TEXTBOOK: Please check the electronic blackboard for readings: readings often will be assigned for the various topics. There is no one text suitable for the course. Many of the chapters in "The Molecular and Genetic Basis of Neurological Disease" edited by Roger Rosenberg, Stanley Pruisiner, Salvatore DiMauro, and Robert Barchi, Edition 2 or 3, are a good initial source. Copies are available on reserve in the medical library and in the Neuroscience library.
TYPES OF ACTIVITIES FOR WHICH STUDENTS WILL PREPARE IN ADVANCE OF CLASS: For the following types of student-led activities the class will be divided into two teams. The teams will stay the same throughout the semester. For each activity, two (or perhaps more) members of each team will sign up to take primary responsibility for their team's presentation. The other members of each team will be responsible for assisting their team members and for answering questions during the discussion.
Clinical Trials Presentations: Students will read a paper(s) describing the results of a clinical trial(s) for a given disease. After the designated students from each team present their trial, other team members will compare and contrast their team's trial with that of the other team.
Debates on alternative mechanisms: Students will read papers giving evidence in support of a particular mechanism as central to the etiology of a given disorder. The two designated students from each team will present the best evidence in support of "their" mechanism. After the initial arguments are made, students may debate the points presented by the opposing team.
Presentations of various hypotheses: These will be similar to the "debates" but students will not be responsible for contrasting "their" hypothesis or mechanism with the others that are presented by the other students.
Website Review: Students will review a website (for a disease or a foundation) and write a 1 page, single-spaced summary about the site. Details on how the focus the review are included on the syllabus.
GRADING: Grades will be based on quality of presentations, written assignments, and ability to answer questions and participate in the discussions during class. At the end of the term, students will write a ~3 page 'mini grant proposal" on one of the diseases discussed in class. More information will be provided towards the end of the semester.
SYLLABUS: Just click HERE.
|Mechanisms of brain dysfunction||Marc A. Dichter, MD, PhD||Sept 11, 2007|
|How Cells Die||Robert W. Neumar, MD, PhD||Sept 11, 2007|
|Stroke||Marc A. Dichter, MD, PhD||Sept 18, 2007|
|Regulation of NMDA receptor function and excitoxicity||David R. Lynch, MD, PhD||Sept 20, 2007|
|Alzheimer's Disease||Marc A. Dichter, MD, PhD||Sept 25, 2007|
|Clinical Trials: Trials and Tools of the Trade
Please note that there are many more (useful) slides than were presented during the lecture
|Laura Balcer, MD, MSCE||Sept 27, 2007|
|ALS||Marc A. Dichter, MD, PhD||Oct 2, 2007|
|Clinical Trials Presentations (by students)
Stroke and ALS trials
|Oct 4, 2007|
|Huntington's Disease and other triplet repeat disorders||David R. Lynch, MD, PhD||Oct 9, 2007|
|Animal Models of Psychiatric Disorders and role of endophenotypes||Maya Bucan, PhD||Oct 11, 2007|
|Schizophrenia||Marc A. Dichter, MD, PhD||Oct 16, 2007|
|Using simple biological models for neurodegenerative disorders||Aaron Gitler, PhD||Oct 18, 2007|
|Parkinson's Disease||David R. Lynch, MD, PhD||Oct 23, 2007|
|Mitochondrial dysfunction in neurodegenerative disease||Robert Wilson, PhD||Oct 25, 2007|
|Epilespy-seizure mechanisms||Marc A. Dichter, MD, PhD||Oct 30, 2007|
|Mechanisms of epileptogenesis||Douglas Coulter, PhD||Nov 1, 2007|
|NO CLASS - Society for Neuroscience Meeting||Nov 6, 2007|
|Autism and other spectrum disorders||Edward (Ted) S. Brodkin, MD||Nov 8, 2007|
|Interactions between the Immune and Nervous systems||Katalin Kariko, PhD||Nov 13, 2007|
|Multiple Sclerosis||Marc A. Dichter, MD, PhD||Nov 15, 2007|
|Diseases of Peripheral Nerve||Steve S. Scherer, MD, PhD||Nov 20, 2007|
|NO CLASS - Thanksgiving||Nov 22, 2007|
|Disorders of Brain Development||Peter B. Crino, MD, PhD||Nov 27, 2007|
|Macular Degeneration||Joshua Dunaief||Dec 6, 2007|
|Class Discussion led by students: How do mutations in widely expressed proteins lead to degeneration or dysfunction of small subsets of neurons?||J. Paul Taylor, MD, PhD, Moderator||Dec 11, 2007|
|Depression and Affective Disorders||Marc Dichter, MD, PhD||Dec 13, 2007||Not avail||Not avail|