Many
single gene mutations in both mice and humans produce epilepsy syndromes
•Many forms of
absence epilepsy
•mostly
abnormal Ca channels
•Na channels
•GABAA receptors
•Some partial
epilepsies
•Same phenotype can be
produced by multiple gene abnormalities
•One gene may
produce several phenotypes
•Some
syndromes are age-related
•Other genes
may affect expression of the epilepsy gene