Neuroscience Graduate Group Journal Club Papers

Journal Club meets at 12:30-2:00pm on Tuesdays in Barchi Library
Co-directors: D. Kacy Cullen, Ph.D (dkacy@mail.med.upenn.edu) and Heath D. Schmidt, Ph.D. (hschmidt@mail.med.upenn.edu)

Course Description and Details

Note: Each presentation on Tuesday will be on the research papers related to thats week's MINS Seminar on Wednesday.

 

January 28, 2015
Dr. Ben Barres, Stanford University
Senescent synapses:  An idea for why aging brains don’t work so well and are so vulnerable to neurodegenerative disease
Mentor:
Erika Holzbaur
Presenter #1: Christina Wright
Preseneter #2: Emily Fernandez
Attending Lunch:Christina Wright, Barbara Terzic, Nicole Hernandez, Emily Fernandez,Yeri Song,Carolyn Keating, Felicia Davatolhagh

A Dramatic Increase of C1q Protein in the CNS during Normal Aging 

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

The Complement System An Unexpected Role in Synaptic Pruning During Development and Disease                           

February 4, 2015
Dr. Jeffrey Rothstein,
Johns Hopkins Medicine
C9orf72 and RNA toxicity as the major cause of ALS/FTD: Its all about how to manage traffic!"
Mentor:
Erika Holzbaur
Presenter #1: Barbara Terzic
Presenter #2: Sheng Tang
Attending Lunch: Barbara Terzic, Carolyn Keating,Yeri Song, Sarah Reitz, Emily Fernandez, Graham Baum

Oligodendroglia metabolically support axons and contribute to neurodegeneration

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

 

February 11, 2015
Dr. Elyse Schauwecker,
USC
Genetic architecture of natural variation in susceptibility to seizure-induced excitotoxic cell death
Mentor:
Joe Zhou
Presenter #1: Nicole Hernandez
Presenter #2: Barbara Terzic
Attending Lunch: Nicole Hernandez, Emily Fernandez,Christina Wright, Felicia Davatolhagh, Barbara Terzic 

Susceptibility to Seizure-Induced Excitotoxic Cell Death Is Regulated by an Epistatic Interaction between Chr 18 (Sicd1) and Chr 15 (Sicd2) Loci in Mice

Galanin Receptor 1 Deletion Exacerbates Hippocampal Neuronal Loss after Systemic Kainate Administration in Mice

The relevance of individual genetic background and its role in animal models of epilepsy

 

February 18, 2015
Dr. Serena Dudek, NIH
Love me or hate me but forget me not:  effects of social neuropeptides on hippocampal CA2 synapses
Mentor:
Ted Abel
Presenter #1: Felicia Davatolhagh
Presenter #2: Yeri Song
Attending Lunch: Emily Fernandez, Felicia Davatolhagh, Marissa Kamarck, Nicole Hernandez, Nicole Bowman, Analise Gruenewald, Barbara Terzic

Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2

Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2

February 25, 2015
Dr. Naoshige Uchida,
Harvard University
“Dissecting computations in dopamine reward circuit”
Mentor:
Joel Mainland
Presenter #1: Hannah Shoenhard
Presenter #2: Sarah Reitz
Attending Lunch: Sarah Reitz, Nicole Hernandez, Analise Gruenewald, Hannah Shoenhard,
Nicole Bowman

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

 

March 4, 2015
Dr. Daniel Colon-Ramos, Yale University
“Glycolytic enzymes dynamically localize to neuronal synapses to meet local energy demands”
Mentor:
Chris Fang-Yen
Presenter #1: Carolyn Keating
Presenter #2:
Marissa Kamarck
Attending Lunch: Nicole Hernandez, Marissa Kamarck, Sneha Narasimhan, Emily Fernandez, Felicia Davatolhagh

Serotonergic neurosecretory synapse targeting is controlled by Netrin-releasing guidepost neurons in C. elegans

Synapse location during growth depends on glia location

The actin cytoskeleton in presynaptic assembly

 

March 11, 2015
Dr. Hongjun Song, Johns Hopkins Medicine
Dynamic DNA methylation regulates neuronal flexibility
Mentor:
Joe Zhou
Presenter #1: Felicia Davatolhagh                                                           
Presenter #2:
Christina Wright
Attending Lunch: Christina Wright, Sneha Narasimhan, Hannah Shoenhard, Nicole Bowman, Marissa Kamarck, Barbara Terzic

Neuronal activity modifies the DNA methylation landscape in the adult brain

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

 

March 25, 2015
Dr. Kay Tye, MIT
Neural circuits important for valence processing
Mentor:
Isabel Muzzio
Presenter #1: Christina Wright
Presenter #2:
Sneha Narasimhan
*Note: Presentations will be held in class on March 17th.
Attending Lunch: Sarah Reitz, Sneha Narasimhan, Christina Wright, Felicia Davatolhagh, Hannah Shoenhard, Marissa Kamarck, Barbara Terzic

From circuits to behaviour in the amygdala

BLA to vHPC Inputs Modulate Anxiety-Related Behaviors

Decoding Neural Circuits that Control Compulsive Sucrose Seeking

 

March 27, 2015 (Please note: This meeting will be held on a Friday)
Dr. Christof Koch, Allen Institute for Brain Research
The unsolved problem of Consciousness
Mentor:
Student Host
Presenter #1:Katerina Placek
Presenter #2: Nicole Bowman
*Note: Presentations will be held in class March 24th.
Attending Lunch: Carolyn Keating, Felicia Davatolhagh, Sarah Reitz, Marissa Kamarck,Graham Baum, Nicole Bowman, Katerina Placek, Marissa Kamarck, Barbara Terzic, Yeri Song

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Single-Cell Responses to Face Adaptation in the Human Medial Temporal Lobe

Consciousness: Here, There but Not Everywhere

 

April 8, 2015
Dr. Carol Mason, Columbia University
The path from eye to brain: Genes encoding neurogenesis and axon wiring in the binocular circuit
Mentor:
Ted Abel
Presenter #1: Emily Fernandez
Presenter #2:
Hannah Shoenhard
Attending Lunch: Christina Wright, Marissa Kamarck, Nicole Hernandez, Hannah Shoenhard,Nicole Bowman

Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice

Optic Chiasm Presentation of Semaphorin6D in the Context of Plexin-A1 and Nr-CAM Promotes Retinal Axon Midline Crossing

The Development of Retinal Decussations

 

April 15, 2015
Dr. David Julius, UCSF
“TRP channels of the pain pathway: connecting physiology to atomic structure
Mentor:
Maja Bucan
Presenter #1: Marissa Kamarck
Presenter #2:
Analise Gruenewald
Attending Lunch: Graham Baum, Nicole Bowman, Nicole Hernandez, Felicia Davatolhagh, Hannah Shoenhard, Katerina Placek, Marissa Kamarck, Barbara Terzic

TRP Channels and Pain

Molecular basis of infrared detection by snakes

TRPV1 structures in distinct conformations reveal activation mechanisms

 

April 22, 2015
Dr. Lori Zeltser, Columbia University
Developmental influences on circuits regulating food intake
Mentor:
Student Host
Presenter #1: Sneha Narasimhan
Presenter #2:
Emily Fernandez
Attending Lunch:Christina Wright, Sneha Narasimhan, Nicole Hernandez, Marissa Kamarck, Yeri Song, Nicole Bowman

Developmental Switch of Leptin Signaling in Arcuate Nucleus Neurons

Functional Organization of Neuronal and Humoral Signals Regulating Feeding Behavior

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

April 29, 2015
Dr. Fan Wang, Duke University
"Neural circuits underlying sensorimotor behaviors"
Mentor:
Wenqin Luo
Presenter #1: Graham Baum
Presenter #2:
Sarah Reitz
Attending Lunch:
Nicole Bowman, Marissa Kamarck, Analise Gruenewald

The Organization of Submodality-Specific Touch Afferent Inputs in the Vibrissa Column

New Modules Are Added to Vibrissal Premotor Circuitry with the Emergence of Exploratory Whisking

How the brainstem controls orofacial behaviors comprised of rhythmic actions

May 6, 2015
Feng Zhang
, MIT
"Genome Editing Using CRISPR-Cas9 "
Mentor:
Joe Zhou
Presenter #1: Sheng Tang
Presenter #2:
Nicole Hernandez
Attending Lunch:
Nicole Hernandez, Nicole Bowman, Graham Baum, Sneha Narasimhan, Marissa Kamarck, Sheng Tang, Barbara Terzic

Development and Applications of CRISPR-Cas9 for Genome Engineering

In vivo genome editing using Staphylococcus aureus Cas9

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

May 13, 2015 - TBD, Prof. Sejnowski will be rescheduled for a future date
Terence Sejnowski,
Salk Institute
" "
Mentor:
Presenter #1:
Analise Gruenewald
Presenter #2:
Katerina Placek
Attending Lunch:
Katerina Placek, Marissa Kamarck, Analise Gruenewald, Nicole Bowman