Course SummaryDysfunction of the human brain can produce a wide variety of neurological and psychiatric illnesses. Over the past decades, neuroscientists have begun to unravel the basic underlying mechanisms of a number of important diseases of the nervous system, at the cellular, molecular and genetic levels. None of these disorders are completely understood, and, perhaps more importantly, none are yet susceptible to either total prevention or cure, so these conditions remain among the most important health problems of our society. This course is designed to familiarize neuroscientists with basic information about a number of important neurological and psychiatric diseases, focusing on a relatively brief clinical description of the condition and a more in depth discussion of what is currently understood about the basic pathobiology of the disorder.
The course was divided into two parts: formal didactic teaching sessions (taking place on Tuesdays) and research seminars/ chalk talks (taking place on Thursdays). The didactic lectures began with the clinical presentation of the disease/disorder in question (~15"), then discussed the current hypotheses about the mechanisms underlying the disease (~45") and finished with current treatments (~10").
During the Thursday afternoon sessions, Penn faculty members presented research seminars or chalk talks describing the research she or he was conducting in the particular disease. Papers from the current literature were provided to students in advance of the seminar so that students could familiarize themselves with the research. It was expected that this format, of having a research seminar given after the introductory lecture, would allow students to become familiar in depth with at least one approach to each disease. The research seminars are not presented on this website.
There is no one text suitable for the course; as noted above, readings from the current literature were assigned for each class. However, many of the chapters in "The Molecular and Genetic Basis of Neurological Disease" edited by Roger Rosenberg, Stanley Pruisiner, Salvatore DiMauro, and Robert Barchi, Edition 2 or 3, are a good initial source.
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Lectures from NBD Overview Course - Spring 2006
|Mechanisms of brain dysfunction||Marc A. Dichter, MD, PhD||Jan 10, 2006|
|Stroke and ischemic brain damage||Marc A. Dichter, MD, PhD||Jan 17, 2006||not available|
|Axonal injury and repair in the CNS and PNS||Michael E. Selzer, MD, PhD||Jan 24, 2006|
|Epilepsy - seizure mechanisms||Marc A. Dichter, MD, PhD||Jan 31, 2006|
|Mechanisms of epileptogenesis||Marc A. Dichter, MD, PhD||Feb 2, 2006|
|Alzheimer's disease||Marc A. Dichter, MD, PhD||Feb 7, 2006|
|Parkinson's disease||David R. Lynch, MD, PhD||Feb 14, 2006|
|Huntington's and other triplet repeat diseases||David R. Lynch, MD, PhD||Feb 21, 2006||not available||not available|
|Depression and affective disorders||Wade Berrettini, MD, PhD||Feb 28, 2006|| video
|Amyotrophic lateral sclerosis||Marc A. Dichter, MD, PhD||Mar 7, 2006|
|Neurobiology of macular degeneration||Joshua Dunaief, MD, PhD||Mar 14, 2006|
|Schizophrenia||Raquel Gur, MD, PhD||Mar 21, 2006|
|Multiple sclerosis||Clyde Markowitz, MD||Mar 28, 2006|
|Addiction||Charles P. O'Brien, MD, PhD||Apr 4, 2006|
|Effects of AIDS on the nervous system||Francisco Gonzalez-Scarano, MD||Apr 11, 2006|
|The neurobiology of autism||Edward S. Brodkin, MD||Apr 18, 2006|
|Disorders of brain development||Peter B. Crino, MD, PhD||Apr 25, 2006|