Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Boerckel Lab

Welcome to Boerckel Lab

  • Boerckel Lab

My laboratory is interested in the mechanobiology of development and regeneration. We study how mechanical cues influence morphogenesis, growth, adaptation, and repair, and how these physical cues can be used to engineer functional tissues. We are currently focused on the molecular mechanisms that control cellular mechanosensation during bone and blood vessel development and on creation of tissue engineering strategies that recapitulate these developmental mechanisms for tissue regeneration. Current projects in the lab aim to understand the roles of the transcriptional co-activators YAP and TAZ in regulating cytoskeletal dynamics and cell motility, vasculogenesis, and bone development and repair, as well as engineering vascularized tissues by reverse-engineering the process of development.