Mechanisms of Neuronal Injury and Neuroprotection - INSC 600-002

T/R 10:30-noon; 1st half of Spring 2009

Module Overview

A bench-to-bedside presentation of the molecular mechanisms of acute nervous system injury, therapeutic strategies for intervention, and clinical applications of neuroprotection.

Module Goals

Most sessions will discuss: a) mechanisms of injury; b) targets for therapy and past clinical trials; c) development of future treatments via new clinical trials.

Assigned Readings

Papers from the primary literature will be assigned weekly and be presented by teams of students during the Friday course sessions. There will be no lecture on these days. Students will read the background readings and generate questions to be used during the in-class discussion. <

Viewing the Lectures from 2009

From a PC: Just click on the link
From a Mac: download - just once - a copy of silverlight.

Lectures - Spring 2009

Topic	Speaker	Date	Video/Slide Presentation
Introduction	Neumar	Jan 15	Video/Slides
Cell death pathways	Siman	Jan 20	Video/Slides
Ca-activated Proteases	Neumar	Jan 27	Video/Slides
Oxidative Stress	Ischiropolous	Feb 3	Video/Slides
Excitotoxicity	Robinson	Feb 10	Video/Slides
Inflammation	Kariko	Feb 17	Video/Slides
Endogenous protection	Welsh	Feb 24	Video/Slides
Pharmacological Protection	Greenberg	Mar 3	Video/Slides

Viewing the Lectures from 2007

You will need RealPlayer to view the videos. Make sure to click "Free Download."

Lectures - Spring 2007

Date Subject-Lecturer	Real video	Slides only
10-Jan: Overview-Neumar/Welsh		slides 9,10,11 intentionally blank
17-Jan: Excitotoxicity-Robinson
24-Jan: Cell death pathways-Siman
31-Jan: Oxidative stress-Ischiropolous
7-Feb: Role of Calpains in Acute Brain Injury-Neumar
14-Feb: SNOW DAY!
16-Feb: Inflammation-Kariko
21-Feb: Preconditioning-Welsh

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