AD, PD and ALS
T/R 8:30-10:00; 1st half of Spring 2009
Course Summary
TEXTBOOK: None. All readings will be assigned from the primary literature. Sometimes videos will be assigned in lieu of readings.SYLLABUS: Click here.
COURSE WIKI: This course made use of a wiki (www.pbwiki.com) for distributing updated versions of the syllabus and for collecting student blogs and questions for discussion. We highly recommend using a tool like this. PB wiki comes in free and paid versions, depending on your needs.
Viewing the Lectures from 2009
From a PC: Just click on the linkFrom a Mac: download - just once - a copy of silverlight.
Lectures - Spring 2009
Lecture Title | Lecturer | Date | Video/Slide Presentation |
---|---|---|---|
Clinical presentation of AD; diagnostic criteria; AD biomarkers: biochemical and imaging | Steven Arnold, MD | Jan 15 | Video/Slides |
AD Genetics | Jerry Schellenberg, PhD | Jan 20 | Video/Slides |
Protein misfolding as a common mechanism among many neurodegenerative disorders; Overview of clinical trials in AD (inclu. which pathophysiological mechanisms were targeted) | Virginia M.Y. Lee, PhD | Jan 22 | Video/Slides |
Mechanisms of AD pathogenesis and pathophysiology, e.g. amyloid cascade hypothesis, tau, and the therapeutic approaches they suggest. Review of recently completed clinical trials and of the NSAID (non-steroidal anti-inflammatory) trial. | Virginia M.Y. Lee, PhD | Jan 27 | Video/Slides |
Tau: involvement in AD and FTD (fronto-temporal dementia). Potential tau and tau-related (e.g. MT stabilizing, kinase inhibiting) therapeutics. | John Trojanowski MD, PhD | Jan 29 | Video/Slides |
Glutamate toxicity and the role of glutamate transporters. Examples of glutamate modulators as therapeutic agents | Mike Robinson, PhD | Feb 3 | Video/Slides |
Parkinson's Disease: Clinical overview and review of clinical trials | Nabila Dahodwala, MD | Feb 5 | Video/Slides |
Parkinson's Disease: genetics - alpha synuclein, parkin, DJ1, PINK1, and LRRK2. Gauchier's mutations. Gene therapy for PD. | Vivianna Van Deerlin, MD, PhD | Feb 10 | Video/Slides |
Parkinson's Disease: pathological mechanisms; review of mechanisms upon which clinical trials and medications have been based: e.g. antioxidants (monoamine oxidase B inhibitor, Co Q10 etc); dopamine agonists, Catechol-O-methyl transferase (COMT) inhibitors, NMDA receptor antagonists | Benoit Giasson, PhD | Feb 12 | Video/Slides |
Oxidative stress: Role across various neurodegenerative disorders and role as potential therapeutic agents. | Harry Ischiropolous, PhD | Feb 17 | Video/Slides |
Clinical overview of FTD and ALS | Murray Grossman, MD | Feb 19 | Video/Slides |
TPD43: a newly identified pathological protein in sporadic ALS. Pathology, pathological mechanisms, genetics; imagining a "bench to bedside" story | Virginia M.Y. Lee, PhD | Feb 24 | Video/Slides |
Student Presentations | - | Feb 26 | |
Student Presentations | - | Mar 3 | |
Student Presentations | - | Mar 5 |