promotes Regeneration and Functional Recovery after Spinal Cord Injury

Bradbury et al., Nature 416:636-40,2002

Anti-PKC-g labels CST axons

CST axons degenerate below a dorsal column lesion

BDA anterograde labeling of CST in control cervical cord

Labeling disappears permanently below a dorsal column lesion in vehicle-infused cord

Anterogradely labeled fibers return in ChABC-infused cord

Near lesion, axons sprout and invade gray matter

White matter

Grey matter

Dorsal column lesion