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Definitions come from the US Federal Food, Drug and Cosmetics Act (FDCA), the Dietary supplements Health and Education Act (DSHEA), the following FDA Centers: the Center for Drug Experimentation and Regulation (CDER) and the Center for Biologic Experimentation and Regulation (CBER), and the Center for Disease Control.

What is the Investigational Agent?
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Drug
Biologic
Allergenic
Blood or Blood Product
Gene Therapy Product
Somatic Cell Therapy
Vaccine
Dietary Supplement
Herb or Herbal Product
Cosmetic
None of these